Does more intense competition lead to higher growth?

The relationship between the intensity of competition in an economy and its long-run growth is an open question in economics. Theoretically, there is no clear-cut answer. Empirical evidence exists, however, that in some sectors more competition leads to more innovation, and accelerates productivity growth. To complement those findings, and capture economy-wide effects, the authors conduct a cross-country study. They examine the impact on growth of various measures having to do with intensity of domestic competition - beyond the effects of trade liberalization. Their results indicate a strong correlation between long-run growth, and effective enforcement of antitrust, and competition policy.Environmental Economics&Policies,Economic Theory&Research,ICT Policy and Strategies,Labor Policies,Decentralization,Economic Theory&Research,Environmental Economics&Policies,ICT Policy and Strategies,Achieving Shared Growth,Governance Indicators

Regulatory reform, competition, and innovation - a case study of the Mexican road freight industry

Discussions of competition and regulatory reform typically focus on price and quantity effects. But improving certain infrastructure services can also stimulate entry, and competition in user industries downstream, allowing new firms to enter, incumbent users to offer new products, and rivalry to intensify. The authors present a case study of how innovations in road freight services affect selected downstream users of those services after regulatory reform. After a period of rigid regulation, and heavy government interference, Mexico in 1989 developed a new policy framework for road transport, with free entry, and market-based price setting. The result: faster, more reliable trucking has allowed user companies to offer new, previously unavailable products, and to reach new areas with existing products. Cheaper, more customer-responsive trucking services have allowed logistical innovations in user firms, and some user firms have decided not to keep their own fleets of trucks, but to outsource trucking services on the open market, thereby converting fixed costs to variable costs. For one fertilizer company, the benefits of reform included a ten percent improvement in operating margin. Successful reform requires careful planning and execution, and political support at high levels. Regulatory reform also profoundly changes the sectoral institution formerly responsible for the regulation. Enough resources should be provided to help organizations in the reformed industry make the transition to the post-reform environment - helping with such tasks as defining the organization's new role, and facilitating the redeployment of staff. The national competition agency can help greatly in laying the groundwork for reform by making a compelling case for the reform's expected benefits. After reform, the competition agency should also help with enforcement, to ensure that the cozy, cartel-like behavior stimulated by tight entry restrictions does not persist. In Mexico, three strong interventions were required to discipline attempted anti-competitive practices in the trucking industry in the years following reform.Common Carriers Industry,Environmental Economics&Policies,Roads&Highways,Transport and Trade Logistics,Banks&Banking Reform,Roads&Highways,Transport and Trade Logistics,Common Carriers Industry,ICT Policy and Strategies,Environmental Economics&Policies

ENVIRONMENT, EQUITY AND WATERSHED MANAGEMENT

This paper presents a methodology for incorporating environmental and social equity objectives in an economic analysis of watershed management. Empirical results indicate that restricting agricultural pollution notably increases farm costs. The equity objective also adversely affects economic efficiency, but the cost increase due to social equity is less significant.Environmental Economics and Policy,

KINETIC AND KINEMATIC ANALYSIS OF RECURVE ARCHERY SHOOTING TECHNIQUE

The study investigated shooting techniques of the archers with kinetic and kinematic methods. Twenty-seven archers of different skill levels have been involved into the current study to investigate both muscular activation strategies of nine muscles and some kinematic data on drawing hand side. A statistical significant difference (p0.05) in the time-dependent exchange values of the angle of the joints, a difference was detected in the graphical sense. Elite archers use distal muscles less but proximal and axial muscles more, and mid-level and novice archers use distal muscles more to pull the bowstring. This was interpreted to be the most important factor affecting the horizontal oscillation (lateral diflection) of bowstring

THE EFFECTS OF WHOLE BODY VIBRATION ON POSTURAL CONTROL: THE FREQUENCY OF STIMULATION

This study investigated the efficacy of high and low-frequency acute whole-body vibration (WBV) on postural control ability. WBV stimulus were applied the following determinants: (1) type (vertical) (2) frequency (30 and 40 Hz), (3) stance position (static squat position), (4) amplitude (4mm mm), (5) knee flexion angle (120°) and time (60s).Motion of the point of application of the vertical component [medio-lateral (ML) and anterio-posterior (AP)] of the ground reaction force (center of pressure, COP). The study results showed that static WBV stimuli given at low and high frequencies and 4 mm amplitude resulted in a different postural adaptation (

A guide to mechanobiology: Where biology and physics meet

AbstractCells actively sense and process mechanical information that is provided by the extracellular environment to make decisions about growth, motility and differentiation. It is important to understand the underlying mechanisms given that deregulation of the mechanical properties of the extracellular matrix (ECM) is implicated in various diseases, such as cancer and fibrosis. Moreover, matrix mechanics can be exploited to program stem cell differentiation for organ-on-chip and regenerative medicine applications. Mechanobiology is an emerging multidisciplinary field that encompasses cell and developmental biology, bioengineering and biophysics. Here we provide an introductory overview of the key players important to cellular mechanobiology, taking a biophysical perspective and focusing on a comparison between flat versus three dimensional substrates. This article is part of a Special Issue entitled: Mechanobiology

Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase

APOBEC3B (A3B) is aberrantly overexpressed in a subset of breast cancers, where it associates with advanced disease, poor prognosis, and treatment resistance, yet the causes of A3B dysregulation in breast cancer remain unclear. Here, A3B mRNA and protein expression levels were quantified in different cell lines and breast tumors and related to cell cycle markers using RT-qPCR and multiplex immunofluorescence imaging. The inducibility of A3B expression during the cell cycle was additionally addressed after cell cycle synchronization with multiple methods. First, we found that A3B protein levels within cell lines and tumors are heterogeneous and associate strongly with the proliferation marker Cyclin B1 characteristic of the G2/M phase of the cell cycle. Second, in multiple breast cancer cell lines with high A3B, expression levels were observed to oscillate throughout the cell cycle and again associate with Cyclin B1. Third, induction of A3B expression is potently repressed throughout G0/early G1, likely by RB/E2F pathway effector proteins. Fourth, in cells with low A3B, induction of A3B through the PKC/ncNF-κB pathway occurs predominantly in actively proliferating cells and is largely absent in cells arrested in G0. Altogether, these results support a model in which dysregulated A3B overexpression in breast cancer is the cumulative result of proliferation-associated relief from repression with concomitant pathway activation during the G2/M phase of the cell cycle.</p

Frequency of Peripheral CD8+ T Cells Expressing Chemo-Attractant Receptors CCR1, 4 and 5 Increases in NPC Patients with EBV Clearance upon Radiotherapy

Radiotherapy (RT) is the standard-of-care for Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), where the post-RT clearance of plasma EBV DNA is prognostic. Currently, it is not known whether the post-RT clearance of plasma EBV DNA is related to the presence of circulating T-cell subsets. Blood samples from NPC patients were used to assess the frequency of T-cell subsets relating to differentiation, co-signaling and chemotaxis. Patients with undetectable versus detectable plasma EBV DNA levels post-RT were categorized as clearers vs. non-clearers. Clearers had a lower frequency of PD1+CD8+ T cells as well as CXCR3+CD8+ T cells during RT compared to non-clearers. Clearers exclusively showed a temporal increase in chemo-attractant receptors CCR1, 4 and/or 5, expressing CD8+ T cells upon RT. The increase in CCR-expressing CD8+ T cells was accompanied by a drop in naïve CD8+ T cells and an increase in OX40+CD8+ T cells. Upon stratifying these patients based on clinical outcome, the dynamics of CCR-expressing CD8+ T cells were in concordance with the non-recurrence of NPC. In a second cohort, non-recurrence associated with higher quantities of circulating CCL14 and CCL15. Collectively, our findings relate plasma EBV DNA clearance post-RT to T-cell chemotaxis, which requires validation in larger cohorts.</p