The effects of acute exercise bouts on hepcidin in women.

Item does not contain fulltextPURPOSE: To investigate the effects of acute exercise on serum hepcidin and iron (sFe) in active women. Changes in interleukin-6 (IL-6), hepcidin, ferritin, and sFe in response to 2 different exercise durations were compared. METHODS: Twelve women age 19-32 yr performed 2 treadmill runs (60 and 120 min) at 65% of VO2max. Blood samples were obtained before, immediately after, and 3, 6, 9, and 24 hr after exercise. Two-way repeated-measures ANOVA was conducted to examine changes in measured variables. Significance was accepted at p < .05. RESULTS: Significant effects for trial were observed for hepcidin (60 min: 1.15 +/- 0.48 nmol/L; 120 min: 2.28 +/- 1.44 nmol/L) and for time, with hepcidin significantly increased 3 hr postexercise in both trials (60 min: 3 hr - 1.99 +/- 2.00 nmol/L; 120 min: 3 hr - 4.60 +/- 4.61 nmol/L). Significant main effects for time occurred for sFe, ferritin, and IL-6. sFe was significantly decreased 9 hr postexercise compared with 3 and 24 hr postexercise. IL-6 was significantly increased immediately postexercise. CONCLUSIONS: Both runs resulted in significant increases in hepcidin 3 hr after exercise. Increases in hepcidin were preceded by significant increases in IL-6 immediately postexercise and followed by significant decreases in sFe 9 hr postexercise. It was concluded that endurance exercise increases the production of hepcidin, which affects sFe. The 2-hr exercise bout stimulated greater changes in serum hepcidin than the 1-hr bout.1 april 201

Fluid-Electrolyte Balance Associated with Tennis Match Play in a Hot Environment

Twenty (12 male and 8 female) tennis players from two Division I university tennis teams performed three days of round-robin tournament play (i.e., two singles tennis matches followed by one doubles match per day) in a hot environment (32.2 ±and 53.9 ± 2.4% rh at 1200 hr), so that fluid-electrolyte balance could be evaluated. During singles play, body weight percentage changes were minimal and were similar for males and females (males -1.3 ± 0.8%, females -0.7 ± 0.8%). Estimated daily losses (mmol ·) of sweat sodium (Na+) and potassium (K+) (males,158.7,31.3; females,86.5,18.9) were met by the players' daily dietary intakes (mmol ·) of these electrolytes (males,279.1 ± 109.4,173.5 ± 57.7; females,178.9 ± 68.9,116.1 ± 37.5). Daily plasma volume and electrolyte (Na+,) levels were generally conserved, although, plasma [Na+] was lower (p< .05) on the morning of Day 4. This study indicated that these athletes generally maintained overall fluid-electrolyte balance, in response to playing multiple tennis matches on 3 successive days in a hot environment, without the occurrence of heat illness