8 research outputs found
Housworth-Moseley House
Prepared by the Fall 2007 Conservation of Historic Building Materials Class. This historic structure report details the history, current condition, and future treatment and use for the Houseworth-Moseley house located in the Klondike Community of Southern Dekalb County, Georgia. The home was built approximately 1843.https://scholarworks.gsu.edu/history_heritagepreservation/1019/thumbnail.jp
Kennesaw Avenue and Moon-Holland Historic District
Prepared by the Spring 2007 Preservation Planning class. The design guidelines contain a brief history of Marietta. These design guidelines are specific to the Kennesaw Avenue and Moon-Holland historic District Boundaries. The purpose of the design guidelines is to aid residents, developers, and members of the Historic Preservation Commission in making effective decisions regarding rehabilitation and growth within the historic districts as detailed in the guidelines.https://scholarworks.gsu.edu/history_heritagepreservation/1020/thumbnail.jp
Kennesaw Avenue and Moon-Holland Historic District
Prepared by the Spring 2007 Preservation Planning class. The design guidelines contain a brief history of Marietta. These design guidelines are specific to the Kennesaw Avenue and Moon-Holland historic District Boundaries. The purpose of the design guidelines is to aid residents, developers, and members of the Historic Preservation Commission in making effective decisions regarding rehabilitation and growth within the historic districts as detailed in the guidelines.https://scholarworks.gsu.edu/history_heritagepreservation/1020/thumbnail.jp
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Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension
ObjectivesTo identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with patients with AAT deficiency elsewhere.Study designThe Childhood Liver Disease Research Network Longitudinal Observational Study of Genetic Causes of Intrahepatic Cholestasis is a prospective, cohort study of pediatric cholestatic liver diseases, including AAT deficiency, enrolling PIZZ and PISZ subjects 0-25 years of age seen since November 2007 at 17 tertiary care centers in the US and Canada. Data from standard-of-care baseline and annual follow-up visits were recorded from medical records, history, physical examination, and laboratory studies. Participants with portal hypertension were identified based on data collected.ResultsWe enrolled 350 participants (60% male) with a native liver; 278 (79%) entered the cohort without portal hypertension and 18 developed portal hypertension during follow-up. Thirty participants required liver transplantation; 2 patients died during 1077 person-years of follow-up. There was no difference in participants with or without preceding neonatal cholestasis progressing to transplantation or death during the study (12% vs 7%; P = .09), or in experiencing portal hypertension (28% vs 21%; P = .16); the hazard ratio for neonatal cholestasis leading to portal hypertension was P = .04. Development of portal hypertension was associated with a reduced height Z-score.ConclusionsPortal hypertension in youth with AAT deficiency impacts growth measures. Progression to liver transplantation is slow and death is rare, but the risk of complications and severe liver disease progression persists throughout childhood. A history of neonatal cholestasis is a weak predictor of severe disease