Ultrasound-assisted Synthesis of Some New Curcumin Analogues and Their Corresponding Pyrazoline Derivatives

In this work, a series of new curcumin mono-carbonyl analogs containing benzyloxy moieties and their pyrazoline derivatives were synthesized using a green method (ultrasound assisted technique) along with traditional method.  The work also includes a comparison between the two methods together and with literature.  Remarkable improvements were achieved by dropping down the reaction time from hours to minutes and obtaining higher yields of the products.

Synthesis and Characterization of Some New 4,5-Dihydropyrazolyl Thiazoles

Abstract: The prepared starting material 2,4-bis (4-chlorobenzyloxy)acetophenone (1) has been reacted with different substituted benzaldehydes to give a series of new chalcones (2a-j). The prepared new chalcones were subjected to react with thiosemicarbazide according to the Michael addition reaction to afford new thiocarbamoylpyrazoline derivatives (3a-j). A thiocarbamoyl group in compounds (3a-j) was cyclized with p-bromophenacyl bromide to give a series of new 4,5-dihydropyrazolyl thiazoles (4a-j). The structures of the synthesized compounds were characterized by spectral methods: FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra

Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives

A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-(substituted-phenyl)-1-substituted-2-pyrazolines( 4a-j) and (5a-j) have been synthesized by diazotization of 2-chloroaniline and its coupling reaction with 4-hydroxy acetophenone, followed by benzyloxation of the hydroxyl group to give the substrate [4-benzyloxy-3-(2-chlorophenylazo)-acetophenone (1)].The prepared starting material (1) has been reacted with different substituted benzaldehydes to give a new series of chalcone derivatives 1-[(4-benzyloxy)-3-(2-chloro-phenylazo)-phenyl]-3-(substituted phenyl)-2-propen-1-one (3a-j), in high yields and in a few minutes, and the later compounds were treated with hydrazine hydrate according to Michael addition reaction to afford a new biolological active target compounds (4a-j) and (5a-j). Furthermore, The structures of the newly synthesized compounds were confirmed by FT-IR, 13C-NMR,13C-DEPT & 1H-NMR spectral data. The chalcone and pyrazoline derivatives were evaluated for their anti bacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive, the results showed significant activity against both types of bacteria

Crystal structure of (6E,20E)-3,24-difluoro-13,14,28,29-tetrahydro-5H,22H-tetrabenzo[e,j,p,u][1,4,12,15]tetraoxacyclodocosine-5,22-dione

The conformation of the title compound, C34H26F2O6, is cone-shaped, partially determined by intramolecular C-H center dot center dot center dot O short contacts. The benzene rings at the top of the cone are inclined to one another by 73.10 (7)degrees, while the benzene rings at the bottom of the cone are inclined to one another by 35.49 (8)degrees. In the crystal, molecules are linked by C-H center dot center dot center dot O and C-H center dot center dot center dot F hydrogen bonds, forming a three-dimensional supramolecular structure. There are also C-H center dot center dot center dot pi contacts present within the framework structure

The structure of 9-(3-bromo-6-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,6-diphenyl-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione

In the structure of the title compound C33H29BrClNO4, (I), the hexahydro-2H-acridine ring system has a hydroxyethyl substituent on the N atom and a 3-bromo-6-chloro-2-hydroxyphenyl substituent on the central C atom at the 9-position. An unusual feature of the molecule is that the substituents at the 3- and 5-positions of the outer cyclohexenone rings are phenyl rings rather than the more common dimethyl substituents. C atoms on both of the cyclohexenone rings are disordered over two sites. In the crystal structure, O—H...O, C—H...O and C—H...π(ring) hydrogen bonds combine with an Br—O and unusual C—Br...π(ring) halogen bonds to generate a three dimensional network with molecules stacked along the a-axis direction

3-Hydroxy-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

The conformation of the title molecule, C16H12N2O3, is partly determined by an intramolecular C=O...π interaction between one carbonyl group and the five-membered ring of the other indolinone moiety. The crystal packing consists of layers parallel to (001) formed by a combination of N—H...O and O—H...O hydrogen bonds and π–π stacking interactions. Both the N—H...O and O—H...O hydrogen bonds generate inversion dimers

Bis(2-formyl­phen­yl) benzene-1,2-di­carboxyl­ate

The asymmetric unit of the title compound, C22H14O6, consists of two independent molecules differing in the orientations of the ester groups. In one molecule, the two terminal benzene rings are inclined to the central benzene ring by 4.99 (13) and 77.46 (13)°, while in the other the corresponding angles are 11.03 (13) and 88.09 (12)°. In the crystal, molecules are connected into a ribbon structure running along [101] via C—H...O and C—H...π interactions. Adjacent ribbons are further linked by additional C—H...O and C—H...π interactions. The crystal studied was a non-merohedral twin [twin law (0.986 − 0.073 − 0.008, 0.323 1.036 0.148, −0.121 − 0.102 0.942)], the ratio of components being 0.937 (4):0.063 (4)

4-(3-Methylphenyl)-3-[(3-methyl-5-phenyl-1H-pyrazol-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione

The title compound, C20H19N5S, adopts a `contorted' conformation and the dihedral angle between the heterocyclic rings is 86.54 (6)°. In the crystal, complementary N—H...N hydrogen bonds form centrosymmetric dimers, which generate R22(14) loops. The dimers stack along the a-axis direction with adjacent stacks having their aromatic rings directed towards one another

Crystal structure and Hirshfeld surface analysis of 3-[(1E)-(4-{4-[(E)-(3-hydroxybenzylidene)amino]-phenoxy}phenylimino)methyl]phenol

In the crystal, the molecule of the title compound, C26H20N2O3, has crystallographically imposed twofold rotation symmetry. The crystal packing consists of layers parallel to the ab plane formed by O-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds. Between the layers, C-H center dot center dot center dot pi interactions are observed

5-{[5-(4-Chlorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1,3,4-oxadiazole-2(3H)-thione

In the title compound, C13H11ClN4OS, the oxadiazolethione ring is inclined to the pyrazole ring by 79.2 (2)°. The 4-chlorophenyl ring is rotationally disordered, with the two fragments inclined to one another by 27.1 (4)°, and to the pyrazole ring by 43.1 (3) and 68.6 (3)°. In the crystal, molecules are linked by pairs of N—H...N hydrogen bonds, forming inversion dimers, enclosing an R22(14) ring motif. The dimers are linked by C—H...N hydrogen bonds, forming ribbons propagating along the a-axis direction and enclosing R22(8) ring motifs. The ribbons are linked by C—H...Cl hydrogen bonds, forming a three-dimensional supramolecular structure