Clustering of DIRBE Light and IR Background

We outline a new method for estimating the cosmic infrared background using the spatial and spectral correlation properties of infrared maps. The cosmic infrared background from galaxies should have a minimum fluctuation of the order of 10\% on angular scales of the order of 1\deg. We show that a linear combination of maps at different wavelengths can greatly reduce the fluctuations produced by foreground stars, while not eliminating the fluctuations of the background from high redshift galaxies. The method is potentially very powerful, especially at wavelengths where the foreground is bright but smooth.Comment: 7 pages postcript, talk at "Unveiling the cosmic infrared background" workshop, College Park, M

An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma

The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced tumor state and a poor prognosis. This suggests that MMB could contribute to tumorigenesis by mediating overexpression of mitotic genes. However, although MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis in vivo has not been investigated. Here we demonstrate that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS. We also identify a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis. RNA interference-mediated depletion of KIF23 inhibited lung tumor formation in vivo and induced apoptosis in lung cancer cell lines. Our results suggest that inhibition of KIF23 could be a strategy for treatment of lung cancer

Hydrogeochemistry of a wetland area of southwestern Sicily (Italy)

The “Preola” and “Gorghi tondi” lakes are the most noticeable wetlands in the Mazara del Vallo territory (south-west Sicily). There are four karst origin lakes located in a natural depression formed by gypsum dissolution and subsequent collapse of the “Calcarenite di Marsala”, a few meters above sea level. Erosion of the depression sides and human activity has caused visible colluvial deposits, which have contributed to a natural filling process of the lakes. A hydrogeological map of the area and the reconstruction of a water circulation model supplying the lakes have been drafted from geochemical and hydrogeological data. It is apparent from 18O values that the well waters are mainly fed by local meteoric water circulating within the calcarenitic aquifer. However, the lake waters chemical composition are very likely controlled by evaporation processes and a complex mixing between seawater and groundwater, depending on seasonal variation in the hydrodynamic equilibrium

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process. To determine which Ets factors are the targets of Ras signaling pathways, the abilities of several Ets factors to activate Ras-responsive enhancer (RRE) reporters in the presence of oncogenic Ras were examined. In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated 30-fold in NIH 3T3 fibroblasts and 80-fold in the macrophage-like line RAW264 by the combination of Ets1 or Ets2 and Ras but not by several other Ets factors that were tested in the assay. Ets2 and Ras also superactivated an RRE composed of Ets-Ets binding sites, but the Ets-responsive promoter of the c-fms gene was not superactivated. Mutation of a threonine residue to alanine in the conserved amino-terminal regions of Ets1 and Ets2 (threonine 38 and threonine 72, respectively) abrogated the ability of each of these proteins to superactivate reporter gene expression. Phosphoamino acid analysis of radiolabeled Ets2 revealed that Ras induced normally absent threonine-specific phosphorylation of the protein. The Ras-dependent increase in threonine phosphorylation was not observed in Ets2 proteins that had the conserved threonine 72 residue mutated to alanine or serine. These data indicate that Ets1 and Ets2 are specific nuclear targets of Ras signaling events and that phosphorylation of a conserved threonine residue is a necessary molecular component of Ras-mediated activation of these transcription factors

Fully Electrified Neugebauer Spacetimes

Generalizing a method presented in an earlier paper, we express the complex potentials E and Phi of all stationary axisymmetric electrovac spacetimes that correspond to axis data of the form E(z,0) = (U-W)/(U+W) , Phi(z,0) = V/(U+W) , where U = z^{2} + U_{1} z + U_{2} , V = V_{1} z + V_{2} , W = W_{1} z + W_{2} , in terms of the complex parameters U_{1}, V_{1}, W_{1}, U_{2}, V_{2} and W_{2}, that are directly associated with the various multipole moments. (Revised to clarify certain subtle points.)Comment: 25 pages, REVTE

Severe discrepancies between experiment and theory in the superconducting proximity effect

The superconducting proximity effect is investigated for SN double layers in a regime where the resulting transition temperature T_{c} does not depend on the mean free paths of the films and, within limits, not on the transparency of the interface. This regime includes the thin film limit and the normalized initial slope S_{sn}= (d_{s}/T_{s})|dT_{c}/dd_{n}|. The experimental results for T_{c} are compared with a numerical simulation which was recently developed in our group. The results for the SN double layers can be devided into three groups: (i) When N = Cu, Ag, Au, Mg a disagreement between experiment and theory by a factor of the order of three is observed, (ii) When N = Cd, Zn, Al the disagreement between experiment and theory is reduced to a factor of about 1.5, (iii) When N = In, Sn a reasonably good agreement between experiment and theory is observed

Observables for spacetimes with two Killing field symmetries

The Einstein equations for spacetimes with two commuting spacelike Killing field symmetries are studied from a Hamiltonian point of view. The complexified Ashtekar canonical variables are used, and the symmetry reduction is performed directly in the Hamiltonian theory. The reduced system corresponds to the field equations of the SL(2,R) chiral model with additional constraints. On the classical phase space, a method of obtaining an infinite number of constants of the motion, or observables, is given. The procedure involves writing the Hamiltonian evolution equations as a single `zero curvature' equation, and then employing techniques used in the study of two dimensional integrable models. Two infinite sets of observables are obtained explicitly as functionals of the phase space variables. One set carries sl(2,R) Lie algebra indices and forms an infinite dimensional Poisson algebra, while the other is formed from traces of SL(2,R) holonomies that commute with one another. The restriction of the (complex) observables to the Euclidean and Lorentzian sectors is discussed. It is also shown that the sl(2,R) observables can be associated with a solution generating technique which is linked to that given by Geroch.Comment: 23 pages (LateX-RevTeX), Alberta-Thy-55-9

Determining parameters of the Neugebauer family of vacuum spacetimes in terms of data specified on the symmetry axis

We express the complex potential E and the metrical fields omega and gamma of all stationary axisymmetric vacuum spacetimes that result from the application of two successive quadruple-Neugebauer (or two double-Harrison) transformations to Minkowski space in terms of data specified on the symmetry axis, which are in turn easily expressed in terms of multipole moments. Moreover, we suggest how, in future papers, we shall apply our approach to do the same thing for those vacuum solutions that arise from the application of more than two successive transformations, and for those electrovac solutions that have axis data similar to that of the vacuum solutions of the Neugebauer family. (References revised following response from referee.)Comment: 18 pages (REVTEX