1 research outputs found
Bacteriospermia, extended spectrum beta lactamase producing Gram-negative bacteria and other factors associated with male infertility in Mwanza, Tanzania: a need of diagnostic bacteriology for management of male infertility
Background: Infections caused by Extended spectrum beta lactamase
(ESBL) producing bacterial are global challenge. There is limited
information on the magnitude of bacteriospermia, ESBL producing
Gram-negative bacteria (GNB) causing bacteriospermia and factors
associated with male infertility. This study determined magnitude of
bacteriospermia, ESBL-GNB and other factors association with
infertility among presumptive infertile men in Mwanza, Tanzania.
Methods: A cross-sectional hospital-based study was conducted between
May 2017 and July 2018 among 137 presumptive infertile men. Semen
specimens were self-collected by masturbation into clean, sterile and
none-spermicidal containers and processed following laboratory standard
operating procedures (SOPs). Data analysis was done using STATA 13.0.
Results: Gram-negative bacteria were predominantly isolated (86.4%), of
which 31.6% were ESBL producers. In a total 44 bacteria were isolated
from semen culture. The blaCTX-M gene was detected in 75% of
phenotypically confirmed ESBL producers. Infertility was independently
found to be associated with abnormal spermatozoa morphology (OR
(95%CI): 14.48(3.17-66.05)) and abnormal spermatozoa motility (OR
(95%CI): 0.05(0.01-0.24)). However, neither bacteriospermia (OR
(95%CI): 0.86(0.29-2.59)) nor ESBL bacteriospermia (OR (95%CI):
0.13(0.01-1.22)) was found to be associated with infertility.
Conclusion: One third of bacteriospermia is due to ESBL-producers with
history of antibiotic use being protective factor for infertility.
Abnormal spermatozoa morphology and poor spermatozoa forward motility
independently predicted infertility