New skills, networks and challenges: the changing face of animal production science in Australia

Livestock producers are facing increasing pressure to reduce the environmental and animal-welfare impacts of production, while also managing the challenge of an increasingly variable climate and diminishing resources. This perspective paper highlights the role for animal scientists to contribute to the sustainability of future livestock systems. We argue the need for a broader, more inclusive and more integrated concept of animal science, better connections among scientists, producers, consumers and policy makers, and more support for the next generation of animal scientists. Animal scientists have an important role to play in providing the evidence to support the social licence of livestock production and inform decisions made by policy makers and consumers regarding the production and consumption of livestock products. Animal scientists can also assist producers to adapt to social, environmental and political challenges that affect their livelihoods and the way they farm. Traditionally, animal science has focussed on species- and discipline-specific areas of research such as ruminant nutrition, genetics or reproductive physiology. While this fundamental research remains essential to understand the underlying biology of livestock production and improve production efficiency, it needs to be better integrated into research applied at and beyond the herd or flock level. Systems thinkers who can apply this knowledge across farm, regional and national scales also have an important role in providing information to key decision makers, from farmers to national government. Better engagement with the social and economic sciences can inform how animal scientists and extension services interact with producers to understand constraints to production as well as adoption of new technology and co-develop evidence-based solutions. Underlying this, the demographics of those who study and work in animal science are changing. Australian animal industries require the best and brightest minds to overcome future challenges and engaging these students as the new face of Australian animal science is an essential step towards sustainable future livestock systems

Relationships between clean fleece weight, reproduction and fatness in adult Merino ewes and growth, fleece, carcase attributes and survival in their progeny

Concerns that high clean fleece weight (CFW) sheep were likely to be less fit during drought has been expressed by producers and has been supported to some degree by animal house experiments. These experiments predominantly used dry sheep, and found high fleece weight genotypes were leaner and had lower circulating energy levels. Conclusions from the experiments implied that reductions in reproduction will occur as a result of an emphasis on CFW selection. This thesis has examined the hypothesis that breeding ewes, selected for high or low CFW and high or low body weight and held at two levels of stocking rate, will partition nutrition differently with reductions evident in body fat and reproduction for high CFW animals. Also examined were the effects on carcase quality and growth in their offspring. Adult ewes (5-8 y.o.) were selected on the basis of their hogget CFW and hogget offshears body weight (BWT). Over two years, adult ewes were held at two levels of stocking rate throughout pregnancy and from marking to joining and liveweight, body fat score, ultrasound scanned fat and muscle depth and reproduction were recorded. The first drop of wether progeny were retained for slaughter to determine the effects on carcase quality and the first drop of ewe progeny were retained for measures of hogget fleece production. The final experiment examined controlled feed intake and metabolic energy reserves in the dams under animal house conditions, and the implications for rearing twin lambs

In-paddock walk-over weighing: understanding the factors affecting its potential for the Australian Sheep industry

The association between liveweight and a range of production and economic outcomes has been demonstrated in sheep production systems. Change in ewe liveweight affects her wool production, reproductive performance, survival and lifelong performance of her progeny. Similarly, liveweight in young sheep post-weaning is strongly associated with their survival. This breadth of sheep production parameters with demonstrated association with liveweight suggests that regular liveweight monitoring would provide a robust and versatile tool for managing sheep flocks. Walk-over weighing (WOW) technology has the potential to remotely monitor sheep liveweight either individually or collectively and is commercially available. It functions by collecting liveweight data as sheep voluntarily cross a weighing platform as part of their normal daily routine. The liveweight data is then collected, processed and interpreted by livestock managers to aid nutritional management. Despite the documented benefits of managing ewe liveweight, and the potential of WOW to aid ewe liveweight management, there is a paucity of literature on the subject. This thesis draws on a series of experiments, data analyses and economic models to investigate the factors affecting WOWs potential for commercial application

Introducing Health Promotion Agenda-Setting for Health Education Practitioners

Health professionals must continuously address health promotion issues using the latest strategies and research. Currently in health care, too often an underdeveloped and under supported agenda prioritizes problems, issues, and solutions. Further, an ongoing competition exists among issues due to an undocumented agenda-setting process to gain the attention of media, public, and policy makers. Agendasetting is based on the belief that the media influence what we talk about, rather than controlling what we think, and how often an issue appears in the media influences the policy agenda (Dearing & Rogers, 1996). If an issue is “salient” and receives frequent or expansive coverage by media, audience members will talk more about that issue than one that is not as salient. A Health Promotion Agenda-Setting approach works to specify and prioritize problems and alternative solutions for increasing media exposure and setting agendas for “sustained” courses of action, (Kozel et al., 2003). The crucial link between agenda-setting and the process of establishing effective legislation, policy, and programs has been researched. However, many health practitioners do not understand what agenda setting is, nor how to apply agenda setting within the field of health education. Professional development in Health Promotion Agenda-Setting offers health education practitioners new knowledge, skills, methods, and opportunities to strengthen practices that influence the public health agenda and transform health promotion leadership

Epirubicin, Cisplatin, and Capecitabine for Primary Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer: Results of a Retrospective, Single-Institution Study.

OBJECTIVE: Primary platinum-resistant epithelial ovarian cancer (EOC) is an area of unmet medical need. There is limited evidence from small studies that platinum-based combinations can overcome "resistance" in a proportion of patients. We investigated the efficacy and toxicity of platinum-based combination chemotherapy in the platinum-resistant and platinum-refractory setting. METHODS: Epirubicin, cisplatin, and capecitabine (ECX) combination chemotherapy was used at our institution for the treatment of relapsed EOC. From the institutional database, we identified all patients with primary platinum-refractory or platinum-resistant relapse treated with ECX as second-line therapy between 2001 and 2012. We extracted demographic, clinical, treatment, and toxicity data and outcomes. We used logistic and Cox regression models to identify predictors of response and survival respectively. RESULTS: Thirty-four 34 patients (8 refractory, 26 resistant) were treated with ECX. Response Evaluation Criteria In Solid Tumors (RECIST) response rate was 45%, median progression-free survival (PFS) was 6.4 months, and overall survival (OS) was 10.6 months. Platinum-resistant patients had better outcomes than did platinum-refractory patients (response rate, 54% vs 0%, P = 0.047; PFS 7.2 vs 1.8 months, P < 0.0001; OS 14.4 vs 3 months, P < 0.001). In regression models, time to progression after first-line treatment and platinum-refractory status were the strongest predictors of response and PFS or OS, respectively. Patients with time to progression after first-line treatment longer than 3 months showed PFS and OS of 7.9 and 14.7 months, respectively. Toxicity was manageable, with only 13% of cycles administered at reduced doses. CONCLUSIONS: Epirubicin, cisplatin, and capecitabine seems to be active in platinum-resistant relapsed EOC with manageable toxicity. Further prospective investigation of platinum-anthracycline combinations is warranted in patients who relapse 3 to 6 months after first-line platinum-taxane treatment

Sheep Updates 2009

This session covers seven papers from different authors: 1. Scouring Management and Worm Control, Brown Besier, Department of Agriculture and Food, Western Australia 2.Breeding sheep for resistance to breech strike:- Selection results in WA, LJE Karlsson, JC Greeff & AC Schlink, Department of Agriculture and Food, Western Australia 3.Future Ewe - matching genetics to the production system, Mark Ferguson, Department of Agriculture and Food, Western Australia 4. Within-flock selection of ewes: opportunities for gains in reproduction, Greg Leeand Sue Hatcher, NSW Department of Primary Industries & Australian CRCforSheep Industry Innovation (Orange) 5. Managing Merinos on Murrayfield, Bruce Michael, Murryfield, Bruny Island, Tasmania 6. Managing [breech] flystrike in [unmulesed] sheep, Rob Woodgate, Darren Michael, Mandy Curnow and Julia Smith, Department of Agriculture and Food, Western Australia 7. Value of Pregnancy Scanning and Differential Feeding of Dry, Single amd Twin Ewes, John Young, Farming Systems Analysis Service, Kojonup, WA, Andrew Thompson, Chris Oldham Department of Agriculture and Food, Western Australi

Sheep Updates 2005 - Part 4

This session covers twelve papers from different authors: REPRODUCTION 1. Is it worth increasing investment to increase lambing percentages? Lucy Anderton Department of Agriculture Western Australia. 2. What value is a lamb? John Young, Farming Systems Analysis Service, Kojonup, WA 3. Providing twin-bearing ewes with extra energy at lambing produces heavier lambs at marking. Rob Davidson WAMMCO International,, formerly University of Western Australia; Keith Croker, Ken Hart, Department of Agriculture Western Australia, Tim Wiese, Chuckem , Highbury, Western Australia. GENETICS 4. Underlying biological cause of trade-off between meat and wool. Part 1. Wool and muscle glycogen, BM Thomson, I Williams, University of WA, Crawley, JRBriegel, CSIRO Livestock Industries, Floreat Park WA &CRC for the Australian Sheep Industry, JC Greeff, Department of Agriculture Western Australia &CRC for the Australian Sheep Industry. 5. Underlying biological cause of trade-off between meat and wool. Part 2. Wool and fatness, NR Adams1,3, EN Bermingham1,3, JR Briegel1,3, JC Greeff2,3 1CSIRO Livestock Industries, Floreat Park WA 2Department of Agriculture Western Australia, 3CRC for the Australian Sheep Industry 6. Genetic trade-offs between lamb and wool production in Merino breeding programs, Johan Greeff, Department of Agriculture, Western Australia. 7. Clean fleece weight is no phenotypically independent of other traits. Sue Hatcherac and Gordon Refshaugebc aNSWDPI Orange Agricultural Institute, Orange NSW 2800 bUNE c/- NSWDPI Cowra AR&AS Cowra NSW 2794 cAustralian Sheep Industry CRC. 8. When you\u27re on a good thing, do it better: An economic analysis of sheep breed profitability. Emma Kopke, Ross Kingwell, Department of Agriculture, Western Australia, John Young, Farming Systems Analysis Service, Kojonup, WA. 9. Selection Demonstration Flocks: Demonstrating improvementsin productivity of merinos, K.E. Kemper, M.L. Hebart, F.D. Brien, K.S. Jaensch, R.J. Grimson, D.H. Smith South Australian Research and Development Institute 10. You are compromising yield by using Dust Penetration and GFW in breeding programs, Melanie Dowling, Department of Agriculture, Western Australia, A. (Tony) Schlink, CSIRO Livestock Industries, Wembley, Johan Greeff, Department of Agriculture Western Australia. 11. Merino Sheep can be bred for resistance to breech strike. Johan Greeff , John Karlsson, Department of Agriculture Western Australia 12. Parasite resistant sheep and hypersensitivity diarrhoea, L.J.E. Karlsson & J.C. Greeff, Department of Agriculture Western Australi

Working in the Public Interest Law Conference

Entirely student organized, WIPI seeks to bring together eminent practitioners in their respective fields, students, and faculty to discuss practical approaches to lawyering which can best serve the poor. Practical methods of challenging poverty are often not covered in traditional law school courses. This conference seeks to remedy that and provide dynamic, creative ways to combat poverty through the vehicle of the law

The Be Our Ally Beat Smoking (BOABS) study, a randomised controlled trial of an intensive smoking cessation intervention in a remote aboriginal Australian health care setting

Background: Australian Aboriginal and Torres Strait Islander peoples (Indigenous Australians) smoke at much higher rates than non-Indigenous people and smoking is an important contributor to increased disease, hospital admissions and deaths in Indigenous Australian populations. Smoking cessation programs in Australia have not had the same impact on Indigenous smokers as on non-Indigenous smokers. This paper describes the outcome of a study that aimed to test the efficacy of a locally-tailored, intensive, multidimensional smoking cessation program. Methods: A randomised controlled trial of Aboriginal researcher delivered tailored smoking cessation counselling during face-to-face visits, aiming for weekly for the first four weeks, monthly to six months and two monthly to12 months. The control (“usual care”) group received routine care relating to smoking cessation at their local primary health care service. Data collection occurred at enrolment, six and 12 months. The primary outcome was self-reported smoking cessation with urinary cotinine confirmation at final follow-up (median 13 (interquartile range 12–15) months after enrolment).Results: Participants in the intervention (n = 55) and usual care (n = 108) groups were similar in baseline characteristics, except the intervention group was slightly older. At final follow-up the smoking cessation rate for participants assigned to the intervention group (n = 6; 11%), while not statistically significant, was double that of usual care (n = 5; 5%; p = 0.131). A meta-analysis of these findings and a similarly underpowered but comparable study of pregnant Indigenous Australian women showed that Indigenous Australian participants assigned to the intervention groups were 2.4 times (95% CI, 1.01-5.5) as likely to quit as participants assigned to usual care. Conclusions: Culturally appropriate, multi-dimensional Indigenous quit smoking programs can be successfully implemented in remote primary health care. Intensive one-on-one interventions with substantial involvement from Aboriginal and Torres Strait Islander workers are likely to be effective in these settings. Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12608000604303)

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead