7,976 research outputs found
Emergent Antiferromagnetism in D-wave Superconductor with Strong Paramagnetic Pair-Breaking
It is theoretically shown that, in the four-fold symmetric d-wave
superconducting phase, a paramagnetic pair-breaking (PPB) enhanced sufficiently
by increasing the applied magnetic field induces not only the
Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) superconducting state but also an
incommensurate antiferromagnetic (AFM) order with Q-vector parallel to a gap
node. This AFM ordering tends to occur only below H_{c2} at low temperatures,
i.e., in the presence of a nonvanishing superconducting energy gap
rather than in the normal phase. Through a detailed study on the resulting AFM
order and its interplay with the FFLO spatial modulation of , it is
argued that the strange high field and low temperature (HFLT) superconducting
phase of CeCoIn_5 is a coexisting phase of the FFLO and incommensurate AFM
orders, and that this PPB mechanism of an AFM ordering is also the origin of
the AFM quantum critical fluctuation which has occurred close to H_{c2}(0) in
several unconventional superconductors including CeCoIn_5.Comment: 22 pages, 12 figures.2 references and related comnments are
added.Accepted for publication in Phys. Rev.
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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-phagocytic surface proteins called 'don't eat me' signals-including CD471, programmed cell death ligand 1 (PD-L1)2 and the beta-2 microglobulin subunit of the major histocompatibility class I complex (B2M)3. Monoclonal antibodies that antagonize the interaction of 'don't eat me' signals with their macrophage-expressed receptors have demonstrated therapeutic potential in several cancers4,5. However, variability in the magnitude and durability of the response to these agents has suggested the presence of additional, as yet unknown 'don't eat me' signals. Here we show that CD24 can be the dominant innate immune checkpoint in ovarian cancer and breast cancer, and is a promising target for cancer immunotherapy. We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is expressed by tumour-associated macrophages. We find that many tumours overexpress CD24 and that tumour-associated macrophages express high levels of Siglec-10. Genetic ablation of either CD24 or Siglec-10, as well as blockade of the CD24-Siglec-10 interaction using monoclonal antibodies, robustly augment the phagocytosis of all CD24-expressing human tumours that we tested. Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time. These data reveal CD24 as a highly expressed, anti-phagocytic signal in several cancers and demonstrate the therapeutic potential for CD24 blockade in cancer immunotherapy
Absorption-free optical control of spin systems:the quantum Zeno effect in optical pumping
We show that atomic spin motion can be controlled by circularly polarized
light without light absorption in the strong pumping limit. In this limit, the
pumping light, which drives the empty spin state, destroys the Zeeman coherence
effectively and freezes the coherent transition via the quantum Zeno effect. It
is verified experimentally that the amount of light absorption decreases
asymptotically to zero as the incident light intensity is increased.Comment: 4 pages with 4 figure
Motion-Induced Magnetic Resonance of Rb Atoms in a Periodic Magnetostatic Field
We demonstrate that transitions between Zeeman-split sublevels of Rb atoms
are resonantly induced by the motion of the atoms (velocity: about 100 m/s) in
a periodic magnetostatic field (period: 1 mm) when the Zeeman splitting
corresponds to the frequency of the magnetic field experienced by the moving
atoms. A circularly polarized laser beam polarizes Rb atoms with a velocity
selected using the Doppler effect and detects their magnetic resonance in a
thin cell, to which the periodic field is applied with the arrays of parallel
current-carrying wires.Comment: 4 pages, 4 figures; minor corrections, Ref. [9] removed, published in
PR
Velocity-selective sublevel resonance of atoms with an array of current-carrying wires
Resonance transitions between the Zeeman sublevels of optically-polarized Rb
atoms traveling through a spatially periodic magnetic field are investigated in
a radio-frequency (rf) range of sub-MHz. The atomic motion induces the
resonance when the Zeeman splitting is equal to the frequency at which the
moving atoms feel the magnetic field oscillating. Additional temporal
oscillation of the spatially periodic field splits a motion-induced resonance
peak into two by an amount of this oscillation frequency. At higher oscillation
frequencies, it is more suitable to consider that the resonance is mainly
driven by the temporal field oscillation, with its velocity-dependence or
Doppler shift caused by the atomic motion through the periodic field. A
theoretical description of motion-induced resonance is also given, with
emphasis on the translational energy change associated with the internal
transition.Comment: 7 pages, 3 figures, final versio
Spin Nutation Induced by Atomic Motion in a Magnetic Lattice
An atom moving in a spatially periodic field experiences a temporary periodic
perturbation and undergoes a resonance transition between atomic internal
states when the transition frequency is equal to the atomic velocity divided by
the field period. We demonstrated that spin nutation was induced by this
resonant transition in a polarized rubidium (Rb) atomic beam passing through a
magnetic lattice. The lattice was produced by current flowing through an array
of parallel wires crossing the beam. This array structure, reminiscent of a
multiwire chamber for particle detection, allowed the Rb beam to pass through
the lattice at a variety of incident angles. The dephasing of spin nutation was
reduced by varying the incident angle.Comment: 11 pages, 4 figures, submitted to Phys. Rev.
Ground-state electric quadrupole moment of 31Al
Ground-state electric quadrupole moment of 31Al (I =5/2+, T_1/2 = 644(25) ms)
has been measured by means of the beta-NMR spectroscopy using a spin-polarized
31Al beam produced in the projectile fragmentation reaction. The obtained Q
moment, |Q_exp(31Al)| = 112(32)emb, are in agreement with conventional shell
model calculations within the sd valence space. Previous result on the magnetic
moment also supports the validity of the sd model in this isotope, and thus it
is concluded that 31Al is located outside of the island of inversion.Comment: 5 page
Top-down estimate of a large source of atmospheric carbon monoxide associated with fuel combustion in Asia
We simulate the oceanic and atmospheric distribution of methyl iodide (CH3I) with a global 3-D model driven by assimilated meteorological observations from the Goddard Earth Observing System of the NASA Data Assimilation Office and coupled to an oceanic mixed layer model. A global compilation of atmospheric and oceanic observations is used to constrain and evaluate the simulation. Seawater CH3I(aq) in the model is produced photochemically from dissolved organic carbon, and is removed by reaction with Clâ and emission to the atmosphere. The net oceanic emission to the atmosphere is 214 Gg yrâ1. Small terrestrial emissions from rice paddies, wetlands, and biomass burning are also included in the model. The model captures 40% of the variance in the observed seawater CH3I(aq) concentrations. Simulated concentrations at midlatitudes in summer are too high, perhaps because of a missing biological sink of CH3I(aq). We define a marine convection index (MCI) as the ratio of upper tropospheric (8â12 km) to lower tropospheric (0â2.5 km) CH3I concentrations averaged over coherent oceanic regions. The MCI in the observations ranges from 0.11 over strongly subsiding regions (southeastern subtropical Pacific) to 0.40 over strongly upwelling regions (western equatorial Pacific). The model reproduces the observed MCI with no significant global bias (offset of only +11%) but accounts for only 15% of its spatial and seasonal variance. The MCI can be used to test marine convection in global models, complementing the use of radon-222 as a test of continental convection.Engineering and Applied Science
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