A specification patterns system for discrete event systems analysis

As formal verification tools gain popularity, the problem arises of making them more accessible to engineers. A correct understanding of the logics used to express properties of a system's behavior is needed in order to guarantee that properties correctly encode the intent of the verification process. Writing appropriate properties, in a logic suitable for verification, is a skillful process. Errors in this step of the process can create serious problems since a false sense of safety is gained with the analysis. However, when compared to the effort put into developing and applying modeling languages, little attention has been devoted to the process of writing properties that accurately capture verification requirements. In this paper we illustrate how a collection of property patterns can help in simplifying the process of generating logical formulae from informally expressed requirements

Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines

Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor coat proteins gp3, gp6, gp7 and gp9. Inovirus display studies have shown that the architecture of inoviruses makes all coat proteins of the inoviral particle accessible to the outside. This particular feature of IAVs allows foreign antigenic peptides to be displayed on the outer surface of the virion fused to its coat proteins and for more than two decades has been exploited in many applications including antibody or peptide display libraries, drug design, and vaccine development against infectious and non-infectious diseases. As vaccine carriers, IAVs have been shown to elicit both a cellular and humoral response against various pathogens through the display of antibody epitopes on their coat proteins. Despite their high immunogenicity, the goal of developing an effective vaccine against HIV-1 has not yet materialized. One possible limitation of previous efforts was the use of broadly neutralizing antibodies, which exhibited autoreactivity properties. In the past five years, however, new, more potent broadly neutralizing antibodies that do not exhibit autoreactivity properties have been isolated from HIV-1 infected individuals, suggesting that vaccination strategies aimed at producing such broadly neutralizing antibodies may confer protection against infection. The utilization of these new, broadly neutralizing antibodies in combination with the architectural traits of IAVs have driven the current developments in the design of an inovirus-based vaccine against HIV-1. This article reviews the applications of IAVs in vaccine development, with particular emphasis on the design of inoviral-based vaccines against HIV-1

Unit roots and long-run causality The case of output and financial variables

SIGLEAvailable from British Library Document Supply Centre- DSC:3597.3859(LBS-CEF-DP--14-95) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Real-time Monitoring of Behavioural Parameters Related to Psychological Stress

We have developed a system, allowing real-time monitoring of human gestures, which can be used for the automatic recognition of behavioural correlates of psychological stress. The system is based on a low-cost camera (Microsoft Kinect), which provides video recordings capturing the subject's upper body activity. Motion History Images (MHIs) are calculated in real-time from these recordings. Appropriate algorithms are thereafter applied over the MHIs, enabling the real-time calculation of activity-related behavioural parameters. The system's efficiency in real-time calculation of behavioural parameters has been tested in a pilot trial, involving monitoring of behavioural parameters during the induction of mental stress. Results showed that our prototype is capable to effectively calculate simultaneously eight different behavioural parameters in real-time. Statistical analysis indicated significant correlations between five of these parameters and self-reported stress. The preliminary findings suggest that our approach could potentially prove useful within systems targeting automatic stress detection, through unobtrusive monitoring of subjects