Myocardial infarction following COVID-19 vaccine administration; a systematic review.

IntroductionCovid-19 vaccines have been assessed in randomized trials, which are designed to establish efficacy and safety, but are insufficient in power to detect rare adverse outcomes. Among the adverse cardiac events associated with mRNA COVID-19 vaccines are inflammations (e.g., pericarditis or myocarditis), thrombosis, and ischemia.ObjectiveThis systematic review aims to evaluate the reported cases of myocardial infarction (MI) after COVID-19 vaccinations.MethodWeb of Science, MEDLINE on OVID, PubMed, and Google Scholar were searched for English-language papers published until March 25, 2022.ResultsThis study included 15 papers (10 case reports and 5 case series). In total, 20 individuals were included who had received COVID-19 vaccines and experienced MI. Males (55%) reported more adverse occurrences than females (45%) across the majority of event categories. The mean time from the administration of the vaccine to the onset of symptoms was 2 days (0-10 days). The AstraZeneca vaccine was responsible for more than half of the reported events. In the majority of cases, the event developed after receiving the first dose of vaccination.ConclusionMI related to COVID19 vaccination is a rare, but serious and life-threatening condition. Chest discomfort should be regarded as a warning sign, particularly in people who have been administered a dose of the vaccine within the previous two days

Pilonidal sinus of neck: a case report with literature review

Introduction: Pilonidal disease commonly occurs in the sacrococcigeal area. Rarely it may occur in the face, interdigital region, groin, and umbilicus. The aim of this report is to present and discuss a new case of pilonidal sinus of neck with literature review.Methods: Case report.Results: A 37-year-old male, presented with a discharging sinus in the left posterior triangle of the neck for six month duration. Under local anesthesia, excision of the sinus with primary closure was performed. Histopathological examination showed features consistent with pilonidal sinus. Two months later, the wound completely healed. The patient was followed up for the next 4 months with no signs of recurrence.Conclusion: Neck pilonidal sinus is a rare variant of pilonidal disease presenting as chronic discharging sinus. The main treatment strategy is excision and primary closure

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality