Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template

Improvements in our understanding of the functions of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) subtypes as pleiotropic regulators of biological responses, including lipid, lipoprotein, glucose homeostasis, inflammation, differentiation and proliferation of various cancer cells, and memory, have provided an opportunity to develop novel PPAR ligands with characteristic subtype selectivity. Such ligands are not only chemical tools to investigate the functions of PPARs, but also candidates for the treatment of PPAR-mediated diseases, including metabolic syndrome, inflammation, dementia, and cancer. This minireview summarizes our work on the design, synthesis, and pharmacological evaluation of subtype-selective PPAR agonists based on the use of 3,4-disubstituted phenylpropanoic acid as a versatile template

Additional kernel observer: privilege escalation attack prevention mechanism focusing on system call privilege changes

Cyberattacks, especially attacks that exploit operating system vulnerabilities, have been increasing in recent years. In particular, if administrator privileges are acquired by an attacker through a privilege escalation attack, the attacker can operate the entire system and cause serious damage. In this paper, we propose an additional kernel observer (AKO) that prevents privilege escalation attacks that exploit operating system vulnerabilities. We focus on the fact that a process privilege can be changed only by specific system calls. AKO monitors privilege information changes during system call processing. If AKO detects a privilege change after system call processing, whereby the invoked system call does not originally change the process privilege, AKO regards the change as a privilege escalation attack and applies countermeasures against it. AKO can therefore prevent privilege escalation attacks. Introducing the proposed method in advance can prevent this type of attack by changing any process privilege that was not originally changed in a system call, regardless of the vulnerability type. In this paper, we describe the design and implementation of AKO for Linux x86 64-bit. Moreover, we show that AKO can be expanded to prevent the falsification of various data in the kernel space. Then, we present an expansion example that prevents the invalidation of Security-Enhanced Linux. Finally, our evaluation results show that AKO is effective against privilege escalation attacks, while maintaining low overhead

The Stellar Mass, Star Formation Rate and Dark Matter Halo Properties of LAEs at z∼2z\sim2

We present average stellar population properties and dark matter halo masses of $z \sim 2$ \lya emitters (LAEs) from SED fitting and clustering analysis, respectively, using $\simeq$ $1250$ objects ($NB387\le25.5$) in four separate fields of $\simeq 1$ deg$^2$ in total. With an average stellar mass of $10.2\, \pm\, 1.8\times 10^8\ {\mathrm M_\odot}$ and star formation rate of $3.4\, \pm\, 0.4\ {\mathrm M_\odot}\ {\rm yr^{-1}}$, the LAEs lie on an extrapolation of the star-formation main sequence (MS) to low stellar mass. Their effective dark matter halo mass is estimated to be $4.0_{-2.9}^{+5.1} \times 10^{10}\ {\mathrm M_\odot}$with an effective bias of$1.22^{+0.16}_{-0.18}$which is lower than that of$z \sim 2$LAEs ($1.8\, \pm\, 0.3$), obtained by a previous study based on a three times smaller survey area, with a probability of$96\%. However, the difference in the bias values can be explained if cosmic variance is taken into account. If such a low halo mass implies a low HI gas mass, this result appears to be consistent with the observations of a high \lya escape fraction. With the low halo masses and ongoing star formation, our LAEs have a relatively high stellar-to-halo mass ratio (SHMR) and a high efficiency of converting baryons into stars. The extended Press-Schechter formalism predicts that at z=0$our LAEs are typically embedded in halos with masses similar to that of the Large Magellanic Cloud (LMC); they will also have similar SHMRs to the LMC, if their SFRs are largely suppressed after$z \sim 2$ as some previous studies have reported for the LMC itself.Comment: 34 pages, 15 figures, 6 tables. Accepted for publication in PAS