Energy Efficient and Intrinsically Linear Digital Polar Transmitters

One of the biggest challenges in modern transmitter (TX) design, when going from the fourth generation (4G) to fifth generation (5G) communications network, is to handle the increased linearity requirements without introducing any compromise in the energy efficiency of the TX line-up. In analog systems, high quality for the TX signal can be only achieved when using very linear operation of the (analog) power amplifier (PA). This severely limits the achievable efficiency in practical TX line-ups. Alternatively, a nonlinear PA can be used, which is linearized by digital pre-distortion (DPD) circuitry. This later approach is commonly used in (4G) macro-cell base stations, but it comes at the cost of increased system complexity and high supply power for the advanced DPD unit. When going towards 5G handset, or massive -multiple - input -multiple - output (mMIMO) 5G base station units, that facilitate beamforming and higher data rates to their end users. The required RF output power per individual transmitter is rather low (at most only a few watts). However, since many more transmitters are used in 5G applications (e.g. a factor 64 x to 256 x more than in 4G base stations) the use of an advanced DPD units in each individual TX-lineup, with their related high-power consumption becomes simply impractical. Consequently, to address these changing needs, it is highly desirable to find new circuit-level TX solutions, that overcome the traditional linearity-efficiency trade-off. To achieve this goal, this PhD work is focused on the utilization and tailoring of digital device operation, as facilitated by advanced CMOS technologies, towards the needs of modern wireless applications with their wideband complex modulated TX signals. The circuit techniques developed within this thesis, target an inherently linear amplitude-code-word (ACW) to TX output signal transfer, as such omitting completely the need for a power hungry advanced DPD unit, or alternatively, rely on a much more simple and consequently less power hungry DPD unit for the most demanding applications (e.g. when handling large modulation bandwidths). The circuit techniques developed in thesis, allow excellent drain and TX line-up efficiency, while being compatible with wideband efficiency enhancement techniques like Doherty. The proposed circuit techniques are also able to correct for process, voltage, load and temperature variations of the application.Electronic

Enhancing the efficiency of retail cash handling processes at Amsterdam Airport Schiphol

During the recent years, electronic payment methods have become more customary and in cases more preferable. Nevertheless, cash remains a popular form of payment due, inter alia, to its ubiquity. Large use of cash is associated with security issues, investment costs, logistics costs of transport and handling cash, personnel costs, and the like. To deal with these issues, many retailers have, to different extents, outsourced cash handling services to CiT companies. Kappe’ and Schiphol Airport Retail (SAR) are two retail groups functioning at a number of locations in Amsterdam Airport Schiphol. They currently outsource part of their cash handling services to ABN-AMRO and GWK-Travelex. This results in a further increase in costs incurred by Kappe’ and SAR. Consequently, enhancing the efficiency of money flow is of significant importance to both corporations. The aim of this research is to develop cash handling processes which can bring about a more efficiency. This is done firstly by conducting a literature review on the reasons behind large costs of cash handling for retailers. Then the current processes of cash handling at Kappe' and SAR are studied to explore their deficiencies. After that, alternatives (e.g. automation, joint cash office, clustering) which can bring about a more efficient cash handling process are proposed and assessed on criteria of interest to the problem owners (Kappe' and SAR). The implementation chapter is done for the selected alternative. In the next stage, the prudence of the selected processes is e-evaluated by using a multi-criteria analysis methodology and also based on the trends in customers’ use of cash in payments. Finally, given the findings of the research, recommendations are provided for future improvement in cash handling processes.Management of TechnologyTransport and logisticsTechnology, Policy and Managemen

A Highly Linear Wideband Polar Class-E CMOS Digital Doherty Power Amplifier

This article presents the first application of a digital-intensive intrinsically linear digitally controlled class-E technique in a Doherty configuration. By careful nonlinear segmentation and multiphase RF-clocking along with overdrive-voltage control and automatic duty-cycle correction, it is shown that even the nonlinearities related to Doherty operation can be fully handled by the underlying design such that digital predistorion (DPD) can be, in principle, omitted. The nonlinearity behavior of the whole digital Doherty power amplifier (PA) is analyzed, and closed-form equations are given to predict the AM-AM and AM-phase modulation (PM) curves. In addition, time/phase mismatch between the peak and main branches and the AM and PM signals is accurately compensated. In order to achieve the maximum intrinsic linearity, two separate chips with the same architecture, but different design parameters, are fabricated as the main and peak amplifiers in 40-nm bulk CMOS. To achieve a large RF bandwidth and high passive combiner efficiency, a differential low-loss, wideband Marchand balun-based Doherty power combiner, implemented using reentrant coupled lines with independent second-harmonic control is proposed, and together with the matching network is fabricated on a two-layer PCB. The measured peak/6-dB power backoff P OUT, drain efficiency/power-added efficiency at 2.4 GHz are 17.5 dBm/12.2 dBm, 57%/52% and 36%/25% with VDD main/peak = 0.6 V/0.7 V. Measured results without using DPD show -41-dBc adjacent channel power ratio (ACPR) and -36-dB error vector magnitude (EVM) for a 16-MHz OFDM signal at 2.5 GHz. By using DPD, the measured ACPR and EVM of a 16-MHz/32-MHz OFDM signals are -52 dBc/-48 dBc and -50 dB/-48 dB, respectively.Accepted author manuscriptElectronic

High-Power Digital Transmitters for Wireless Infrastructure Applications (A Feasibility Study)

Fully digital transmitters (DTXs) have the potential of replacing analog-intensive transmitter (TX) line-ups in future massive multiple-input and multiple-output (mMIMO) systems since they hold the promise of higher system integration level and energy efficiency. DTX operation so far has been limited to low RF output powers. This article introduces a concept that enables high-power DTX operation. A DTX demonstrator targeting both high output power and high efficiency is realized as a proof of concept. It is based on a custom <formula> <tex>${V_{T}}$</tex> </formula> -shifted laterally-diffused MOS (LDMOS) technology, which is utilized to implement a segmented high-power output stage operated in class-BE. A low-voltage high-speed 40-nm CMOS controller drives the individual output stage segments at gigahertz rates. Measurements show the promising results for the proposed high-power DTX concept and provide valuable lessons for future DTX implementations.Electronic

Rheological response of a modified polyacrylamide–silica nanoparticles hybrid at high salinity and temperature

Water-soluble polyacrylamides have often been used to modify flow response in various water-based technologies and industrial processes, including paints, water treatment, paper manufacturing, and chemical enhanced oil recovery. Polymers are susceptible to degradation at combined high salinity and elevated temperature conditions which limits their overall performance. Hybrid mixtures of hydrophobically modified polyacrylamide (HMPAM) with hydrophobically modified silica nanoparticles (NPs) emerged as a promising strategy for achieving enhanced stability and high viscosity in brines having a high total dissolved solids (TDS) content and high hardness at elevated temperatures (>20 wt% TDS, including >1.5 wt% divalent cations at T > 70 °C). The rheological response of the hybrids at various concentrations of HMPAM and NPs was examined to investigate the synergic effects. Hybridization of HMPAM with NPs led to a higher viscosity at high salinity and elevated temperature. The viscosity improvement was more pronounced when the concentration of HMPAM was in the semi-dilute regime and concentration of NPs was higher than a critical threshold where the viscosity increased roughly by a factor of 1.5. Here we present the mechanisms of improved viscosity behaviour. The rheological data suggest the role of NPs in the bridging between HMPAM molecules, which in turn increases the hydrodynamic radius and consequently the viscosity of the hybrids.Petroleum EngineeringChemE/Product and Process Engineerin

A Kalman filter approach to realize the lowest astronomical tide surface

In this paper, we present a novel Kalman filter approach to combine a hydrodynamic model-derived lowest astronomical tide (LAT) surface with tide gauge record-derived LAT values. In the approach, tidal water levels are assimilated into the model. As such, the combination is guided by the model physics. When validating the obtained “Kalman-filtered LAT realization” at all tide gauges, we obtained an overall root-mean-square (RMS) difference of 15.1 cm. At the tide gauges not used in the data assimilation, the RMS is 17.9 cm. We found that the assimilation reduces the overall RMS difference by ∼31% and ∼22%, respectively. In the Dutch North Sea and Wadden Sea, the RMS differences are 6.6 and 14.8 cm (all tide gauges), respectively. Furthermore, we address the problem of LAT realization in intertidal waters where LAT is not defined. We propose to replace LAT by pseudo-LAT, which we suggest to realize similarly as LAT except that all water level boundary conditions and assimilated tidal water levels have to be enlarged by a constant value that is removed afterwards. Using this approach, we obtained a smooth reference surface for the Dutch Wadden Sea that fits LAT at the North Sea boundary within a few centimeters.Physical and Space Geodes

Effective refractive error coverage in adults aged 50 years and older: estimates from population-based surveys in 61 countries

BACKGROUND: In 2021, WHO Member States endorsed a global target of a 40-percentage-point increase in effective refractive error coverage (eREC; with a 6/12 visual acuity threshold) by 2030. This study models global and regional estimates of eREC as a baseline for the WHO initiative. METHODS: The Vision Loss Expert Group analysed data from 565 448 participants of 169 population-based eye surveys conducted since 2000 to calculate eREC (met need/[met need + undermet need + unmet need]). A binary logistic regression model was used to estimate eREC by Global Burden of Disease (GBD) Study super region among adults aged 50 years and older. FINDINGS: In 2021, distance eREC was 79·1% (95% CI 72·4-85·0) in the high-income super region; 62·1% (54·7-68·8) in north Africa and Middle East; 49·5% (45·0-54·0) in central Europe, eastern Europe, and central Asia; 40·0% (31·7-48·2) in southeast Asia, east Asia, and Oceania; 34·5% (29·4-40·0) in Latin America and the Caribbean; 9·0% (6·5-12·0) in south Asia; and 5·7% (3·1-9·0) in sub-Saharan Africa. eREC was higher in men and reduced with increasing age. Global distance eREC increased from 2000 to 2021 by 19·0%. Global near vision eREC for 2021 was 20·5% (95% CI 17·8-24·4). INTERPRETATION: Over the past 20 years, distance eREC has increased in each super region yet the WHO target will require substantial improvements in quantity and quality of refractive services in particular for near vision impairment. FUNDING: WHO, Sightsavers, The Fred Hollows Foundation, Fondation Thea, Brien Holden Vision Institute, Lions Clubs International Foundation

Effective refractive error coverage in adults aged 50 years and older: estimates from population-based surveys in 61 countries

BACKGROUND: In 2021, WHO Member States endorsed a global target of a 40-percentage-point increase in effective refractive error coverage (eREC; with a 6/12 visual acuity threshold) by 2030. This study models global and regional estimates of eREC as a baseline for the WHO initiative. METHODS: The Vision Loss Expert Group analysed data from 565 448 participants of 169 population-based eye surveys conducted since 2000 to calculate eREC (met need/[met need + undermet need + unmet need]). A binary logistic regression model was used to estimate eREC by Global Burden of Disease (GBD) Study super region among adults aged 50 years and older. FINDINGS: In 2021, distance eREC was 79·1% (95% CI 72·4-85·0) in the high-income super region; 62·1% (54·7-68·8) in north Africa and Middle East; 49·5% (45·0-54·0) in central Europe, eastern Europe, and central Asia; 40·0% (31·7-48·2) in southeast Asia, east Asia, and Oceania; 34·5% (29·4-40·0) in Latin America and the Caribbean; 9·0% (6·5-12·0) in south Asia; and 5·7% (3·1-9·0) in sub-Saharan Africa. eREC was higher in men and reduced with increasing age. Global distance eREC increased from 2000 to 2021 by 19·0%. Global near vision eREC for 2021 was 20·5% (95% CI 17·8-24·4). INTERPRETATION: Over the past 20 years, distance eREC has increased in each super region yet the WHO target will require substantial improvements in quantity and quality of refractive services in particular for near vision impairment. FUNDING: WHO, Sightsavers, The Fred Hollows Foundation, Fondation Thea, Brien Holden Vision Institute, Lions Clubs International Foundation

Using a 29-mRNA Host Response Classifier To Detect Bacterial Coinfections and Predict Outcomes in COVID-19 Patients Presenting to the Emergency Department

Clinicians in the emergency department (ED) face challenges in concurrently assessing patients with suspected COVID-19 infection, detecting bacterial coinfection, and determining illness severity since current practices require separate workflows. Here, we explore the accuracy of the IMX-BVN-3/IMX-SEV-3 29 mRNA host response classifiers in simultaneously detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and bacterial coinfections and predicting clinical severity of COVID-19. A total of 161 patients with PCR-confirmed COVID-19 (52.2% female; median age, 50.0 years; 51% hospitalized; 5.6% deaths) were enrolled at the Stanford Hospital ED. RNA was extracted (2.5 mL whole blood in PAXgene blood RNA), and 29 host mRNAs in response to the infection were quantified using Nanostring nCounter. The IMX-BVN-3 classifier identified SARS-CoV-2 infection in 151 patients with a sensitivity of 93.8%. Six of 10 patients undetected by the classifier had positive COVID tests more than 9 days prior to enrollment, and the remaining patients oscillated between positive and negative results in subsequent tests. The classifier also predicted that 6 (3.7%) patients had a bacterial coinfection. Clinical adjudication confirmed that 5/6 (83.3%) of the patients had bacterial infections, i.e., Clostridioides difficile colitis (n = 1), urinary tract infection (n = 1), and clinically diagnosed bacterial infections (n = 3), for a specificity of 99.4%. Two of 101 (2.8%) patients in the IMX-SEV-3 "Low" severity classification and 7/60 (11.7%) in the "Moderate" severity classification died within 30 days of enrollment. IMX-BVN-3/IMX-SEV-3 classifiers accurately identified patients with COVID-19 and bacterial coinfections and predicted patients' risk of death. A point-of-care version of these classifiers, under development, could improve ED patient management, including more accurate treatment decisions and optimized resource utilization. IMPORTANCE We assay the utility of the single-test IMX-BVN-3/IMX-SEV-3 classifiers that require just 2.5 mL of patient blood in concurrently detecting viral and bacterial infections as well as predicting the severity and 30-day outcome from the infection. A point-of-care device, in development, will circumvent the need for blood culturing and drastically reduce the time needed to detect an infection. This will negate the need for empirical use of broad-spectrum antibiotics and allow for antibiotic use stewardship. Additionally, accurate classification of the severity of infection and the prediction of 30-day severe outcomes will allow for appropriate allocation of hospital resources