The Role of the Mediterranean Diet in the Prevention of Deep Vein Thrombosis

Since anticoagulation performed by affecting hematological parameters has serious complications such as bleeding, studies are also conducted to benefit from diets instead of prophylactic anticoagulants in order to reduce the risk of developing venous thromboembolism (VTE). Our aim is to review the benefits of the Mediterranean diet in the prophylaxis and treatment of deep vein thrombosis (DVT), although the current studies have yet to be conclusive. The Mediterranean diet is characterized by the consumption of plant-based foods such as vegetables, fruits, nuts, legumes and unprocessed cereals, and seafood such as fish. The consumption of meat and meat products is low in this diet. The consumption of dairy products is also low. Fruits, vegetables and juices in the Mediterranean diet contain a significant amount of flavonoids. In addition, olive oil, which is one of the basic elements of the Mediterranean diet, has antioxidant properties due to its essential polyphenolic compounds. It has been reported that the low consumption of vegetables contributes to the increase of VTE incidence in Thai society. On the contrary, a diet with plenty of herbal food, fish and a small amount of red meat (Mediterranean diet) has been reported to reduce the risk of VTE. We think that the Mediterranean diet, which is beneficial for our health, may also decrease the risk of DVT. However, medical therapy is required for the treatment of patients with DVT. Nutritional approaches, including the Mediterranean diet, should be considered as supplement

Abdülmecid Han Fountain and Cistern and the Inscription of the Halid Ağa Fountain, Unearthed in Haydarpasha

1839 yılında Sultan Abdülmecid’in ihya ettiği Halid Ağa Çeşmesi’nin adı değiştirilerek Abdülmecid Han Çeşmesi olmuştur. 1902 senesinde günümüzdeki Haydarpaşa’daki yerine taşınmış ve çeşme zamanla yol kotu altında kalmıştır. Haydarpaşa Tren İstasyonu alanında, “Marmaray Projesi Gebze-Halkalı Banliyö Hattı İyileştirmesi” kapsamında, İstanbul Arkeoloji Müzeleri denetiminde 2018 senesinde “Haydarpaşa Garı Arkeolojik Kazıları” başlatılmıştır. Kazı çalışmaları sırasında çeşmenin taşınmadan evvelki yerinden Halid Ağa Çeşmesi Kitâbesi bulunmuştur. Tıbbiye Köprüsü G1 ayağının inşası sırasında ise Haydarpaşa’daki mevcut yerinden Abdülmecid Han Çeşmesi ve Sarnıcı ortaya çıkarılmıştır. Tüm bu çalışmalar sayesinde gün ışığına çıkarılan bu eserler kültürel bir miras olarak kentsel dokuya tekrar kazandırılmıştır. Bu çalışmanın literatüre katkısı, çeşmenin yapım tarihinden günümüze kadar geçirdiği tüm değişimlerin belge ve haritalarla tespit edilmesidir. Çeşme, çağdaş örnekleri ile süsleme detayları açısından karşılaştırılmış, ölçü ve yapısal özellikleri tanımlanarak araştırmacılara veri oluşturmuştur. Zamanla işlevini kaybeden çeşmenin yeniden ortaya çıkarılması ile koruma sorunları değerlendirilmiştir.In 1839, the name of the Halid Ağa Fountain, which was restored by Sultan Abdülmecid, was changed into Abdülmecid Han Fountain. It was moved to its current location in Haydarpasha in 1902 and over the time the fountain remained below the road level . In the area of Haydarpaşa Train Station, “Haydarpasha Train Station Archaeological Excavations” was started in 2018 under the supervision of Istanbul Archeology Museums, within the scope of “Marmaray Project Gebze-Halkalı Suburban Line Improvement”. During the excavations, the Halid Ağa Fountain Inscription was found in the place before the fountain was moved. During the construction of the Tıbbiye Bridge G1 pillar, Abdülmecid Han Fountain and Cistern were unearthed from its current location in Haydarpaşa. Thanks to all these works, which were brought to light, were brought back to the urban fabric as a cultural heritage. The contribution of this study to the literature is to identify all the changes that the fountain has undergone from the date of its construction to the present day, with documents and maps. The fountain was compared with its contemporary examples in terms of ornamental details, its size, and the structural features were defined and data were created for researchers. Conservation problems were evaluated with the re-discovery of the fountain, which lost its function over time

Roles of the Oxidative Stress and ADMA in the Development of Deep Venous Thrombosis

Venous thromboembolism has multifactorial origin and occurs in the context of complex interactions between environmental and genetic predisposing factors. Oxidative stress plays an important role in the physiopathology of venous thrombosis. Current study examined the role of oxidative stress and asymmetric dimethylarginine in the development of DVT with the parameters such as serum malondialdehyde (MDA), glutathione peroxidase (GSH-Px), catalase, ADMA, homocysteine, folic acid, vitamin B6, and vitamin B12 levels. Serum MDA levels were found significantly (P0.05). This study showed that patients with DVT have increased oxidative stress compared with the healthy volunteers whereas there was no significant difference between the groups in terms of serum ADMA levels. Thus serum ADMA levels seemed to be not related with development of DVT

The Frequency of Factor V Leiden in Type 2 Diabetic Patients

INTRODUCTION: Diabetes mellitus, a multifactorial and polygenic disease, is a major health problem worldwide. An increased risk for the development of thromboembolic and atherosclerotic diseases has been reported in diabetic patients with Factor V Leiden (FVL) mutation. Therefore, we think that it is important to detect diabetic patients with genetic polymorphism. The aim of our study was to investigate the frequency of FVL mutation in patients with diabetes mellitus. METHODS: This study included 67 patients with diabetes mellitus. FVL mutation was investigated in all patients. The SNaPshot® multiplex system (Applied Biosystems Inc. Switzerland) was used. The heterozygous and homozygous genotypic distributions and percentages were determined. RESULTS: There were 37 females and 30 males, ranging in age from 32 to 88 years with a mean age of 61.6 +- 11.1 years. There were no patients with homozygous FVL mutation. The heterozygous FVL mutation was detected in eight patients (11.9%). Of these eight patients with FVL mutation, five (62.5%) had hypertension, four (50%) had asymptomatic peripheral artery disease, and one (12.5%) had coronary artery disease. DISCUSSION AND CONCLUSION: Although the frequency of FVL mutation is not high in diabetic patients; thromboprophylaxis should be performed in diabetic patients in risky conditions such as surgery, long-term bed rest or trauma