A Comprehensive Review Of The Influence Of Heat Exchange Tubes On Hydrodynamic, Heat, And Mass Transfer In Bubble And Slurry Bubble Columns

Bubble and slurry bubble column reactors (BCRs/SBCRs) are used for various chemical, biochemical, and petrochemical applications. They have several operational and maintenance advantages, including excellent heat and mass transfer rates, simplicity, and low operating and maintenance cost. Typically, a catalyst is present in addition to biochemical processes where microorganisms are used to produce industrially valuable bio-products. Since most applications involve complicated gas-liquid, gas-liquid-solid, and exothermic processes, the BCR/SBCR must be equipped with heat-exchanging tubes to dissipate heat and control the reactor\u27s overall performance. In this review, past and very recent experimental and numerical investigations on such systems are critically discussed. Furthermore, gaps to be filled and critical aspects still requiring investigation are identified

Experimental Investigation on the Impact of Tube Bundle Designs on Heat Transfer Coefficient in Gas-Solid Fluidized Bed Reactor for Fischer-Tropsch Synthesis

The impact of vertical heat exchanging tube bundle on heat transfer coefficient (HTC) has been investigated locally and instantaneously using a sophisticate heat transfer technique using glass beads solid particles of 210 μm average size and 2500 kg/m3 solid density (Geldart B particles), with a static bed height of 0.35 m as bed material. A mimicked Fischer-Tropsch fluidized bed with vertical heat exchanging tubes is designed and built in this study. Heat transfer performance is also investigated by using two different tubes arrangement (square-pitch and triangular-pitch tubes arrangement). To represent the heat exchanging tubes used in the Fischer–Tropsch process, stainless-steel heat exchanging tubes inserted vertically, each with a diameter of 0.012 m, were used in each tubes arrangement occupying 25% of the column cross-section area. The experiments were performed in a 0.13 m inner diameter Plexiglas fluidized bed reactor with varied gas flowrates (0.2–0.48) m/s at numerous radial positions along the diameter of the column (±0.58, ±0.33, and ± 0.03) and two axial locations (H/D = 1.153 and 1.923). It was found that HTCs significantly enhance with increasing the gas flowrates for all radial positions for square-pitch tubes arrangement. While different behavior can be noticed in the radial positions with triangular-pitch tube arrangement, especially near the wall region (±0.33). Also, the local heat transfer coefficient (LHTC) improved with increasing the axial positions by 12.06% at highest gas flowrates (0.48 m/s). Moreover, the square-pitch tubes arrangement showed a significant increase and uniformity in HTC when measured instantaneously comparing with other tubes arrangement. Furthermore, the findings of this study will improve awareness of vertical tubes\u27 effect on heat transfer in a fluidized bed reactor. Moreover, the data acquired from this investigation can be employed to validate reactor models, CFD codes, and simulations in order to support the design and scale-up processes of such reactors

Experimental Investigation on the Impact of Tube Bundle Designs on Heat Transfer Coefficient in Gas-Solid Fluidized Bed Reactor for Fischer-Tropsch Synthesis

The impact of vertical heat exchanging tube bundle on heat transfer coefficient (HTC) has been investigated locally and instantaneously using a sophisticate heat transfer technique using glass beads solid particles of 210 μm average size and 2500 kg/m3 solid density (Geldart B particles), with a static bed height of 0.35 m as bed material. A mimicked Fischer-Tropsch fluidized bed with vertical heat exchanging tubes is designed and built in this study. Heat transfer performance is also investigated by using two different tubes arrangement (square-pitch and triangular-pitch tubes arrangement). To represent the heat exchanging tubes used in the Fischer-Tropsch process, stainless-steel heat exchanging tubes inserted vertically, each with a diameter of 0.012 m, were used in each tubes arrangement occupying 25% of the column cross-section area. The experiments were performed in a 0.13 m inner diameter Plexiglas fluidized bed reactor with varied gas flowrates (0.2-0.48) m/s at numerous radial positions along the diameter of the column (±0.58, ±0.33, and ± 0.03) and two axial locations (H/D = 1.153 and 1.923). It was found that HTCs significantly enhance with increasing the gas flowrates for all radial positions for square-pitch tubes arrangement. While different behavior can be noticed in the radial positions with triangular-pitch tube arrangement, especially near the wall region (±0.33). Also, the local heat transfer coefficient (LHTC) improved with increasing the axial positions by 12.06% at highest gas flowrates (0.48 m/s). Moreover, the square-pitch tubes arrangement showed a significant increase and uniformity in HTC when measured instantaneously comparing with other tubes arrangement. Furthermore, the findings of this study will improve awareness of vertical tubes\u27 effect on heat transfer in a fluidized bed reactor. Moreover, the data acquired from this investigation can be employed to validate reactor models, CFD codes, and simulations in order to support the design and scale-up processes of such reactors

Experimental Investigation and Computational Fluid Dynamic Simulation of Hydrodynamics of Liquid–Solid Fluidized Beds

The present study provides and examines an experimental and CFD simulation to predict and accurately quantify the individual phase holdup. The experimental findings demonstrated that the increase of solid beads has a significant influence on the (Umf), as comparatively small glass beads particles require a low (Umf) value, which tends to increase as the diameter of the beads increases. Besides that, the expansion ratio is proportional to the velocity of the liquid. Even though, the relationship becomes inversely proportional to the diameter of the beads. The liquid holdup was found to increase with increasing liquid velocity, however, the solid holdup decreased. The Eulerian–Eulerian granular multiphase flow technique was used to predict the overall performance of the liquid–solid fluidized beds (LSFBs). There was a good agreement between the experimental results and the dynamic properties of liquid–solid flows obtained from the CFD simulation, which will facilitate future simulation studies of liquid–solid fluidized beds. This work has further improved the understanding and knowledge of CFD simulation of such a system at different parameters. Furthermore, understanding the hydrodynamics features within the two-phase fluidization bed, as well as knowing the specific features, is essential for good system design, enabling the systems to perform more effectively

Experimental Investigation and Computational Fluid Dynamic Simulation of Hydrodynamics of Liquid–Solid Fluidized Beds

The present study provides and examines an experimental and CFD simulation to predict and accurately quantify the individual phase holdup. The experimental findings demonstrated that the increase of solid beads has a significant influence on the (Umf), as comparatively small glass beads particles require a low (Umf) value, which tends to increase as the diameter of the beads increases. Besides that, the expansion ratio is proportional to the velocity of the liquid. Even though, the relationship becomes inversely proportional to the diameter of the beads. The liquid holdup was found to increase with increasing liquid velocity, however, the solid holdup decreased. The Eulerian–Eulerian granular multiphase flow technique was used to predict the overall performance of the liquid–solid fluidized beds (LSFBs). There was a good agreement between the experimental results and the dynamic properties of liquid–solid flows obtained from the CFD simulation, which will facilitate future simulation studies of liquid–solid fluidized beds. This work has further improved the understanding and knowledge of CFD simulation of such a system at different parameters. Furthermore, understanding the hydrodynamics features within the two-phase fluidization bed, as well as knowing the specific features, is essential for good system design, enabling the systems to perform more effectively

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research