57 research outputs found
Hydrolysis of histones by proteinases
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Full text linkNew insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
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- Alarcón-Martín Emilio
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- Sakka P.
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- Salomaa V.
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- Sarnowski C.
- Sastre I.
- Satizabal C.L.
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- Schutzman J.
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- Seeley W.W.
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- Serpi R.
- Serrano M.
- Seshadri S.
- Sevillano Z.
- Sha J.
- Shadrin A.A.
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- Shaw C.E.
- Shcherban A.
- Shin J.
- Shofany J.
- Shulman J.M.
- Siirtola H.
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- Sims Rebecca
- Sinisalo J.
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- Siponen M.
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- Sleegers K.
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- Sliz E.
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- Smaoui N.
- Smith A.D.
- Smith A.G.
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- Smith J.P.
- Snijders G.J.L.
- Soininen H.
- Solfrizzi V.
- Solis P.
- Solomon A.
- Song Y.E.
- Song Y.E.
- Sonnen J.A.
- Sorbi S.
- Sotolongo Grau Oscar
- Spallazzi M.
- Spalletta G.
- Spina S.
- Spottke A.
- Squassina A.
- Stern R.A.
- Stevens A.B.
- Stordal E.
- Strandberg T.
- Strauss E.
- Strittmatter S.M.
- Ståhlbom A.K.
- Sultzer D.
- Suominen L.
- Sussams R.
- Swerdlow R.H.
- Sáez María Eugenia
- Sánchez-Arjona M.B.
- Sánchez-Valle R.
- Takalo M.
- Tanzi R.E.
- Tartan J.P.
- Tasanen K.
- Taskinen M.R.
- Teipel S.
- Teng E.
- Tesí N.
- Teumer A.
- Thalamuthu A.
- Thomas A.
- Thomas C.
- Thomas T.
- Thomassen J.Q.
- Thonberg H.
- Tienari P.
- Tilson J.L.
- Tin A.
- Todd S.
- Toso C.R.
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- Traykov L.
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- Trojanowski J.Q.
- Troncoso J.C.
- Tsai E.
- Tsolaki A.
- Tsolaki M.
- Tsuang D.W.
- Tsuo K.
- Tucker-Drob E.
- Tukiainen T.
- Tuomi T.
- Tuomilehto J.
- Tuovila O.
- Turpeinen M.
- Turton J.
- Turunen J.A.
- Tybjærg-Hansen A.
- Tzourio C.
- Tárraga L.
- Uitterlinden A.
- Ullgren A.
- Ulstein I.
- Universitat Autònoma de Barcelona
- Uphill J.
- Usiskin K.
- Uusitalo H.
- Uusitalo-Järvinen H.
- Vacca A.
- Vainio S.
- Valero S.
- Valladares O.
- Valladares O.
- van Adelsberg J.
- Van Deerlin V.M.
- van den Bussche H.
- van der Flier Wiesje M
- van der Lee S.J.
- van der Lugt A.
- van Duijn C.M.
- van Eldik L.J.
- van Lent D.M.
- van Rooij J.
- van Swieten J.
- Vance J.
- Vandenberghe R.
- Vardarajan B.N.
- Vardy E.
- Vargas L.
- Vassar R.
- Verhey F.
- Vicente M. P.
- Vidal J.S.
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vilas R.H.
- Vinters H.V.
- Virolainen P.
- Vivancos L.
- Vogelgsang J.
- Vojinovic D.
- Vonsattel J.P.
- Voutilainen M.
- Vyhnalek M.
- Wadhawan S.
- Wagner M.
- Wallon D.
- Wang C.
- Wang L.S.
- Wang R.
- Wang Y.
- Warden D.
- Waring J.
- Waring J.
- Warner N.
- Warren J.D.
- Waterworth D.
- Weber H.
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K.A.
- Whelan C.
- Whitehead P.L.
- Wichmann H.E.
- Wigmore E.
- Wijsman E.M.
- Wilcock G.
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- Wong R.
- Woods B.
- Woon M.
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- Wu C.K.
- Wu Y.
- Xia T.h.
- Xu E.
- Xu F.
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Younkin S.G.
- Yu C.E.
- Yu L.
- Zare H.
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C.P.
- Zompo M.D.
- Zulaica M.
- Álvarez V.
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- Publication date
- 01/01/2022
- Field of study
Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- Author
- Aaltonen L
- Aaltonen V
- Arvas M
- Auge F
- Auranen A
- Auro K
- Auvinen P
- Awaisa G
- Betts J
- Bhangale T
- Bing N
- Biswas S
- Blomster T
- Bowers N
- Brein G
- Bronson P
- Call K
- Carpen O
- Challis B
- Chang D
- Chatelain C
- Chen CY
- Chen H
- Chen X
- Chhibber A
- Chu A
- Close D
- Crohns M
- Dada A
- Daly MJ
- Davis JW
- Diogo D
- Donner K
- Eaton S
- Ehm M
- Eicher J
- Eklund K
- Elenius K
- Esmaeeli S
- Farkkila M
- Fox C
- Freimer NB
- Ganna A
- Georgantas B
- Gerl MJ
- Ghosh S
- Gordillo JE
- Gormley P
- Gossel M
- Greenberg S
- Hannula-Jouppi K
- Harju J
- Harju T
- Harvima I
- Hassan S
- Hautala N
- Havulinna AS
- Heap G
- Hedman A
- Heikkinen S
- Hendolin M
- Hiekkalinna T
- Hiltunen M
- Hinttala R
- Hochfeld M
- Hoffman J
- Holzinger E
- Hu XL
- Huhtakangas J
- Huilaja L
- Hunkapiller J
- Hyvarinen K
- Isomaki P
- Jacob H
- Jalanko A
- Jarvensivu E
- Jauhiainen M
- Jimenez MG
- Joensuu H
- John S
- Julkunen V
- Junttila J
- Juonala M
- Jussila A
- Kaarniranta K
- Kaarteenaho R
- Kahonen M
- Kaiharju E
- Kaipiainen-Seppanen O
- Kajanne R
- Kalaoja M
- Kallio L
- Kalpala K
- Kalviainen R
- Kangasniemi E
- Kankaanranta H
- Kaprio J
- Karihtala P
- Karjalainen J
- Karjalainen M
- Karlsson A
- Kaunisto M
- Kauppi P
- Kauppila S
- Kerchner G
- Kettunen J
- Kiiskinen TTJ
- Kilpelainen E
- Kilpi T
- Kiviniemi M
- Klinger K
- Klose C
- Kononen J
- Koskela JT
- Koskinen M
- Kosma VM
- Koulu L
- Kristiansson K
- Kujala U
- Kulkarni D
- Kuopio T
- Kurki M
- Laakkonen E
- Laakso M
- Laaksonen R
- Lahteenmaki S
- Laiho P
- Laitinen T
- Laivuori H
- Landenpera S
- Laukkanen J
- Laukkanen M
- Lehisto A
- Lehtonen A
- Lehtonen H
- Lemmela S
- Lertratanakul A
- Linden K
- Liu J
- Llorens V
- Loboda A
- Loukola A
- Lu T
- Luodonpaa M
- Lyhs U
- Makela T
- Malarstig A
- Mannermaa A
- Mannikko L
- Mantere T
- Maranville J
- Mars N
- Marshal C
- Matakidou A
- Matikainen N
- Mattsson H
- McCarthy L
- McCarthy M
- McDonough S
- Mehta V
- Meretoja T
- Metsarinne K
- Michon J
- Miller M
- Muslin A
- Niiranen T
- Nunez-Fontarnau J
- Oh D
- Ollila T
- Pakkanen R
- Palin K
- Palomaki A
- Paloneva J
- Palotie A
- Palta P
- Parkkinen J
- Parolo PD
- Parr K
- Partanen J
- Pelkonen M
- Peltola J
- Peltonen S
- Perola M
- Peterson A
- Petrovski S
- Pihlajamaki J
- Pikkarainen S
- Pirila L
- Pirinen M
- Pitkanen K
- Pitkaranta A
- Plenge R
- Podgornaia A
- Popovic R
- Pulford D
- Pulkki K
- Pylkas K
- Quarless D
- Rahimov F
- Ramo JT
- Remes A
- Riley-Gillis B
- Rinne J
- Ripatti P
- Ripatti S
- Ritari J
- Rivas M
- Runz H
- Salmi T
- Salomaa V
- Savinainen K
- Schleutker J
- Schutzman J
- Seitsonen S
- Service SK
- Shcherban A
- Siirtola H
- Simons K
- Sinisalo J
- Sipila T
- Sipila TP
- Sistonen T
- Smaoui N
- Soderlund S
- Soini S
- Soininen H
- Stitziel NO
- Strauss E
- Surma MA
- Tabassum R
- Tabuenca JG
- Tasanen K
- Taskinen MR
- Teng E
- Tienari P
- Tuomi T
- Tuovila O
- Turunen J
- Usiskin K
- Uusitalo H
- Uusitalo-Jarvinen H
- Vainio S
- Virolainen P
- Voutilainen M
- Wahlfors T
- Wang C
- Wang XL
- Waring J
- Waterworth D
- Whelan C
- Wong R
- Wu Y
- Xu E
- Xu FL
- Yang R
- Zhou W
- Ziemann A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/10/2022
- Field of study
Get PDFUnderstanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 x10(-8)), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD
Pharmacological treatment options for mast cell activation disease
- Author
- A Akhavein
- A Baba
- A Böhm
- A Clemons
- A Dueñas-Laita
- A Frenkel
- A Hochhaus
- A Lundequist
- A Paivandy
- A Pardanani
- A Pardanani
- A Pardanani
- A Quintás-Cardama
- A Quintás-Cardama
- A Spyridonidis
- A Tanaka
- A Tanimoto
- A Tefferi
- A Vega-Ruiz
- A Yacoub
- AD Lock
- AF Hagel
- AI Mallet
- AM Edwards
- AM Edwards
- AS Corbin
- AS Worobec
- AW Hauswirth
- B Gruson
- B Haenisch
- B Haenisch
- B Hennessy
- B Jin
- B Peter
- B Peter
- B Sido
- B Vrugt
- BD McNeil
- BF Gibbs
- BM Jensen
- Britta Haenisch
- BS Friedman
- BV Kettelhut
- C Akin
- C Papayannidis
- C Paul
- C Sandler
- C Tang
- C Ustun
- C Yoshida
- CS Johnston
- D Filippis De
- D Kempuraj
- D Purtill
- DF Finn
- DL Marquardt
- DS El-Agamy
- E Cikler
- E Hadzijusufovic
- E Jones
- E Oppong
- EA Welch
- F Siebenhaar
- Franz Ludwig Dumoulin
- G Damaj
- G Fumo
- G Gri
- G Mattace Raso
- G Topar
- Gerhard J. Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GJ Molderings
- GS Papaetis
- H Broyd
- H Nolte
- H Rosen
- H Zachariae
- HC Kluin-Nelemans
- HC Kluin-Nelemans
- HJ Droogendijk
- I Bachelet
- I Kaneko
- I Marech
- I Marton
- I Ruano
- IB Chatterjee
- IJ Chan
- IM Otani
- IT Harvima
- J Aman
- J Gotlib
- J Pan
- J Simon
- J Spirkoski
- J Tolar
- JA Boyce
- JA Gurgel
- JC Cardet
- Jens Panse
- JH Butterfield
- JH Butterfield
- JH Butterfield
- JH Butterfield
- JH Butterfield
- JJ Doormaal van
- JJ Doormaal van
- JM Rodrigues
- Joseph Butterfield
- JR Biesiekierski
- Jürgen Homann
- K Cooper
- K Hoffmann
- K Kontou-Fili
- K Uchida
- K Vaali
- K Weller
- K Yamaki
- KH Lim
- KJ Aichberger
- KV Gleixner
- KV Gleixner
- L Escribano
- L Facci
- L Kibsgaard
- L Pagano
- L Rodrigo
- L Sagi
- Lawrence B. Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LB Afrin
- LJ Kay
- M Bidri
- M Frieri
- M Karlberg
- M Karlberg
- M Kohno
- M Kurosawa
- M Laroche
- M Maurer
- M Mousli
- M Picard
- M Radojković
- M Ritter
- M Tachibana
- M Zen
- MA Nader
- Markus Menzen
- MC Bell
- MC Carter
- MC Heinrich
- MD Estévez
- MG Alexandrakis
- MH Bae
- MJ Hamilton
- MK Church
- MT Krauth
- MT Krauth
- N Eskandari
- N Katoh
- N Randall
- NA Soter
- O Correia
- O Hantschel
- O Hermine
- OS Baek
- P Anand
- P Casassus
- P Erben
- P Giraldo Castellano
- P Kempna
- P Paez
- P Strati
- P Valent
- P Valent
- P Valent
- P Valent
- PD Moon
- PJ Koelink
- PJ Turner
- PR Evora
- R Joks
- R Nakamura
- R Seifert
- RF Horan
- RG Breslow
- S Adachi
- S Aldi
- S Babaei
- S Barete
- S Bibi
- S Broesby-Olsen
- S Dix
- S Knapper
- S Lechowski
- S Lieberoth
- S Matsubara
- S Verstovsek
- S Yamaguchi
- SA Parikh
- SJ Galli
- SM Duffy
- SM Meeran
- SR Kinney
- SS Cohen
- Stefan Brettner
- T Fujimoto
- T Gromke
- T Lasho
- T Mühlenberg
- T Rodriguez
- T Shimoda
- T Suzuki-Nishimura
- TD Trojan
- TH Park
- TY Lin
- TY Lin
- U Krug
- UB Nurmatov
- UW Laengle
- VR Simhadri
- Y Hagenlocher
- Y Yang
- YD Min
- YS Lee
- Z Ma
- Z Weng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Get PDFSeparation and partial characterization of proteinases with substrate specificity for basic amino acids from human MOLT-4 T lymphocytes: identification of those inhibited by variable-loop-V3 peptides of HIV-1 (human immunodeficiency virus-1) envelope glycoprotein
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
No full textHistamine and leukotriene C4 release in cutaneous mosquito-bite reactions
- Publication venue
- Publication date
- 01/01/1996
- Field of study
No full textAlterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textBiochemical and histochemical evaluation of tryptase in various human tissues
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text- …
