Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Objectives: Osteoporosis is commonly developed due tonatural course of Behçet’s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-α (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The study included two groupsas the study and the control group. Serum levels of TNF-α,osteoprotegerin, osteocalcine, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), and urinary creatinine anddeoxypyridinoline along with BMD level were evaluated andcompared. Correlation between TNF-α and osteoprotegerinlevel was investigated.Results: The study enrolled 41 BD patients and 36 agedmatchedcontrol subjects. Mean age was 42.26±11.64 and41.66±70.99, in the study and control groups, respectively.There was no significant difference in body mass index(BMI) of subjects between groups (p>0.05). Level of TNF-α(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine(p=0.041) was significantly higher in the study group comparedto the control group. Osteoprotegerin was lower inBD patients, but the difference was not significant (p>0.05).Urinary deoxypyridinoline/ urinary creatinine ratio in patientswith BD was significantly higher than those in control group(p=0.030). Patients had significantly lower BMD comparfedto the control group, except L2-L4 vertebral area (p<0.001,p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 andp=0.111, respectively). No correlation was found betweenTNF-α and osteoprotegerin.Conclusions: The present study indicated that TNF-α andBMD was negatively correlated with each other and TNF-αhad an effect on osteoporotic process in patients with BD.Osteoprotegerin level was not decreased, and not correlatedwith TNF-α.Key words: Behçet’s disease, osteoprotegerin, TNF-α, osteocalcin

Behçet hastalarında serum TNF- ? ve osteoprotegerin düzeyi ve kemik kitle yoğunluğu

Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-?) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-?, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.2611.64 ve 41.6670.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-? (p0.001), deokspiridinolin (p0.001) ve osteokalsin (p0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p0.03). Hasta grubun KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı oranda düşüktü (sırasıyla p0.001, p0.001, p0.035, p0.001, p0.012, p0.001, p0.001 ve p0.111). TNF-? ve osteoprotegerin arasında korelasyon saptanmadı. Sonuç: Bu çalışmada TNF-? ve KMD arasında negatif korelasyon saptandı ve TNF-?’nın, BH’da osteoporotik süreci etkilediği bulundu. Osteoprotogerin düzeyi düşüklüğü anlamlı değildi ve TNF-? ile korele değildi.Objectives: Osteoporosis is commonly developed due to natural course of Behçet&#8217;s disease (BD) and therapeutic agents. It was aimed to investigate levels of osteoprotegerin and TNF-&#945; (tumor necrosis factor), and bone mineral density (BMD) and correlation between them in BD. Materials and methods: The study included two groups as the study and the control group. Serum levels of TNF-&#945;, osteoprotegerin, osteocalcine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinary creatinine and deoxypyridinoline along with BMD level were evaluated and compared. Correlation between TNF-&#945; and osteoprotegerin level was investigated. Results: The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and 41.66±70.99, in the study and control groups, respectively. There was no significant difference in body mass index (BMI) of subjects between groups (p>0.05). Level of TNF-&#945; (p0.05). Urinary deoxypyridinoline/ urinary creatinine ratio in patients with BD was significantly higher than those in control group (p0.030). Patients had significantly lower BMD comparfed to the control group, except L2-L4 vertebral area (p<0.001, p<0.001, p0.035, p<0.001, p0.012, p<0.001, p<0.001 and p0.111, respectively). No correlation was found between TNF-&#945; and osteoprotegerin. Conclusions: The present study indicated that TNF-&#945; and BMD was negatively correlated with each other and TNF-&#945; had an effect on osteoporotic process in patients with BD. Osteoprotegerin level was not decreased, and not correlated with TNF-&#945;