Studying Group Decision Making in Affinity Diagramming

Affinity diagramming is a commonly used contextual design practice for which many tools have been developed. However, experts and novices alike eschew tool use, instead using traditional paper and whiteboard methods. This paper presents observations of traditional affinity diagramming sessions, focusing on three areas of consideration—shared awareness, cognitive offloading, and understanding, organizing and searching—that are important for collaborative tools. Specific design requirements for each of these three areas are described

Elucidation of the Hsp90 C-terminal Inhibitor Binding Site

The Hsp90 chaperone machine is required for the folding, activation and/or stabilization of more than 50 proteins directly related to malignant progression. Hsp90 contains small molecule binding sites at both its N- and C-terminal domains, however, limited structural and biochemical data regarding the C-terminal binding site is available. In this report, the small molecule binding site in the Hsp90 C-terminal domain was revealed by protease fingerprinting and photoaffinity labeling utilizing LC-MS/MS. The identified site was characterized by generation of a homology model for hHsp90α using the SAXS open structure of HtpG and docking the bioactive conformation of NB into the generated model. The resulting model for the bioactive conformation of NB bound to Hsp90α is presented herein

Physigrams: Modelling Devices for Natural Interaction

This paper explores the formal specification of the physical behaviour of devices 'unplugged'; from their digital effects. By doing this we seek to better understand the nature of physical interaction and the way this can be exploited to improve the design of hybrid devices with both physical and digital features. We use modified state transition networks of the physical behaviour, which we call physigrams, and link these to parallel diagrams of the digital state. These are used to describe a number of features of physical interaction exposed by previous work and relevant properties expressed using a formal semantics of the diagrams. As well as being an analytic tool, the physigrams have been used in a case study where product designers used and adapted them as part of the design process