New Oleoyl Hybrids of Natural Antioxidants: Synthesis and In Vitro Evaluation as Inducers of Apoptosis in Colorectal Cancer Cells

Nowadays, the beneficial role of a healthy lifestyle, particularly emphasizing the quality of foods and cancer management, is accepted worldwide. Polyphenols and oleic acid play a key role in this context, but are still scarcely used as anti-cancer agents due to their bio-accessibility limits. Therefore, we aimed to synthesize a set of new oleoyl-hybrids of quercetin, morin, pinocembrin, and catechin to overcome the low bioavailability of polyphenols, throughout a bio-catalytic approach using pancreatic porcine lipase as a catalyst. The in vitro assays, using a wide panel of human cancer cell lines showed, mainly for two novel regioisomer oleoyl-hybrids of quercetin, a remarkable increase in apoptotic cell populations. We suggested that the DNA damage shown as ɣH2AX signals might be the major cause of apoptotic cell death. Finally, we demonstrated convincing data about two novel polyphenol-based hybrids displaying a highly selective anti-cancer cytotoxicity and being superior compared to their reference/parental compounds

A CTP-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels

SummaryProteins of the cradle-loop barrel metafold are formed by duplication of a conserved βαβ-element, suggesting a common evolutionary origin from an ancestral group of nucleic acid-binding proteins. The basal fold within this metafold, the RIFT barrel, is also found in a wide range of enzymes, whose homologous relationship with the nucleic acid-binding group is unclear. We have characterized a protein family that is intermediate in sequence and structure between the basal group of cradle-loop barrels and one family of RIFT-barrel enzymes, the riboflavin kinases. We report the structure, substrate-binding mode, and catalytic activity for one of these proteins, Methanocaldococcus jannaschii Mj0056, which is an archaeal riboflavin kinase. Mj0056 is unusual in utilizing CTP rather than ATP as the donor nucleotide, and sequence conservation in the relevant residues suggests that this is a general feature of archaeal riboflavin kinases

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement

Agree to Agree: Agreement in the Minimalist Programme

Agreement is a pervasive phenomenon across natural languages. Depending on one’s definition of what constitutes agreement, it is either found in virtually every natural language that we know of, or it is at least found in a great many. Either way, it seems to be a core part of the system that underpins our syntactic  knowledge. Since the introduction of the operation of Agree in Chomsky (2000), agreement phenomena and the mechanism that underlies agreement have garnered a lot of attention in the Minimalist literature and have received different theoretical treatments at different stages. Since then, many different phenomena  involving dependencies between elements in syntax, including movement or not, have been accounted for using Agree. The mechanism of Agree thus provides a powerful tool to model dependencies between syntactic elements far beyond φ-feature agreement. The articles collected in this volume further explore these topics  and contribute to the ongoing debates surrounding agreement. The authors gathered in this book are internationally reknown experts in the field of Agreement