General-Relativistic Curvature of Pulsar Vortex Structure

The motion of a neutron superfluid condensate in a pulsar is studied. Several theorems of general-relativistic hydrodynamics are proved for a superfluid. The average density distribution of vortex lines in pulsars and their general-relativistic curvature are derived.Comment: 18 pages, 1 figure

Replica symmetry breaking in an adiabatic spin-glass model of adaptive evolution

We study evolutionary canalization using a spin-glass model with replica theory, where spins and their interactions are dynamic variables whose configurations correspond to phenotypes and genotypes, respectively. The spins are updated under temperature T_S, and the genotypes evolve under temperature T_J, according to the evolutionary fitness. It is found that adaptation occurs at T_S < T_S^{RS}, and a replica symmetric phase emerges at T_S^{RSB} < T_S < T_S^{RS}. The replica symmetric phase implies canalization, and replica symmetry breaking at lower temperatures indicates loss of robustness.Comment: 5pages, 2 figure

Error threshold in the evolution of diploid organisms

The effects of error propagation in the reproduction of diploid organisms are studied within the populational genetics framework of the quasispecies model. The dependence of the error threshold on the dominance parameter is fully investigated. In particular, it is shown that dominance can protect the wild-type alleles from the error catastrophe. The analysis is restricted to a diploid analogue of the single-peaked landscape.Comment: 9 pages, 4 Postscript figures. Submitted to J. Phy. A: Mat. and Ge

Orbital evolution of a particle around a black hole: II. Comparison of contributions of spin-orbit coupling and the self force

We consider the evolution of the orbit of a spinning compact object in a quasi-circular, planar orbit around a Schwarzschild black hole in the extreme mass ratio limit. We compare the contributions to the orbital evolution of both spin-orbit coupling and the local self force. Making assumptions on the behavior of the forces, we suggest that the decay of the orbit is dominated by radiation reaction, and that the conservative effect is typically dominated by the spin force. We propose that a reasonable approximation for the gravitational waveform can be obtained by ignoring the local self force, for adjusted values of the parameters of the system. We argue that this approximation will only introduce small errors in the astronomical determination of these parameters.Comment: 11 pages, 7 figure

Genetic evidence that the Makira region in northeastern Madagascar is a hotspot of malaria transmission

Additional file 3: Figure S1. Contains the bootstrap re-sample statistics for comparing genetic relatedness

Bose-Einstein distribution, condensation transition and multiple stationary states in multiloci evolution of diploid population

The mapping between genotype and phenotype is encoded in the complex web of epistatic interaction between genetic loci. In this rugged fitness landscape, recombination processes, which tend to increase variation in the population, compete with selection processes that tend to reduce genetic variation. Here we show that the Bose-Einstein distribution describe the multiple stationary states of a diploid population under this multi-loci evolutionary dynamics. Moreover, the evolutionary process might undergo an interesting condensation phase transition in the universality class of a Bose-Einstein condensation when a finite fraction of pairs of linked loci, is fixed into given allelic states. Below this phase transition the genetic variation within a species is significantly reduced and only maintained by the remaining polymorphic loci.Comment: (12 pages, 7 figures

Fokker-Planck and Landau-Lifshitz-Bloch Equations for Classical Ferromagnets

A macroscopic equation of motion for the magnetization of a ferromagnet at elevated temperatures should contain both transverse and longitudinal relaxation terms and interpolate between Landau-Lifshitz equation at low temperatures and the Bloch equation at high temperatures. It is shown that for the classical model where spin-bath interactions are described by stochastic Langevin fields and spin-spin interactions are treated within the mean-field approximation (MFA), such a ``Landau-Lifshitz-Bloch'' (LLB) equation can be derived exactly from the Fokker-Planck equation, if the external conditions change slowly enough. For weakly anisotropic ferromagnets within the MFA the LLB equation can be written in a macroscopic form based on the free-energy functional interpolating between the Landau free energy near T_C and the ``micromagnetic'' free energy, which neglects changes of the magnetization magnitude |{\bf M}|, at low temperatures.Comment: 9 pages, no figures, a small error correcte

Genome-Wide Gene Expression Effects of Sex Chromosome Imprinting in Drosophila

Imprinting is well-documented in both plant and animal species. In Drosophila, the Y chromosome is differently modified when transmitted through the male and female germlines. Here, we report genome-wide gene expression effects resulting from reversed parent-of-origin of the X and Y chromosomes. We found that hundreds of genes are differentially expressed between adult male Drosophila melanogaster that differ in the maternal and paternal origin of the sex chromosomes. Many of the differentially regulated genes are expressed specifically in testis and midgut cells, suggesting that sex chromosome imprinting might globally impact gene expression in these tissues. In contrast, we observed much fewer Y-linked parent-of-origin effects on genome-wide gene expression in females carrying a Y chromosome, indicating that gene expression in females is less sensitive to sex chromosome parent-of-origin. Genes whose expression differs between females inheriting a maternal or paternal Y chromosome also show sex chromosome parent-of-origin effects in males, but the direction of the effects on gene expression (overexpression or underexpression) differ between the sexes. We suggest that passage of sex chromosome chromatin through male meiosis may be required for wild-type function in F1 progeny, whereas disruption of Y-chromosome function through passage in the female germline likely arises because the chromosome is not adapted to the female germline environment

A Population Genetic Approach to the Quasispecies Model

A population genetics formulation of Eigen's molecular quasispecies model is proposed and several simple replication landscapes are investigated analytically. Our results show a remarcable similarity to those obtained with the original kinetics formulation of the quasispecies model. However, due to the simplicity of our approach, the space of the parameters that define the model can be explored. In particular, for the simgle-sharp-peak landscape our analysis yelds some interesting predictions such as the existence of a maximum peak height and a mini- mum molecule length for the onset of the error threshold transition.Comment: 16 pages, 4 Postscript figures. Submited to Phy. Rev.