16 research outputs found
Contemporary Foreign Policy in Historical Perspective
When I received the invitation to address this audience on the subject of Contemporary Foreign Policy, I began to reflect on the episode, in my own experience which I thought might have some relevance to the changes we see occurring in the world today. The first thing that came to mind was a moment back in October of 1939, just after the Germans had overrun Poland. I arrived, a novice in such matters, in the city of Berlin and sought out the advice of the American military attack, a man greatly respected and honored in the American community in Berlin at the time. He was Col. Bullmoose Smith, the recognized brains of the military team in the Embassy at the time. I went in to him and asked, What is it all about
The Berlin Situation
The significant fact is that over the past two or three months of this Berlin crisis, the West has been developing an increasingly strong position from the points of view of politics and propaganda, of economics and cultural influence
The Ursinus Weekly, April 3, 1975
Someone old, someone new • Come to Ursinus: Land of the Pennsylvania Dutch • CCC student success seen • Newman Club • The Birds • Free, but show invitations • Editorial: Visitation - time for reality? • Letter to the editor: Breakage reply • Gymnastics • Record review: For earth below, Robin Trower • Wanted: More Lantern contributors • Spring sports special: 1975! • 1975 Ursinus baseball outlook • 1975 track prospectus • Another season, another title! • A.L. spotlight • Interview: Pat Williams • National League previewhttps://digitalcommons.ursinus.edu/weekly/1033/thumbnail.jp
Solubilization and Humanization of Paraoxonase-1
Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule in the development of a catalytic bioscavenger of OP pesticides and nerve agents. Human PON1 expressed in E. coli is mostly found in the insoluble fraction, which motivated the engineering of soluble variants, such as G2E6, with more than 50 mutations from huPON1. We examined the effect on the solubility, activity, and stability of three sets of mutations designed to solubilize huPON1 with fewer overall changes: deletion of the N-terminal leader, polar mutations in the putative HDL binding site, and selection of the subset of residues that became more polar in going from huPON1 to G2E6. All three sets of mutations increase the solubility of huPON1; the HDL-binding mutant has the largest effect on solubility, but it also decreases the activity and stability the most. Based on the G2E6 polar mutations, we “humanized” an engineered variant of PON1 with high activity against cyclosarin (GF) and found that it was still very active against GF with much greater similarity to the human sequence
The Place of the Armed Forces in the Making of National Strategy
I approach this subject with some hesitation. I\u27ve done a great deal of thinking, myself, about what national strategy should be, but not until I received the invitation to address this group had I ever tried to think through the relationship to each other of the various elements involved in the making of national strategy
Recommended from our members
Joseph C. Harsch, The Meaning of the News; Fulton Lewis, Jr.; Charles Lewis
Side 1 contains Joseph C. Harsch's program, The Meaning of the News, a CBS program, followed by Fulton Lewis, Jr., who broadcast on the Mutual Network. Side 2 contains another program by Fulton Lewis, Jr., and another where Charles Lewis substitutes for Fulton, Lewis, Jr
Electrical and Optical Properties of As-Grown and Electron-Irradiated ZnO
Large-diameter (up to 3-inch), n-type ZnO boules grown by a new vapor-phase transport method were studied by temperature-dependent Hall-effect (TDH) and photoluminescence (PL) measurements. From fits to the TDH data, the dominant donor has a concentration ND of about 1×1017 cm-3 and an energy of about 60 meV, close to the expected hydrogenic value, whereas the total acceptor concentration NA is much lower, about 2×1015cm-3. The 2-K PL data include a series of at least seven sharp lines over the energy range 3.356-3.366 eV, and from polarization, magnetic-field, and annealing (up to 1000°C) experiments, these lines are interpreted as donor-bound excitons associated with donor complexes having different spacings between the atomic species. Electron-irradiation experiments show an electrical and optical threshold, attributed to Zn displacements, at an electron bombardment energy of about 1.3 MeV. The irradiation creates acceptors and destroys shallow donors, but these effects are produced at much lower rates than those found in most other common semiconductor materials, such as Si, GaAs, and GaN
Electrical and Optical Properties of As-Grown and Electron-Irradiated ZnO
Large-diameter (up to 3-inch), n-type ZnO boules grown by a new vapor-phase transport method were studied by temperature-dependent Hall-effect (TDH) and photoluminescence (PL) measurements. From fits to the TDH data, the dominant donor has a concentration ND of about 1×1017 cm-3 and an energy of about 60 meV, close to the expected hydrogenic value, whereas the total acceptor concentration NA is much lower, about 2×1015cm-3. The 2-K PL data include a series of at least seven sharp lines over the energy range 3.356-3.366 eV, and from polarization, magnetic-field, and annealing (up to 1000°C) experiments, these lines are interpreted as donor-bound excitons associated with donor complexes having different spacings between the atomic species. Electron-irradiation experiments show an electrical and optical threshold, attributed to Zn displacements, at an electron bombardment energy of about 1.3 MeV. The irradiation creates acceptors and destroys shallow donors, but these effects are produced at much lower rates than those found in most other common semiconductor materials, such as Si, GaAs, and GaN