Association between dietary acrylamide intake and the risk of multiple myeloma, diffuse large cell lymphoma, and chronic lymphocytic leukemia according to sex and smoking status; the Netherlands Cohort Study on diet and cancer, 1986–2002.¹

1<p>HR  =  hazard ratio; CI  =  Confidence Interval; py  =  person years; Q  =  quintile; T  =  tertile. The number of cases and person-years are the numbers that resulted after listwise deletion of observations with missing values for the selected confounders. HRs were calculated by using Cox proportional hazards analysis.</p>2<p>Adjusted for age and sex.</p>3<p>Adjusted for age (years), sex, height (per 10 cm), education level, fiber (g/d), total fatty acids (g/d), trans unsaturated fatty acid (g/d), mono unsaturated fat (g/d), poly unsaturated fat (g/d), carbohydrates (g/d) and niacin (mg/d).</p>4<p>Insufficient number of cases for analyses with tertiles (N>60 required) or with acrylamide as a continuous variable (N>20 required).</p>5<p>Proportional hazards assumption not met; therefore results not presented.</p

Association between continuously modeled dietary acrylamide intake (per 10 µg/d) and the risk of follicular lymphoma and Waldenstrom macroglobulinemia and immunocytoma (WMI); the Netherlands Cohort Study on diet and cancer, 1986–2002.¹

<p>HR  =  hazard ratio; CI  =  confidence interval; py  =  person years. The number of cases and person-years are the numbers that resulted after listwise deletion of observations with missing values for the selected confounders. HRs were calculated by using Cox proportional hazards analysis.</p>1<p>Adjusted for age and sex.</p>2<p>Adjusted for age (years), sex, height (per 10 cm), education level, fiber (g/d), total fatty acids (g/d), trans unsaturated fatty acid (g/d), mono unsaturated fat (g/d), poly unsaturated fat (g/d), carbohydrates (g/d) and niacin (mg/d).</p>3<p>Insufficient number of cases for analyses with acrylamide as a continuous variable (N>20 requiered).</p

Flow diagram of subcohort members and cases used in the analysis.

<p>NCR  =  Netherlands Cancer Registry, PALGA  =  Netherlands Pathology Registry, LM  =  lymphatic malignancies, MM  =  multiple myeloma, DLCL  =  diffuse large cell lymphoma, CLL  =  chronic lymphocytic leukaemia, FL  =  follicular lymphoma, WMI  =  Waldenstrom macroglobulinemia and immunocytoma, MCL  =  mantle cell lymphoma, T-cell  =  T-cell lymphoma.</p

Characteristics of cases and subcohort members according to sex in the Netherlands Cohort Study on diet and cancer, 1986–2002.

<p>MM  =  multiple myeloma; DLCL  =  diffuse large cell lymphoma; CLL  =  chronic lymphocytic leukemia; FL  =  follicular lymphoma; WMI  =  Waldenström macroglobulinemia and immunocytoma; MCL  =  mantle cell lymphoma; T-cell  =  T-cell lymphomas; BW  =  bodyweight; HM  =  hematological malignancies.</p>1<p>Mean (standard deviation) or percentage.</p>2<p>Among former or current smokers.</p

Acrylamide hazard ratios (and 95% CI) of multiple myeloma, diffuse large cell lymphoma and chronic lymphatic leukemia in <b>women</b> in strata of several covariables and <i>p</i> values for interaction: the Netherlands Cohort Study on diet and cancer, 1986–2002.

<p>Abbreviations: HR  =  hazard ratio; CI  =  confidence interval; AA/d  =  acrylamide per day, MM  =  multiple myeloma; CLL  =  chronic lymphatic leukemia; DLCL  =  diffuse large cell lymphoma.</p>1<p>Adjusted for age, sex, height (per 10 cm), education level, fiber (g/d), total fatty acids (g/d), trans unsaturated fatty acid (g/d), mono unsaturated fat (g/d), poly unsaturated fat (g/d), carbohydrates (g/d) and niacin (mg/d).</p>2<p>Insufficient number of cases.</p

Number of lymphatic malignancies in the Netherlands Cohort Study on diet and cancer (follow up: 16.3 years) according to the WHO classification.

<p>Abbreviations: ICD-O-3, International Classification of Diseases for Oncology, 3^rd edition; MALT, mucosa-associated lymphoid tissue; NOS, not otherwise specified.</p>1<p>N after exclusion of prevalent cases at baseline.</p>2<p>N cases available for analyses, after exclusion of missing and inconsistent data. Only case numbers for subtypes with sufficient number of cases are given (so subgroups do not add up to 1,233).</p