Fungal infections in HIV/AIDS.

Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or re-present with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially

Skew-Unfolding the Skorokhod Reflection of a Continuous Semimartingale

The Skorokhod reflection of a continuous semimartingale is unfolded, in a possibly skewed manner, into another continuous semimartingale on an enlarged probability space according to the excursion-theoretic methodology of Prokaj (2009). This is done in terms of a skew version of the Tanaka equation, whose properties are studied in some detail. The result is used to construct a system of two diffusive particles with rank-based characteristics and skew-elastic collisions. Unfoldings of conventional reflections are also discussed, as are examples involving skew Brownian Motions and skew Bessel processes.Comment: 20 pages. typos corrected, added a remark after Proposition 2.3, simplified the last part of Example 2.

Gravitational waves from first order phase transitions during inflation

We study the production, spectrum and detectability of gravitational waves in models of the early Universe where first order phase transitions occur during inflation. We consider all relevant sources. The self-consistency of the scenario strongly affects the features of the waves. The spectrum appears to be mainly sourced by collisions of bubble of the new phases, while plasma dynamics (turbulence) and the primordial gauge fields connected to the physics of the transitions are generally subdominant. The amplitude and frequency dependence of the spectrum for modes that exit the horizon during inflation are different from those of the waves produced by quantum vacuum oscillations of the metric or by first order phase transitions not occurring during inflation. A moderate number of slow (but still successful) phase transitions can leave detectable marks in the CMBR, but the signal weakens rapidly for faster transitions. When the number of phase transitions is instead large, the primordial gravitational waves can be observed both in the CMBR or with LISA (marginally) and especially DECIGO. We also discuss the nucleosynthesis bound and the constraints it places on the parameters of the models.Comment: minor changes in the text and the references to match the published versio

Contexts for children’s digital citizenship in India, Korea and Australia: A literature review

Children’s digital citizenship today: In an increasingly digitised and technically mediated world, an individual’s digital citizenship, or “ability to use digital technology and media in safe, responsible and ethical ways” (DQ Institute, 2019) has never been more relevant, particularly when it concerns our youngest digital citizens. Navigating online spaces safely and confidently are skills fundamental to a modern individual’s social and emotional development, education, work and play. A digital citizen’s abilities, however, are greatly impacted by notions of access; not just physical access, but also access mediated culturally and socio-economically. Less is known about very young children’s experiences of digital citizenship, and with recent pandemic related events accelerating a move to even greater online engagement, challenges posed to children’s digital citizenship development require thoughtful, child-led, culturally nuanced, and research-based solutions

The importance of layout and configuration data for flexibility during commissionning and operation of the LHC machine protection systems

Due to the large stored energies in both magnets and particle beams, the Large Hadron Collider (LHC) requires a large inventory of machine protection systems, as e.g. powering interlock systems, based on a series of distributed industrial controllers for the protection of the more than 10'000 normal and superconducting magnets. Such systems are required to be at the same time fast, reliable and secure but also flexible and configurable to allow for automated commissioning, remote monitoring and optimization during later operation. Based on the generic hardware architecture of the LHC machine protection systems presented at EPAC 2002 [2] and ICALEPS 2003, the use of configuration data for protection systems in view of the required reliability and safety is discussed. To achieve the very high level of reliability, it is required to use a coherent description of the layout of the accelerator components and of the associated machine protection architecture and their logical interconnections. Mechanisms to guarantee coherency of data and repositories and secure configuration of safety critical systems are presented. This paper focuses on the first system being commissioned, the complex magnet powering system, to become fully operational before first injection of beam into the LHC

Pathwise uniqueness of the squared Bessel and CIR processes with skew reflection on a deterministic time dependent curve

We investigate pathwise uniqueness for the squared Bessel and Cox-Ingersoll-Ross processes with additional reflection term that is multiplied by some real number strictly between minus one and one. The reflection term is the symmetric local time of the corresponding processes at a deterministic time dependent curve.Comment: Structured introduction and modified Section