Melioidosis: refining management of a tropical time bomb

10.1016/S0140-6736(13)62143-1The Lancet3839919762-764LANC

Theory of Quasi-Particles in the Underdoped High Tc Superconducting State

The microscopic theory of superconducting (SC) state in the SU(2) slave-boson model is developed. We show how the pseudogap and Fermi surface (FS) segments in the normal state develop into a d-wave gap in the superconducting state. Even though the superfluid density is of order x (the doping concentration), the physical properties of the low lying quasiparticles are found to resemble those in BCS theory. Thus the microscopic theory lay the foundation for our earlier phenomenological discussion of the unusual SC properties in the underdoped cuprates.Comment: 4 pages in RevTeX, 1 figure in eps, revised versio

The Solar Neighborhood. XXXIX. Parallax Results from the CTIOPI and NOFS Programs: 50 New Members of the 25 Parsec White Dwarf Sample

We present 114 trigonometric parallaxes for 107 nearby white dwarf (WD) systems from both the Cerro Tololo Inter-American Observatory Parallax Investigation (CTIOPI) and the U. S. Naval Observatory Flagstaff Station (NOFS) parallax programs. Of these, 76 parallaxes for 69 systems were measured by the CTIOPI program and 38 parallaxes for as many systems were measured by the NOFS program. A total of 50 systems are confirmed to be within the 25 pc horizon of interest. Coupled with a spectroscopic confirmation of a common proper motion companion to a Hipparcos star within 25 pc as well as confirmation parallax determinations for two WD systems included in the recently released Tycho Gaia Astrometric Solution (TGAS) catalog, we add 53 new systems to the 25 pc WD sample $-$ a 42% increase. Our sample presented here includes four strong candidate halo systems, a new metal-rich DAZ WD, a confirmation of a recently discovered nearby short-period (P = 2.85 hr) double degenerate, a WD with a new astrometric pertubation (long period, unconstrained with our data), and a new triple system where the WD companion main-sequence star has an astrometric perturbation (P $\sim$ 1.6 yr).Comment: 32 pages, 12 figures. Figure 4 in the manuscript is a representative set of plots - plots for all WDs presented here are available (allfits_photo.pdf, allfits_photo_DQ.pdf, and allfits_photo_DZ.pdf). Accepted for publication in The Astronomical Journa

Ab initio calculation of the 66 low lying electronic states of HeH+^+: adiabatic and diabatic representations

We present an ab initio study of the HeH$^+$ molecule. Using the quantum chemistry package MOLPRO and a large adapted basis set, we have calculated the adiabatic potential energy curves of the first 20 $^1 \Sigma^+$, 19 $^3\Sigma^+$, 12 $^1\Pi$, 9 $^3\Pi$, 4 $^1\Delta$ and 2 $^3\Delta$ electronic states of the ion in CASSCF and CI approaches. The results are compared with previous works. The radial and rotational non-adiabatic coupling matrix elements as well as the dipole moments are also calculated. The asymptotic behaviour of the potential energy curves and of the various couplings between the states is also studied. Using the radial couplings, the diabatic representation is defined and we present an example of our diabatization procedure on the $^1\Sigma^+$ states.Comment: v2. Minor text changes. 28 pages, 18 figures. accepted in J. Phys.

In vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam monotherapy with ceftazidime-avibactam-containing combination regimens against carbapenem-resistant Enterobacterales and multidrug-resistant Pseudomonas aeruginosa isolates or infections: a scoping review

IntroductionCarbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections.MethodsWe systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022. Review articles, grey literature, abstracts, comments, editorials, non-peer reviewed articles, non-English articles, and in vitro synergy studies conducted on single isolates were excluded.Results22 in vitro, 7 in vivo and 20 clinical studies were evaluated. In vitro studies showed reliable synergy between CZA and aztreonam against metallo-β-lactamase (MBL)-producing isolates. Some studies indicated good in vitro synergy between CZA and amikacin, meropenem, fosfomycin and polymyxins against CRE isolates. For MDR-PA isolates, there are comparatively fewer in vitro or in vivo studies. In observational clinical studies, mortality, clinical cure, adverse events, and development of CZA resistance after exposure were generally similar in monotherapy and combination therapy groups. However, antibiotic-related nephrotoxicity and infection relapses were higher in patients receiving CZA combination therapies.DiscussionThe benefit, if any, of CZA combination regimens in MDR-PA infections is elusive, as very few clinical studies have included these infections. There is no currently documented clinical benefit for the use of CZA combination regimens rather than CZA monotherapy. CZA combined with aztreonam for serious infections due to MBL producers should be evaluated by randomized controlled trials.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=278552, CRD42021278552

The Optical-Near-IR Spectrum of the M87 Jet From HST Observations

We present 1998 HST observations of M87 which yield the first single-epoch optical and radio-optical spectral index images of the jet at $0.15''$ resolution. We find $\approx 0.67$, comparable to previous measurements, and $\approx 0.9$ ($F_\nu \propto \nu^{-\alpha}$), slightly flatter than previous workers. Reasons for this discrepancy are discussed. These observations reveal a large variety of spectral slopes. Bright knots exhibit flatter spectra than interknot regions. The flattest spectra ($\alpha_o \sim 0.5-0.6$; comparable to or flatter than $\alpha_{ro}$) are found in two inner jet knots (D-East and HST-1) which contain the fastest superluminal components. In knots A, B and C, $\alpha_o$ and $\alpha_{ro}$ are essentially anti-correlated. Near the flux maxima of knots HST-1 and F, changes in $\alpha_{ro}$ lag changes in $\alpha_o$, but in knots D and E, the opposite relationship is observed. This is further evidence that radio and optical emissions in the M87 jet come from substantially different physical regions. The delays observed in the inner jet are consistent with localized particle acceleration, with $t_{acc} << t_{cool}$ for optically emitting electrons in knots HST-1 and F, and $t_{acc} \sim t_{cool}$ for optically emitting electrons in knots D and E. Synchrotron models yield \nu_B \gsim 10^{16} Hz for knots D, A and B, and somewhat lower values, $\nu_B \sim 10^{15}- 10^{16}$ Hz, in other regions. If X-ray emissions from knots A, B and D are co-spatial with optical and radio emission, we can strongly rule out the ``continuous injection'' model. Because of the short lifetimes of X-ray synchrotron emitting particles, the X-ray emission likely fills volumes much smaller than the optical emission regions.Comment: Text 17 pages, 3 Tables, 11 figures, accepted by Ap

The Hubble Constant from Observations of the Brightest Red Giant Stars in a Virgo-Cluster Galaxy

The Virgo and Fornax clusters of galaxies play central roles in determining the Hubble constant H_0. A powerful and direct way of establishing distances for elliptical galaxies is to use the luminosities of the brightest red-giant stars (the TRGB luminosity, at M_I = -4.2). Here we report the direct observation of the TRGB stars in a dwarf elliptical galaxy in the Virgo cluster. We find its distance to be 15.7 +- 1.5 Megaparsecs, from which we estimate a Hubble constant of H_0 = 77 +- 8 km/s/Mpc. Under the assumption of a low-density Universe with the simplest cosmology, the age of the Universe is no more than 12-13 billion years.Comment: 12 pages, LaTeX, with 2 postscript figures; in press for Nature, July 199

Staggered flux state of electron in two-dimensional t-J model

The competition between the staggered flux state, or the d-density wave state, and the d-wave pairing state is analyzed in two-dimensional t-J model based on the U(1) slave boson mean-field theory. Not only staggered flux of spinon but also staggered flux of holon are considered. In this formalism, the hopping order parameter of $physical$ electron is described by the product of hopping order parameters of spinon and holon. The staggered flux amplitude of electron is the difference of staggered flux amplitude of spinon and that of holon. In $\pi$-flux phase of spinon, staggered fluxes of spinon and holon cancel completely and staggered flux order of electron does not exist. However, in staggered flux phase of spinon whose staggered flux amplitude is not $\pi$, fluxes does not cancel completely and staggered flux amplitude of electron remains. Thus, the phase transition between these two phases, $\pi$-flux phase and staggered flux phase of spinon, becomes a second order transition in $physical$ electron picture. The order parameter which characterizes this transition is staggered flux order parameter of electron. A mean-field phase diagram is shown. It is proved analytically that there is no coexisistence of staggered flux and d-wave pairing. The temperature dependences of Fermi surface and excitation gap at $(0,\pi)$ are shown. These behaviors are consistent with angle-resolved photoemission spectroscopy (ARPES) experiments.Comment: 10 pages, 8 figure

MINERvA neutrino detector response measured with test beam data

The MINERvA collaboration operated a scaled-down replica of the solid scintillator tracking and sampling calorimeter regions of the MINERvA detector in a hadron test beam at the Fermilab Test Beam Facility. This article reports measurements with samples of protons, pions, and electrons from 0.35 to 2.0 GeV/c momentum. The calorimetric response to protons, pions, and electrons are obtained from these data. A measurement of the parameter in Birks' law and an estimate of the tracking efficiency are extracted from the proton sample. Overall the data are well described by a Geant4-based Monte Carlo simulation of the detector and particle interactions with agreements better than 4%, though some features of the data are not precisely modeled. These measurements are used to tune the MINERvA detector simulation and evaluate systematic uncertainties in support of the MINERvA neutrino cross section measurement program.Comment: as accepted by NIM

Long-term morbidity and mortality following bloodstream infection: a systematic literature review

Bloodstream infection results in significant short-term morbidity and mortality. No literature review has studied the long-term outcome following a bloodstream infection. This PROSPERO registered systematic review evaluated studies, which measured the association of a bloodstream infection with long-term morbidity and mortality.Databases were systematically searched for studies of adult patients reporting morbidity and/or mortality one year or more following a bloodstream infection in comparison to a matched cohort without a bloodstream infection.Ten observational studies were included in the final analysis. Five studies assessed only mortality, two assessed morbidity and mortality and three studies assessed morbidity only. The one year mortality ranged from between 8 and 48% for patients with bloodstream infection. The pooled risk ratio of death at one year was significantly higher for patients with bloodstream infection when compared to the matched cohort (RR 4.04 [95% CI 1.84-8.87]).Bloodstream infection was associated with poor long-term outcome measured at one year when compared to matched controls. More evidence is needed to determine if this association is causative