4 research outputs found
Principles of Biology I & II (GHC)
This Grants Collection for Principles of Biology I & II was created under a Round Eleven ALG Textbook Transformation Grant.
Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.
Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/biology-collections/1024/thumbnail.jp
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women
Background
Android fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low‐density lipoprotein (VLDL) particles in men. Since abdominal obesity is becoming increasingly prevalent in women, we aimed to investigate the relationship between android fat and hepatic lipid metabolism in pre‐ and postmenopausal women.
Methods and Results
We used a combination of stable isotope tracer techniques to investigate intrahepatic fatty acid synthesis and partitioning in 29 lean and 29 abdominally obese women (android fat/total fat 0.065 [0.02 to 0.08] and 0.095 [0.08 to 0.11], respectively). Thirty women were premenopausal aged 35 to 45 and they were matched for abdominal obesity with 28 postmenopausal women aged 55 to 65. As anticipated, abdominal obese women were more insulin resistant with enhanced hepatic secretion of large (404±30 versus 268±26 mg/kg lean mass,
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women
Background-Android fat distribution (abdominal obesity) is associated
with insulin resistance, hepatic steatosis, and greater secretion of
large very low-density lipoprotein (VLDL) particles in men. Since
abdominal obesity is becoming increasingly prevalent in women, we aimed
to investigate the relationship between android fat and hepatic lipid
metabolism in pre-and postmenopausal women.
Methods and Results-We used a combination of stable isotope tracer
techniques to investigate intrahepatic fatty acid synthesis and
partitioning in 29 lean and 29 abdominally obese women (android
fat/total fat 0.065 [0.02 to 0.08] and 0.095 [0.08 to 0.11],
respectively). Thirty women were premenopausal aged 35 to 45 and they
were matched for abdominal obesity with 28 postmenopausal women aged 55
to 65. As anticipated, abdominal obese women were more insulin resistant
with enhanced hepatic secretion of large (404 +/- 30 versus 268 +/- 26
mg/kg lean mass, P<0.001) but not small VLDL (160 +/- 11 versus 142 +/-
13). However, postmenopausal status had a pronounced effect on the
characteristics of small VLDL particles, which were considerably
triglyceride-enriched (production ratio of VLDL2-triglyceride:
apolipoprotein B 30 +/- 5.3 versus 19 +/- 1.6, P<0.05). In contrast to
postmenopausal women, there was a tight control of hepatic fatty acid
metabolism and triglyceride production in premenopausal women, whereby
oxidation (r(s)=-0.49, P=0.006), de novo lipogenesis (r(s)=0.55,
P=0.003), and desaturation (r(s)=0.48, P=0.012) were closely correlated
with abdominal obesity-driven large VLDL-triglyceride secretion rate.
Conclusions-In women, abdominal obesity is a major driver of hepatic
large VLDL particle secretion, whereas postmenopausal status was
characterized by increased small VLDL particle size. These data provide
a mechanistic basis for the hyperlipidemia observed in postmenopausal
obesity