67 research outputs found
Classification of Supernovae
The current classification scheme for supernovae is presented. The main
observational features of the supernova types are described and the physical
implications briefly addressed. Differences between the homogeneous
thermonuclear type Ia and similarities among the heterogeneous core collapse
type Ib, Ic and II are highlighted. Transforming type IIb, narrow line type
IIn, supernovae associated with GRBs and few peculiar objects are also
discussed.Comment: 16 Pages, 4 figures, to be published in "Supernovae and Gamma-Ray
Bursters," ed. Kurt W. Weile
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Background
Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.
Methods
Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene–environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.
Results
Assuming a 1 × 10–5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92–0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88–0.94).
Conclusions
Overall, the contribution of GĂ—E interactions to the heritability of breast cancer is very small. At the population level, multiplicative GĂ—E interactions do not make an important contribution to risk prediction in breast cancer
Late Quaternary primary tephras in Sacred Lake sediments, northeast Mount Kenya, Kenya
In this paper, a sequence of five Late Quaternary tephras occurring as discrete, well-preserved horizons in lake sediments on the northeastern flank of Mount Kenya are characterised and their ages determined by a combination of high-resolution indirect radiocarbon dating and direct U/Th dating. The grain size characteristics suggest that the tephras are of fairly local origin. These Na-K-rich alkali pyroclasts with a trachytic chemical composition have a highly correlated chemistry and mineralogy, suggesting that they were probably derived from the same genetic series and possibly erupted from a single source vent. Morphological differences are attributed to the peculiar characteristics of each eruption episode. The magma source was probably a small, highly differentiated magma chamber following the olivine basalt-trachyandesite-trachyte-phonolite series, which broadly reflects the Quaternary rock suite of Mount Kenya
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