Binding affinity of Hangzhou-H7 and H7N7 for human and avian receptors.

<p>Hangzhou-H7 and the closely related H7N7 virus (A/Netherlands/219/2003) were docked to human and avian sialic acid receptors and affinities calculated. (<b>A</b>) The predicted Hangzhou-H7 model receptor affinities are shown by the black bars and the A/Netherlands/219/2003 affinities by the white bars. (<b>B</b>) The highest affinity docking conformation of Hangzhou-H7 on the human (brown), and avian (purple), receptors. HA mutations that influence the receptor binding specificity are highlighted in red and other residues that interact with the receptor in yellow. Residues that form the receptor-binding pocket are highlighted in green.</p

Hangzhou-H7 neutralizing antibody binding.

<p>(<b>A</b>) The structures of neutralizing antibodies are shown either binding to the Hangzhou-H7 (shown in blue) globular head region (left figure) or stalk region (right figure). Different colours represent different antibodies. HA residues interacting with stalk-binding neutralizing antibodies are shown in the right hand figure highlighted in yellow. (B) HA-neutralizing antibodies binding the head or stalk regions were docked to the predicted Hangzhou-H7 structure and binding energies were calculated and presented as an absolute value. PDB IDs of antibodies against H1 are 3LZF, 3SM5, 4M5Z, 3GBN, 3ZTN, PDB IDs for H3 are 1EO8, 1KEN, 1QFU, 2VIR, 4FQR, 3SDY, 4NM8, H5 PDB IDs are 3FKU and 3GBM and H7 ID is 4FQV.</p