Synthesis of 3-(5-phenyl-1, 3, 4-oxadiazol-2-yl)-2<em>H</em>-chromen-2-ones as anticonvulsant agents

737-7453-(5-Phenyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one (IVa-IVl) have been synthesized from N-benzylidene2-oxo-2H-chromene-3-carbohydrazide (IIIa-IIIl). The structure of synthesized coumarinyl oxadiazoles have been established by spectral data, elemental analysis and alternative synthetic routes wherever possible. These compounds have been screened for their anticonvulsant activity by using MES and PTZ models. Coumarinyl oxadiazoles have shown potential anticonvlsant activity. Compound IVb shows very good anticonvulsant activity both in MES and PTZ models