6,723 research outputs found
The Impact of Greenspace, Walking, and Cycling on the Health of Urban Residents during the COVID-19 Pandemic: A Study of London
Vulnerability to COVID-19 has been linked to public health issues like obesity and physical fitness, which consecutively can be linked to access to urban greenspace. However, the value of greenspaces remains contentious in the literature and unclear in practice. In view of very high COVID-19 mortality rates, we use data from London boroughs to explore the impact of green infrastructure in terms of the size, accessibility, and support of physical activity and healthy lifestyles (e.g., walking and cycling). Results show no significant relationship between the availability of greenspace and the probability of being obese or dying from COVID-19. Cycling once, thrice, or five times weekly was found to improve healthy weight, as does cycling once a month. However, the probability of dying from COVID-19 during lockdowns is correlated to the frequency of walking or cycling as a result of decreased social distancing, while the frequency of walking and cycling is determined by availability and access to greenspace
On Recurrent Reachability for Continuous Linear Dynamical Systems
The continuous evolution of a wide variety of systems, including
continuous-time Markov chains and linear hybrid automata, can be described in
terms of linear differential equations. In this paper we study the decision
problem of whether the solution of a system of linear
differential equations reaches a target
halfspace infinitely often. This recurrent reachability problem can
equivalently be formulated as the following Infinite Zeros Problem: does a
real-valued function satisfying a
given linear differential equation have infinitely many zeros? Our main
decidability result is that if the differential equation has order at most ,
then the Infinite Zeros Problem is decidable. On the other hand, we show that a
decision procedure for the Infinite Zeros Problem at order (and above)
would entail a major breakthrough in Diophantine Approximation, specifically an
algorithm for computing the Lagrange constants of arbitrary real algebraic
numbers to arbitrary precision.Comment: Full version of paper at LICS'1
Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments
Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport, and subcellular compartmentation of phosphate. In addition, phosphite induces plant defence responses by an as yet unknown mode of action. In this study, the acclimation of Arabidopsis thaliana plants to a sustained phosphite supply in the growth medium was investigated and compared with plants growing under varying phosphate supplies. Unlike phosphate, phosphite did not suppress the formation of lateral roots in several Arabidopsis accessions. In addition, the expression of well-documented phosphate-starvation-induced genes, such as miRNA399d and At4, was not repressed by phosphite accumulation, whilst the induction of PHT1;1 and PAP1 was accentuated. Thus, a mimicking of phosphate by phosphite was not observed for these classical phosphate-starvation responses. Metabolomic analysis of phosphite-treated plants showed changes in several metabolite pools, most prominently those of aspartate, asparagine, glutamate, and serine. These alterations in amino acid pools provide novel insights for the understanding of phosphite-induced pathogen resistance
On relativistic elements of reality
Several arguments have been proposed some years ago, attempting to prove the
impossibility of defining Lorentz-invariant elements of reality. I find that a
sufficient condition for the existence of elements of reality, introduced in
these proofs, seems to be used also as a necessary condition. I argue that
Lorentz-invariant elements of reality can be defined but, as Vaidman pointed
out, they won't satisfy the so-called product rule. In so doing I obtain
algebraic constraints on elements of reality associated with a maximal set of
commuting Hermitian operators.Comment: Clarifications, reference added; published versio
A measure of majorisation emerging from single-shot statistical mechanics
The use of the von Neumann entropy in formulating the laws of thermodynamics
has recently been challenged. It is associated with the average work whereas
the work guaranteed to be extracted in any single run of an experiment is the
more interesting quantity in general. We show that an expression that
quantifies majorisation determines the optimal guaranteed work. We argue it
should therefore be the central quantity of statistical mechanics, rather than
the von Neumann entropy. In the limit of many identical and independent
subsystems (asymptotic i.i.d) the von Neumann entropy expressions are recovered
but in the non-equilbrium regime the optimal guaranteed work can be radically
different to the optimal average. Moreover our measure of majorisation governs
which evolutions can be realized via thermal interactions, whereas the
nondecrease of the von Neumann entropy is not sufficiently restrictive. Our
results are inspired by single-shot information theory.Comment: 54 pages (15+39), 9 figures. Changed title / changed presentation,
same main results / added minor result on pure bipartite state entanglement
(appendix G) / near to published versio
Gravitational Microlensing Near Caustics I: Folds
We study the local behavior of gravitational lensing near fold catastrophes.
Using a generic form for the lensing map near a fold, we determine the
observable properties of the lensed images, focusing on the case when the
individual images are unresolved, i.e., microlensing. Allowing for images not
associated with the fold, we derive analytic expressions for the photometric
and astrometric behavior near a generic fold caustic. We show how this form
reduces to the more familiar linear caustic, which lenses a nearby source into
two images which have equal magnification, opposite parity, and are equidistant
from the critical curve. In this case, the simplicity and high degree of
symmetry allows for the derivation of semi-analytic expressions for the
photometric and astrometric deviations in the presence of finite sources with
arbitrary surface brightness profiles. We use our results to derive some basic
properties of astrometric microlensing near folds, in particular we predict for
finite sources with uniform and limb darkening profiles, the detailed shape of
the astrometric curve as the source crosses a fold. We find that the
astrometric effects of limb darkening will be difficult to detect with the
currently planned accuracy of the Space Interferometry Mission. We verify our
results by numerically calculating the expected astrometric shift for the
photometrically well-covered Galactic binary lensing event OGLE-1999-BUL-23,
finding excellent agreement with our analytic expressions. Our results can be
applied to any lensing system with fold caustics, including Galactic binary
lenses and quasar microlensing.Comment: 37 pages, 7 figures. Revised version includes an expanded discussion
of applications. Accepted to ApJ, to appear in the August 1, 2002 issue
(v574
Epigenomics of Ovarian Cancer and Its Chemoprevention
Ovarian cancer is a major cause of death among gynecological cancers and its etiology is still unclear. Currently, the two principle obstacles in treating this life threatening disease are lack of effective biomarkers for early detection and drug resistance after initial chemotherapy. Similar to other cancers, the initiation and development of ovarian cancer is characterized by disruption of oncogenes and tumor suppressor genes by both genetic and epigenetic mechanisms. While it is well known that it is challenging to treat ovarian cancer through a genetic strategy due in part to its heterogeneity, the reversibility of epigenetic mechanisms involved in ovarian cancer opens exciting new avenues for treatment. The epigenomics of ovarian cancer has therefore become a rapidly expanding field leading to intense investigation. A review on the current status of the field is thus warranted. In this analysis, we will evaluate the current status of epigenomics of ovarian cancer and will include epigenetic mechanisms involved in ovarian cancer development such as DNA methylation, histone modifications, and non-coding microRNA. Development of biomarkers, the epigenetic basis for drug resistance and improved chemotherapy for ovarian cancer will also be assessed. In addition, the potential use of natural compounds as epigenetic modulators in chemotherapy shows promise in moving to the forefront of ovarian cancer treatment strategies
Two types of nematicity in the phase diagram of the cuprate superconductor YBaCuO
Nematicity has emerged as a key feature of cuprate superconductors, but its
link to other fundamental properties such as superconductivity, charge order
and the pseudogap remains unclear. Here we use measurements of transport
anisotropy in YBaCuO to distinguish two types of nematicity. The
first is associated with short-range charge-density-wave modulations in a
doping region near . It is detected in the Nernst coefficient, but
not in the resistivity. The second type prevails at lower doping, where there
are spin modulations but no charge modulations. In this case, the onset of
in-plane anisotropy - detected in both the Nernst coefficient and the
resistivity - follows a line in the temperature-doping phase diagram that
tracks the pseudogap energy. We discuss two possible scenarios for the latter
nematicity.Comment: 8 pages and 7 figures. Main text and supplementary material now
combined into single articl
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