Unequal a priori Probability Multiple Hypothesis Testing in Space Domain Awareness with the Space Surveillance Telescope

This paper investigates the ability to improve Space Domain Awareness (SDA) by increasing the number of detectable Resident Space Objects (RSOs) from space surveillance sensors. With matched filter based techniques, the expected impulse response, or Point Spread Function (PSF), is compared against the received data. In the situation where the images are spatially undersampled, the modeled PSF may not match the received data if the RSO does not fall in the center of the pixel. This aliasing can be accounted for with a Multiple Hypothesis Test (MHT). Previously, proposed MHTs have implemented a test with an equal a priori prior probability assumption. This paper investigates using an unequal a priori probability MHT. To determine accurate a priori probabilities, three metrics are computed; they are correlation, physical distance, and empirical. Using the calculated a priori probabilities, a new algorithm is developed, and images from the Space Surveillance Telescope (SST) are analyzed. The number of detected objects by both an equal and unequal prior probabilities are compared while keeping the false alarm rate constant. Any additional number of detected objects will help improve SDA capabilities. Abstract © 2016 Optical Society of Americ

Student led social work clinic hub: Increasing capacity in challenging contexts

Social work and human services (SWHS) field education continues to experience challenges in securing quality practicums. Increasing competition through multiple schools of SW&HS, increased enrolments, government cut backs to services resulting in ongoing insecurity around roles and the future of services and their capacity, have all created a landscape where organisational capacity to offer practicums continues to reduce. Added to this is the availability of appropriately qualified on site social workers to supervise students. Student led clinics are not a new concept; they provide an innovative and creative way to provide quality and meaningful placement experiences for students while also creating increased capacity in services offered. In this presentation we discuss the progress of a newly developed Social Work student hub based with the QUT Health Clinics at QUT as part of the School of Public Health and Social Work. The Social Work student hub will commence in July 2014 with a significant focus on the Vision Rehabilitation Centre. The aim of introducing social work services was to increase the capacity of existing psychosocial service offerings in the Vision Rehabilitation Centre and introduce services to the QUT Health Clinics, including provision of outreach services to community organisations

The driver landscape of sporadic chordoma.

Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T) in up to 27% of cases. These variants recapitulate the rearrangement architecture of the pathogenic germline duplications of T that underlie familial chordoma. In addition, we find potentially clinically actionable PI3K signalling mutations in 16% of cases. Intriguingly, one of the most frequently altered genes, mutated exclusively by inactivating mutation, was LYST (10%), which may represent a novel cancer gene in chordoma.Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma

Digital tools for brownfield redevelopment: Stakeholder perspectives and opportunities

Brownfield redevelopment is a complex process often involving a wide range of stakeholders holding differing priorities and opinions. The use of digital systems and products for decision making, modelling, and supporting discussion has been recognised throughout literature and industry. The inclusion of stakeholder preferences is an important consideration in the design and development of impactful digital tools and decision support systems. In this study, we present findings from stakeholder consultation with professionals from the UK brownfield sector with the aim of informing the design of future digital tools and systems. Our research investigates two broad themes; digitalisation and the use of digital tools across the sector; and perceptions of key brownfield challenge areas where digital tools could help better inform decision-makers. The methodology employed for this study comprises the collection of data and information using a combination of interviews and an online questionnaire. The results from these methods were evaluated both qualitatively and quantitatively. Findings reveal a disparity in levels of digital capability between stakeholder groups including between technical stakeholder types, and that cross-discipline communication of important issues may be aided by the development of carefully designed digital tools. To this end, we present seven core principles to guide the design and implementation of future digital tools for the brownfield sector. These principles are that future digital tools should be: (1) Stakeholder driven, (2) Problem centred, (3) Visual, (4) Intuitive, (5) Interactive, (6) Interoperable, and (7) Geospatial data driven

Study protocol : E-freeze-freezing of embryos in assisted conception: A randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation

Acknowledgements The E-Freeze Collaborators Group contributed to the overall design of the E-Freeze trial. Funding The trial is approved and funded by the National Institute of Health Research (NIHR) Health Technology Assessment (HTA) programme. Availability of data and materials Applications for data sharing should be made to the NPEU CTU, using [email protected], with an accompanying protocol for the intended use of the data. This will be reviewed by the Trial Steering Committee if still operational or Data Sharing Committee/Data Controller. If approved, a Data Sharing Agreement will be compiled laying out the conditions to which the requestor must abide. Protocol E-Freeze Protocol, Version 2.0 (18/01/2017). Author notes All authors contributed equally to this work.Peer reviewedPublisher PD