Towards Diverse and Consistent Typography Generation

In this work, we consider the typography generation task that aims at producing diverse typographic styling for the given graphic document. We formulate typography generation as a fine-grained attribute generation for multiple text elements and build an autoregressive model to generate diverse typography that matches the input design context. We further propose a simple yet effective sampling approach that respects the consistency and distinction principle of typography so that generated examples share consistent typographic styling across text elements. Our empirical study shows that our model successfully generates diverse typographic designs while preserving a consistent typographic structure

Adenine-and-Uridine-rich element RNA-binding factor 1 (AUF1) as an additional marker in human gliomas

AUF1 is one of Adenine-and-Uridine-rich elements binding protein which regulates the mRNA stability of many genes related to growth regulation, cytokines, and cell cycle-regulatory genes. There was no report about the expression of AUF1 in gliomas. Sections of formalin-fixed, paraffin-embedded tissues from 71 gliomas were stained immunohistochemically using a polyclonal antibody against the adenine-and-uridine-rich element RNA-Binding factor 1 (AUF1) oncoprotein. Positive staining, which is known to correlate with gene amplification, was not associated with patients\u27 sex, age, Karnofsky performance status scores (KPS), tumor size, Bcl-2 expression, or longer overall survival. However, positive staining was negatively correlated with the MIB-1 labeling index, while it was positively correlated with the lower grade group of WHO classification. Expression of the AUF1 oncoprotein appears to be an important additional indicator in human gliomas

All-in-one platform for AI R&D in medical imaging, encompassing data collection, selection, annotation, and pre-processing

Deep Learning is advancing medical imaging Research and Development (R&D), leading to the frequent clinical use of Artificial Intelligence/Machine Learning (AI/ML)-based medical devices. However, to advance AI R&D, two challenges arise: 1) significant data imbalance, with most data from Europe/America and under 10% from Asia, despite its 60% global population share; and 2) hefty time and investment needed to curate proprietary datasets for commercial use. In response, we established the first commercial medical imaging platform, encompassing steps like: 1) data collection, 2) data selection, 3) annotation, and 4) pre-processing. Moreover, we focus on harnessing under-represented data from Japan and broader Asia, including Computed Tomography, Magnetic Resonance Imaging, and Whole Slide Imaging scans. Using the collected data, we are preparing/providing ready-to-use datasets for medical AI R&D by 1) offering these datasets to AI firms, biopharma, and medical device makers and 2) using them as training/test data to develop tailored AI solutions for such entities. We also aim to merge Blockchain for data security and plan to synthesize rare disease data via generative AI. DataHub Website: https://medical-datahub.ai/Comment: 5 pages, 3 figures, accepted to SPIE Medical Imaging 202

Current status of a helicopter transportation system on remote islands for patients undergoing mechanical thrombectomy

Background: Mechanical thrombectomy (MT) is standard treatment for acute ischemic stroke (AIS) with large-vessel occlusion within 6 h of symptom onset to treatment initiation (OTP). Recent trials have extended the therapeutic time window for MT to within 24 h. However, MT treatment remains low in remote areas. Nagasaki Prefecture, Japan has many inhabited islands with no neurointerventionalists. Our hospital on the mainland is a regional hub for eight island hospitals. We evaluated clinical outcomes of MT for patients with AIS on these islands versus on the mainland. Methods: During 2014–2019, we reviewed consecutive patients with AIS who received MT at our hospital. Patients comprised the Islands group and Mainland group. Patient characteristics and clinical outcomes were compared between groups. Results: We included 91 patients (Islands group: 15 patients, Mainland group: 76 patients). Seven patients (46.7%) in the Islands group versus 43 (56.6%) in the Mainland group achieved favorable outcomes. Successful recanalization was obtained in 11 patients (73.3%) on the islands and 67 (88.2%) on the mainland. The median OTP time in the Islands was 365 min. In both the Islands and Mainland groups, the OTP time and successful recanalization were associated with functional outcome. The modified Rankin Scale (mRS) score at 90 days ≤2 was obtained in two patients and mRS = 3 in four patients among eight patients with OTP time >6 h. Conclusions: Few patients with AIS on remote islands have received MT. Although patients who underwent MT on the islands had longer OTP, the clinical outcomes were acceptable. OTP time on remote islands must be shortened, as this is related to functional outcome. In some cases with successful recanalization, a favorable outcome can still be obtained even after 6 h. Even if OTP exceeds 6 h, it is desirable to appropriately select patients and actively perform MT

Indian Monsoonal Variations During the Past 80 Kyr Recorded in NGHP-02 Hole 19B, Western Bay of Bengal: Implications From Chemical and Mineral Properties

金沢大学理工研究域地球社会基盤学系Detailed reconstruction of Indian summer monsoons is necessary to better understand the late Quaternary climate history of the Bay of Bengal and Indian peninsula. We established a chronostratigraphy for a sediment core from Hole 19B in the western Bay of Bengal, extending to approximately 80 kyr BP and examined major and trace element compositions and clay mineral components of the sediments. Higher δ 18 O values, lower TiO 2 contents, and weaker weathering in the sediment source area during marine isotope stages (MIS) 2 and 4 compared to MIS 1, 3, and 5 are explained by increased Indian summer monsoonal precipitation and river discharge around the western Bay of Bengal. Clay mineral and chemical components indicate a felsic sediment source, suggesting the Precambrian gneissic complex of the eastern Indian peninsula as the dominant sediment source at this site since 80 kyr. Trace element ratios (Cr/Th, Th/Sc, Th/Co, La/Cr, and Eu/Eu*) indicate increased sediment contributions from mafic rocks during MIS 2 and 4. We interpret these results as reflecting the changing influences of the eastern and western branches of the Indian summer monsoon and a greater decrease in rainfall in the eastern and northeastern parts of the Indian peninsula than in the western part during MIS 2 and 4. © 2018. American Geophysical Union. All Rights Reserved

Total Disentanglement of Font Images into Style and Character Class Features

In this paper, we demonstrate a total disentanglement of font images. Total disentanglement is a neural network-based method for decomposing each font image nonlinearly and completely into its style and content (i.e., character class) features. It uses a simple but careful training procedure to extract the common style feature from all `A'-`Z' images in the same font and the common content feature from all `A' (or another class) images in different fonts. These disentangled features guarantee the reconstruction of the original font image. Various experiments have been conducted to understand the performance of total disentanglement. First, it is demonstrated that total disentanglement is achievable with very high accuracy; this is experimental proof of the long-standing open question, ``Does `A'-ness exist?'' Hofstadter (1985). Second, it is demonstrated that the disentangled features produced by total disentanglement apply to a variety of tasks, including font recognition, character recognition, and one-shot font image generation

Efficacy of the Drip and Ship Method in 24-h Helicopter Transportation and Teleradiology for Isolated Islands

Our hospital, located on the mainland, serves as a hub center for nine hospitals on the remote islands of Nagasaki Prefecture, Japan. There are no stroke specialists on these islands. We can transfer emergency patients from these islands to our hospital at any time, using a teleradiology system and three types of helicopter transport. We examined the efficacy of the drip and ship (DS) method for treating patients with acute ischemic stroke (AIS) on these islands, in comparison with patients on the mainland. From 2010 to 2017, we reviewed 98 consecutive patients with AIS who received intravenous recombinant tissue plasminogen activator (IV rt-PA) in our hospital or were transported to our hospital after IV rt-PA. Patients were divided into the Islands group (received IV rt-PA on the islands, DS; 31 cases) and the Mainland group (67 cases). The median transport distance from the islands was 112 km. The rate of patients achieving favorable outcomes was 54.8% in the Islands group and 64.2% in the Mainland group, with no significant differences. Multivariate analysis revealed that patients living on isolated islands did not have increased risks of unfavorable outcomes. Endovascular therapy (EVT), as part of the drip, ship, and retrieve method, was performed in 22.6% of patients in the Islands group and EVT in 38.8% of those in the Mainland group. The DS method seems feasible and safe for patients living on isolated islands with the use of 24-h helicopter transportation and teleradiology

Efficacy of the Drip and Ship Method in 24-h Helicopter Transportation and Teleradiology for Isolated Islands

Our hospital, located on the mainland, serves as a hub center for nine hospitals on the remote islands of Nagasaki Prefecture, Japan. There are no stroke specialists on these islands. We can transfer emergency patients from these islands to our hospital at any time, using a teleradiology system and three types of helicopter transport. We examined the efficacy of the drip and ship (DS) method for treating patients with acute ischemic stroke (AIS) on these islands, in comparison with patients on the mainland. From 2010 to 2017, we reviewed 98 consecutive patients with AIS who received intravenous recombinant tissue plasminogen activator (IV rt-PA) in our hospital or were transported to our hospital after IV rt-PA. Patients were divided into the Islands group (received IV rt-PA on the islands, DS; 31 cases) and the Mainland group (67 cases). The median transport distance from the islands was 112 km. The rate of patients achieving favorable outcomes was 54.8% in the Islands group and 64.2% in the Mainland group, with no significant differences. Multivariate analysis revealed that patients living on isolated islands did not have increased risks of unfavorable outcomes. Endovascular therapy (EVT), as part of the drip, ship, and retrieve method, was performed in 22.6% of patients in the Islands group and EVT in 38.8% of those in the Mainland group. The DS method seems feasible and safe for patients living on isolated islands with the use of 24-h helicopter transportation and teleradiology