Cyclosporine: A Review

The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has since led to the widely accepted view that there is a chronic more irreversible component to this agent as well. Since that time, there has been intense interest in finding protocols which seek to minimize and even avoid the use of calcineurin inhibitors altogether. We seek to review cyclosporine in terms of its mechanism of action, pathophysiologic, and histologic features associated with acute and chronic nephrotoxicity and recent studies looking to avoid its toxic side effects

THE NECTAR SECRETION OF MAPLE (ACER PLATANOIDES L.) AND SYCAMORE (A. PSEUDOPLATANUS L.)

International audienc

EFFET PATHOGÈNE DES EXOTOXINES DE 11 VARIÉTÉS APPARTENANT AU GROUPE DE BACILLUS THURINGIENSIS BERLINER, SUR L'ABEILLE DOMESTIQUE

International audienc

Cyclosporine: a review

The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has since led to the widely accepted view that there is a chronic more irreversible component to this agent as well. Since that time, there has been intense interest in finding protocols which seek to minimize and even avoid the use of calcineurin inhibitors altogether. We seek to review cyclosporine in terms of its mechanism of action, pathophysiologic, and histologic features associated with acute and chronic nephrotoxicity and recent studies looking to avoid its toxic side effects

EFFET PATHOGÈNE COMPARÉ DE 12 SOUCHES DE BACILLUS THURINGIENSIS BERL. SUR L'ABEILLE DOMESTIQUE ET SON COUVAIN

International audienc

Renal Disease in HIV: Practical Aspects for Nephrologists

Patients with HIV represents a unique and often seemingly daunting challenge for nephrologists, as these patients often have many multi-system issues, and are on a mix of medications that are not well known or often prescribed by non-infectious disease specialists. HIV is a risk factor for acute kidney injury (AKI)/ chronic kidney disease (CKD), and there is a wide spectrum of renal disease that occurs in these patients, including those directly caused by the virus, and medication toxicities. Once the renal disease is advanced, these patients can also provoke difficult decisions regarding the issues of kidney biopsy, dialysis, and transplant. The nephrologist requires a working knowledge of the current state of overall HIV management, so that they can help with the prevention and treatment of acute and chronic kidney disease, within the multi-disciplinary HIV team