38 research outputs found
Cyclosporine: A Review
The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has since led to the widely accepted view that there is a chronic more irreversible component to this agent as well. Since that time, there has been intense interest in finding protocols which seek to minimize and even avoid the use of calcineurin inhibitors altogether. We seek to review cyclosporine in terms of its mechanism of action, pathophysiologic, and histologic features associated with acute and chronic nephrotoxicity and recent studies looking to avoid its toxic side effects
THE NECTAR SECRETION OF MAPLE (ACER PLATANOIDES L.) AND SYCAMORE (A. PSEUDOPLATANUS L.)
International audienc
EFFET PATHOGÈNE DES EXOTOXINES DE 11 VARIÉTÉS APPARTENANT AU GROUPE DE BACILLUS THURINGIENSIS BERLINER, SUR L'ABEILLE DOMESTIQUE
International audienc
Cyclosporine: a review
The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing. The finding of acute reversible nephrotoxicity and nephrotoxicity in nonrenal transplants has since led to the widely accepted view that there is a chronic more irreversible component to this agent as well. Since that time, there has been intense interest in finding protocols which seek to minimize and even avoid the use of calcineurin inhibitors altogether. We seek to review cyclosporine in terms of its mechanism of action, pathophysiologic, and histologic features associated with acute and chronic nephrotoxicity and recent studies looking to avoid its toxic side effects
EFFET PATHOGÈNE COMPARÉ DE 12 SOUCHES DE BACILLUS THURINGIENSIS BERL. SUR L'ABEILLE DOMESTIQUE ET SON COUVAIN
International audienc
EFFET PATHOGÈNE DES EXOTOXINES DE 11 VARIÉTÉS APPARTENANT AU GROUPE DE BACILLUS THURINGIENSIS BERLINER, SUR L'ABEILLE DOMESTIQUE
Renal Disease in HIV: Practical Aspects for Nephrologists
Patients with HIV represents a unique and often seemingly
daunting challenge for nephrologists, as these patients often have
many multi-system issues, and are on a mix of medications that
are not well known or often prescribed by non-infectious disease
specialists. HIV is a risk factor for acute kidney injury (AKI)/
chronic kidney disease (CKD), and there is a wide spectrum of
renal disease that occurs in these patients, including those directly
caused by the virus, and medication toxicities. Once the renal
disease is advanced, these patients can also provoke difficult
decisions regarding the issues of kidney biopsy, dialysis, and
transplant. The nephrologist requires a working knowledge of the
current state of overall HIV management, so that they can help
with the prevention and treatment of acute and chronic kidney
disease, within the multi-disciplinary HIV team