Log-based Anomaly Detection of CPS Using a Statistical Method

Detecting anomalies of a cyber physical system (CPS), which is a complex system consisting of both physical and software parts, is important because a CPS often operates autonomously in an unpredictable environment. However, because of the ever-changing nature and lack of a precise model for a CPS, detecting anomalies is still a challenging task. To address this problem, we propose applying an outlier detection method to a CPS log. By using a log obtained from an actual aquarium management system, we evaluated the effectiveness of our proposed method by analyzing outliers that it detected. By investigating the outliers with the developer of the system, we confirmed that some outliers indicate actual faults in the system. For example, our method detected failures of mutual exclusion in the control system that were unknown to the developer. Our method also detected transient losses of functionalities and unexpected reboots. On the other hand, our method did not detect anomalies that were too many and similar. In addition, our method reported rare but unproblematic concurrent combinations of operations as anomalies. Thus, our approach is effective at finding anomalies, but there is still room for improvement

The Optimal Cut-offValue of Ankle Brachial Index for Screening Cardiovascular Disease Risk in Hemodialysis Patients

Article信州医学雑誌 64(3): 135-146(2016)journal articl

A New Basis Function Approach to 't Hooft-Bergknoff-Eller Equations

We analytically and numerically investigate the 't Hooft-Bergknoff-Eller equations, the lowest order mesonic Light-Front Tamm-Dancoff equations for U(N_C) and SU(N_C) gauge theories. We find the wavefunction can be well approximated by new basis functions and obtain an analytic formula for the mass of the lightest bound state. Its value is consistent with the precedent results.Comment: 16 pages, 3 figure

Leukocytapheresis Therapy Improved Cholestasis in a Patient Suffering from Primary Sclerosing Cholangitis with Ulcerative Colitis

Primary sclerosing cholangitis (PSC) is an autoimmune disease of the hepatobiliary system for which effective therapy has not been established. Leukocytapheresis (LCAP) therapy is known to effective in patients with ulcerative colitis (UC). In addition, effects of LCAP therapy were reported on some autoimmune diseases such as Crohn's disease, rheumatoid arthritis and rapidly progressive glomerulonephritis. Here we report the case of a 29-year-old man with PSC associated with UC who was treated with LCAP therapy. He had a 16-year history of UC and a 12-year history of PSC. Although he was under treatment with prednisolone and ursodeoxycholic acid, exacerbation of UC and PSC-associated cholestasis were seen. Since he showed side effects of prednisolone, he was treated with LCAP. Not only improvement of UC, but also decreased serum alkaline phosphatase, γ-guanosine triphosphate and total bile acids, suggesting improvement of PSC-associated cholestaisis, were seen after treatment with LCAP. Our experience with this case suggests that LCAP therapy could be a new effective therapeutic strategy for patients with PSC associated with UC

SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor hypoxia and a rational target to overcome it have been sought to realize personalized radiotherapy. Here, we show that serine protease inhibitor Kazal type I (SPINK1) meets these 2 criteria. SPINK1 expression was induced upon hypoxia (O2 < 0.1%) at the transcription initiation level in a HIF-dependent manner, causing an increase in secreted SPINK1 levels. SPINK1 proteins were detected both within and around hypoxic regions of xenografted and clinical tumor tissues, and their plasma levels increased in response to decreased oxygen supply to xenografts. Secreted SPINK1 proteins enhanced radioresistance of cancer cells even under normoxic conditions in EGFR-dependent and nuclear factor erythroid 2–related factor 2–dependent (Nrf2-dependent) manners and accelerated tumor growth after radiotherapy. An anti-SPINK1 neutralizing antibody exhibited a radiosensitizing effect. These results suggest that SPINK1 secreted from hypoxic cells protects the surrounding and relatively oxygenated cancer cells from radiation in a paracrine manner, justifying the use of SPINK1 as a target for radiosensitization and a plasma marker for predicting tumor hypoxia

Research and development for accuracy improvement of neutron nuclear data on minor actinides

To improve accuracy of neutron nuclear data on minor actinides, a Japanese nuclear data project entitled “Research and development for Accuracy Improvement of neutron nuclear data on Minor ACtinides (AIMAC)” has been implemented. Several independent measurement techniques were developed for improving measurement precision at J-PARC/MLF/ANNRI and KURRI/LINAC facilities. Effectiveness of combining the independent techniques has been demonstrated for identifying bias effects and improving accuracy, especially in characterization of samples used for nuclear data measurements. Capture cross sections and/or total cross sections have been measured for Am-241, Am-243, Np-237, Tc-99, Gd-155, and Gd-157. Systematic nuclear data evaluation has also been performed by taking into account the identified bias effect. Highlights of the AIMAC project are outlined

Spontaneous Regression of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

An 83-year-old man underwent transcatheter arterial chemoembolization (TACE) for a 20-mm hepatocellular carcinoma (HCC) in Couinaud’s segment 4. Computed tomography (CT) 4 months after TACE showed tumor thrombus in the portal vein in addition to diffuse metastases and arterioportal shunts in the left lobe. Although we performed the best supportive care, the tumor thrombus in the portal vein and tumors in the left lobe had completely disappeared on CT 16 months after the TACE. Rapidly grown portal vein tumor thrombus and arterioportal shunt might be the causes of spontaneous regression of HCC, probably associated with tumor hypoxia