継承語年少学習者と第二言語学習者 : ロシア語教育の方法

<p>(G1) (Normal control group); (G2) (Ulcer control group); (G3) (Omeprazole); (G4) (62.5 mg/kg), (G5) (125 mg/kg), (G6) (250 mg/kg) and (G7) (500 mg/kg) of <i>V</i>. <i>pubescens</i> extract. HSP70 protein was over-expressed in rats pre-treated with omeprazole or <i>V</i>. <i>pubescens</i> extract (brown color shows over-expression of HSP70 protein) (magnification 20×). There were 6 rats in each group of experiment. The Image J program was used to evaluate protein expression. All values are expressed as the means ± the standard error of mean. The mean difference was significant at the <i>p < 0</i>.<i>05</i> level compared to the cancer control group.</p

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家族看護学が看護の専門領域として確立され発展していくため,今後の研究の方向性を明らかにしたいと,国内外の家族および家族看護学に関する文献の数量的動向と研究領域別文献概観を行った結果,国内外ともに家族,家族の健康,家族援助に関する研究報告は増加傾向にあり,家族への関心の高まりと実践上の必要性が反映されていた。また,わが国では高齢化社会における家族援助の要求が家族看護学の確立を促していること,今後は家族を対象とした評価方法の開発や援助に関する予防的・実践的研究が求められていることが示唆された。The review of the literature on family nursing through numerical trend and research fields was done to know how to establish and develop nursing specialty in this area. The followings were suggested. 1) The researches concerning family, family health, and family practice were increasing in both inside and outside of Japan. 2) ln U. S. A., family nursing was developed in the field of maternal-child and psychiatric nursing, introducing family system theory. In Japan family nursing is rather essential in the field of home care for the aeed, due to aging population. 3) Further researches on development of assessment tool, intervention and social support are necessary, especially by preventive and practical points of view

Heterometallic Pd^II–Ni^II Complexes with <i>meso</i>-Substituted Dibenzotetraaza[14]annulene: Double C–H Bond Activation and Formation of a Rectangular Tetradibenzotetraaza[14]annulene

Three isomeric 2­[Pd^II–Ni^II] metal complexes, derived from indoleninyl <i>meso</i>-substituted dibenzotetraaza[14]­annulene, were synthesized. The resulting dimers feature Ni···Ni or, alternatively, Ni···π interactions in staggered or slipped cofacial structures. A remarkable insertion of palladium into two different C–H bonds yielded a 4­[Pd^II–Ni^II] rectangular complex with dimensions of 8.73 × 10.38 Å

Indolenine <i>meso</i>-Substituted Dibenzotetraaza[14]annulene and Its Coordination Chemistry toward the Transition Metal Ions Mn^III, Fe^III, Co^II, Ni^II, Cu^II, and Pd^II

A new dibenzotetraaza[14]­annulene bearing two 3,3-dimethylindolenine fragments at the <i>meso</i> positions (<b>L</b>H₂), has been synthesized through a nontemplate method. X-ray crystallography shows that the whole molecule is planar. The basicity of the indolenine ring permits the macrocycle to be protonated external to the core and form <b>L</b>H₄²⁺·2Cl^–. Yet another structural modification having strong C–H···π interactions was found in the chloroform solvate of <b>L</b>H₂. The latter two modifications are accompanied by a degree of nonplanar distortion. The antiaromatic core of the macrocycle can accommodate a number of metal ions, Mn^III, Fe^III, Co^II, Ni^II and Cu^II, to form complexes of [Mn­(<b>L</b>)­Br], [Mn­(<b>L</b>)­Cl], [Fe­(<b>L</b>H₂)­Cl₂]⁺·Cl^–, [Co­(<b>L</b>)], [Ni­(<b>L</b>)], and [Cu­(<b>L</b>)]. In addition, the reaction of <b>L</b>H₂ with the larger Pd^II ion leads to the formation of [Pd₂(<b>L</b>H₂)₂(OAc)₄] wherein the macrocycle acts as a semiflexible ditopic ligand to coordinate pairs of metal ions <i>via</i> its indolenine N atoms into dinuclear metallocycles. The compounds <b>L</b>H₂, [Co­(<b>L</b>)], and [Ni­(<b>L</b>)] are isostructural and feature close π-stacking as well as linear chain arrangements in the case of the metal complexes. Variable temperature magnetic susceptibility measurements showed thermally induced paramagnetism in [Ni­(<b>L</b>)]

Indolenine <i>meso</i>-Substituted Dibenzotetraaza[14]annulene and Its Coordination Chemistry toward the Transition Metal Ions Mn^III, Fe^III, Co^II, Ni^II, Cu^II, and Pd^II

A new dibenzotetraaza[14]­annulene bearing two 3,3-dimethylindolenine fragments at the <i>meso</i> positions (<b>L</b>H₂), has been synthesized through a nontemplate method. X-ray crystallography shows that the whole molecule is planar. The basicity of the indolenine ring permits the macrocycle to be protonated external to the core and form <b>L</b>H₄²⁺·2Cl^–. Yet another structural modification having strong C–H···π interactions was found in the chloroform solvate of <b>L</b>H₂. The latter two modifications are accompanied by a degree of nonplanar distortion. The antiaromatic core of the macrocycle can accommodate a number of metal ions, Mn^III, Fe^III, Co^II, Ni^II and Cu^II, to form complexes of [Mn­(<b>L</b>)­Br], [Mn­(<b>L</b>)­Cl], [Fe­(<b>L</b>H₂)­Cl₂]⁺·Cl^–, [Co­(<b>L</b>)], [Ni­(<b>L</b>)], and [Cu­(<b>L</b>)]. In addition, the reaction of <b>L</b>H₂ with the larger Pd^II ion leads to the formation of [Pd₂(<b>L</b>H₂)₂(OAc)₄] wherein the macrocycle acts as a semiflexible ditopic ligand to coordinate pairs of metal ions <i>via</i> its indolenine N atoms into dinuclear metallocycles. The compounds <b>L</b>H₂, [Co­(<b>L</b>)], and [Ni­(<b>L</b>)] are isostructural and feature close π-stacking as well as linear chain arrangements in the case of the metal complexes. Variable temperature magnetic susceptibility measurements showed thermally induced paramagnetism in [Ni­(<b>L</b>)]

Chemical structure of artonin E.

<p>Chemical structure of artonin E.</p

Effect of artonin E on caspases activation.

<p>(A) Relative expression levels of caspases- 3, -8, and -9 in SKOV-3 cells treated with 8 μg/mL of artonin E for 24, 48, and 72 h. Results are represented as mean±SD of three replicates. *<i>p<</i>0.05 indicates significant difference from control. (B) Time-dependent of protein expression levels of caspase-3, -8 and -9 in SKOV-3 cells treated with 8 μg/mL of artonin E. Artonin E induced the up-regulation of caspase-9, -3 and -8. (C) The quantitative analysis is expressed as a ratio to the expression of β-actin. The data are represented as mean±SD of three replicates. *<i>p<</i>0.05 indicates significant difference from control.</p

MTT assay of artonin E on various cell lines.

<p>MTT assay of artonin E on various cell lines.</p

Effects of Artonin E on ROS generation in SKOV-3 cells.

<p>Cells were treated with 8 μg/mL of artonin E for 24, 48, and 72 h. Values are expressed as mean±SD from three independent experiments. Statistical significance was expressed as <i>*p<0</i>.<i>05</i>.</p

Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells - Fig 10

<p>(A) Effect of artonin E (8 μg/mL) on the mitochondrial and cytosolic cytochrome c fractions after 24, 48, and 72 h. β-Actin was used as loading control. (B) Quantitative analysis of SKOV-3 cells treated with artonin E. All data were expressed as mean±SD. Statistical significance was expressed as *<i>p<</i>0.05. </p