Additional file 1 of Osimertinib in combination with anti-angiogenesis therapy presents a promising option for osimertinib-resistant non-small cell lung cancer

Additional file 1: Table S1. COX regression analysis by baseline. Table S2. Univariate Cox regression analysis by baseline characteristics for OS. Table S3. Antibodies for panel A for T cells. Table S4. Antibodies for panel A for macrophages and MDSC

Structural and Electrochemical Characteristics of Ca-Doped “Flower-like” Li₄Ti₅O₁₂ Motifs as High-Rate Anode Materials for Lithium-Ion Batteries

Doped motifs offer an intriguing structural pathway toward improving conductivity for battery applications. Specifically, Ca-doped, three-dimensional “flower-like” Li_4–<i>x</i>Ca_<i>x</i>Ti₅O₁₂ (“<i>x</i>” = 0, 0.1, 0.15, and 0.2) micrometer-scale spheres have been successfully prepared for the first time using a simple and reproducible hydrothermal reaction followed by a short calcination process. The products were experimentally characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) mapping, inductively coupled plasma optical emission spectrometry (ICP-OES), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and galvanostatic charge–discharge testing. Calcium dopant ions were shown to be uniformly distributed within the LTO structure without altering the underlying “flower-like” morphology. The largest lattice expansion and the highest Ti³⁺ ratios were noted with XRD and XPS, respectively, whereas increased charge transfer conductivity and decreased Li⁺-ion diffusion coefficients were displayed in EIS for the Li_4–<i>x</i>Ca_<i>x</i>Ti₅O₁₂ (“<i>x</i>” = 0.2) sample. The “<i>x</i>” = 0.2 sample yielded a higher rate capability, an excellent reversibility, and a superior cycling stability, delivering 151 and 143 mAh/g under discharge rates of 20C and 40C at cycles 60 and 70, respectively. In addition, a high cycling stability was demonstrated with a capacity retention of 92% after 300 cycles at a very high discharge rate of 20C. In addition, first-principles calculations based on density functional theory (DFT) were conducted with the goal of further elucidating and understanding the nature of the doping mechanism in this study. The DFT calculations not only determined the structure of the Ca-doped Li₄Ti₅O₁₂, which was found to be in accordance with the experimentally measured XPD pattern, but also yielded valuable insights into the doping-induced effect on both the atomic and electronic structures of Li₄Ti₅O₁₂