1 research outputs found
Levels of Blood Organophosphorus Flame Retardants and Association with Changes in Human Sphingolipid Homeostasis
While
a recent toxicological study has shown that organophosphorus
flame retardants (OPFRs) may disrupt sphingolipid homeostasis, epidemiologic
evidence is currently lacking. In this study, a total of 257 participants
were recruited from Shenzhen, China. Eleven OPFRs were for the first
time simultaneously determined in the human blood samples by ultraperformance
liquid chromatography and tandem mass spectrometry. Six OPFRs, tributyl
phosphate (TNBP), 2-ethylhexyl diphenyl phosphate (EHDPP), trisÂ(2-chloroisopropyl)
phosphate (TCIPP), trisÂ(2-butoxyethyl) phosphate (TBOEP), triethyl
phosphate (TEP), and TPHP, were detectable in at least 90% of participants,
with median concentrations of 37.8, 1.22, 0.71, 0.54, 0.49, and 0.43
ng/mL, respectively. Sphingomyelin (SM) levels in the highest quartile
of EHDPP, TPHP, TNBP, TBOEP, TEP, and TCIPP were 45.3% [95% confidence
interval; 38.1%, 53.0%], 51.9% (45.5%, 58.6%), 153.6% (145.1%, 162.3%),
20.6% (14.5%, 27.0%), 59.0% (52.1%, 66.2%), and 62.8% (55.2%, 70.6%)
higher than those in the lowest quartile, respectively, after adjusting
for covariates. Sphingosine 1-phosphate (S1P) levels in the highest
quartile of EHDPP, TPHP, and TNBP were 36% (−39%, −33%),
16% (−19%, −14%), and 36% (−38%, −33%)
lower than those in the lowest quartile, respectively. A similar pattern
emerged when exposures were modeled continuously. We for the first
time found the associations between OPFRs and changes in human sphingolipid
homeostasis