1 research outputs found
Stimulus-Responsive Metal–Organic Framework Signal-Reporting System for Photoelectrochemical and Fluorescent Dual-Mode Detection of ATP
Dual-mode bioanalysis integrating photoelectrochemical
(PEC) and
other modes is emerging and allows signal cross-checking for more
reliable results. Metal–organic frameworks (MOFs) have been
shown to be attractive materials in various biological applications.
This work presents the utilization of MOF encapsulation and stimuli-responsive
decapsulation for dual-mode PEC and fluorescence (FL) bioanalysis.
Photoactive dye methylene violet (MV) was encapsulated in zeolitic
imidazolate framework-90 (ZIF-90) to form an MV@ZIF-90 hybrid material,
and MV could be released by adenosine triphosphate (ATP)-induced ZIF-90
disintegration. The released MV not only had FL emission but also
had a sensitization effect on the ZnIn2S4 (ZnInS)
photoanode. Based on the MV-dependent sensitization effect and FL
emission characteristic, a dual-mode PEC–FL strategy was established
for ATP detection with low detection limits, that is, 3.2 and 4.1
pM for PEC and FL detection, respectively. This study features and
will inspire the construction and implementation of smart MOF materials
for dual-mode bioanalysis