Prevention and Treatment of Cardiac Surgery Associated Acute Kidney Injury.

AIM OF REVIEW: Acute kidney injury (AKI) after cardiac surgery is a relatively common postoperative complication and is independently related to increased mortality and morbidity. METHOD: In this review, we will focus on risk factors of developing AKI, early detection by biomarkers and preventive strategies for AKI after adult cardiac surgery. RECENT FINDINGS: Many perioperative factors affect renal function and acute AKI following cardiac surgery. Novel biomarkers of kidney injury such as neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), cystatin C (CysC), have the potential to facilitate the early diagnosis of cardiac surgery associated AKI (CSA-AKI). Pharmacological interventions have been inconsistent to their efficacy, and to date, there is no compelling pharmacologic agent known to reduce the risk of AKI or treat established AKI. SUMMARY: Preventive strategies of AKI focus on optimal perioperative management

Development of Low-cost Drifters Array for Nearshore Current Mapping in Coastal Groin Effect Basins

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

FuXi: A cascade machine learning forecasting system for 15-day global weather forecast

Over the past few years, due to the rapid development of machine learning (ML) models for weather forecasting, state-of-the-art ML models have shown superior performance compared to the European Centre for Medium-Range Weather Forecasts (ECMWF)'s high-resolution forecast (HRES) in 10-day forecasts at a spatial resolution of 0.25 degree. However, the challenge remains to perform comparably to the ECMWF ensemble mean (EM) in 15-day forecasts. Previous studies have demonstrated the importance of mitigating the accumulation of forecast errors for effective long-term forecasts. Despite numerous efforts to reduce accumulation errors, including autoregressive multi-time step loss, using a single model is found to be insufficient to achieve optimal performance in both short and long lead times. Therefore, we present FuXi, a cascaded ML weather forecasting system that provides 15-day global forecasts with a temporal resolution of 6 hours and a spatial resolution of 0.25 degree. FuXi is developed using 39 years of the ECMWF ERA5 reanalysis dataset. The performance evaluation, based on latitude-weighted root mean square error (RMSE) and anomaly correlation coefficient (ACC), demonstrates that FuXi has comparable forecast performance to ECMWF EM in 15-day forecasts, making FuXi the first ML-based weather forecasting system to accomplish this achievement

Where do they come from? Identification of globular cluster escaped stars

Globular clusters (GCs), as old as our Galaxy, constantly lose their members to the field as they cross through the Milky Way (MW). These GC escaped stars (or escapees) are suggested to contribute significantly to the MW halo. If a star has left the host GC a long time ago, chemical finger prints, e.g., N enrichment, may reveal its origin. In this work, we aim to establish dynamical connections between N-rich field stars recently identified by LAMOST and the existing MW GCs. By constructing the full action distribution, and combining with metallicity, we found 29 potential GC progenitors for 15 N-rich field stars. Particularly, some of them may be related to MW accretion events. On the other hand, if a star recently left its host GC via tidal evaporation, it still maintain the kinematic properties of the cluster. Here we identify extra-tidal candidates based on their spatial locations, proper motions (PMs), and their position on color-magnitude-diagrams (CMDs). We successfully identified more than 1600 extra-tidal candidates in the vicinity of six Gaia-Enceladus (GE)-related GCs (i.e., NGC 1851, NGC 1904, NGC 6205, NGC 6341, NGC 6779, NGC 7089). The density map of the extra-tidal candidates is confirmed to be an efficient way to find extra-tidal structures. The possible two density peaks at opposite directions of the inner boundary is a good indicator for long stellar stream. Among 95 extra-tidal candidates with spectroscopic radial velocities and metallicity, 54 of them are confirmed to be GC escaped stars, as they share similar properties as host GCs. These extra-tidal candidates are ideal targets for follow-up spectroscopic observation, as it greatly improves the scientific outcome. Once statistically significant number of spectroscopic radial velocities and metallicities are available, the GC dynamical evolution (e.g., mass loss, rotation) can be carefully investigated.Comment: 14 pages, 12 figures. Accepted by A&

Study on Effects of Titanium Surface Microporous Coatings Containing Zinc on Osteoblast Adhesion and Its Antibacterial Activity

Metal surface structure/biomedical function integration is the current research focus. In previous studies, we have successfully prepared the microporous coatings containing zinc on the pure titanium surface by MAO. In the study, osteoblasts were seeded on the surface of the microporous coatings containing zinc and the adhesion of osteoblasts were evaluated, and the antibacterial activity of the microporous coatings containing zinc is observed through in vitro bacterial experiments. The result indicates that the adhesion ability of osteoblasts on the surface of microporous coatings containing zinc was very good, and the coatings could obviously inhibit the growth of Staphylococcus aureus and had good antibacterial activity. In conclusion, the microporous coatings containing zinc on titanium surface have good osteogenic and antibacterial properties and have good application prospect

Geochemistry and geochronology of dolerite dykes from the Daba and Dongbo peridotite massifs, SW Tibet: Insights into the style of mantle melting at the onset of Neo-Tethyan subduction

This study reports compositional and whole-rock Sr-Nd isotope data as well as zircon U-Pb geochronological data on dolerite dikes from the Daba and Dongbo ultramafic massifs, southwest Yarlung-Zangbo Suture Zone (YZSZ), Tibet. The 120.6 \ub1 1.6 Ma dolerite dikes from the Daba peridotite exhibit normal mid-ocean ridge basalt (N-MORB)-type normalized mutli-element patterns [(La/Yb)N = 0.43-0.72] with noticeable negative Nb and Th anomalies. They have high initial 87Sr/8624 Sr ratios (87Sr/8625 Sr(i) = 0.70720-0.70788) and high \u3b5Nd(t) values (+7.4 to +7.9). The 125.4 \ub1 1.8 Ma dolerite intrusions within the Dongbo peridotite show N-MORB\u2012type trace element profiles [(La/Yb)N = 0.65-0.84] characterized by apparent negative anomalies in Nb and Th, and mild negative anomalies in Ti (\ub1 Y). They also have high 87Sr/8629 Sr(i) ratios (0.70611-0.70679) and elevated \u3b5Nd(t) values (+7.8 to +8.2). Semi-quantitative La/Yb vs. Dy/Yb modeling demonstrates that the parental magmas of the investigated dolerite dikes derived from more than 20% (cumulative) melting of a (broad) mantle source region that had a spinel-bearing N-MORB\u2013like lherzolitic composition. Our geochemical and isotopic data indicate that the composition of the inferred mantle source was influenced by minor input of subducted crustal material. The petrogenesis of the Daba and Dongbo massifs could be linked to upwelling of an asthenospheric source that caused continental rift and subsequent seafloor spreading, followed by subduction initiation adjacent to a passive margin during the early Cretaceous (~130-120 Ma). Our study provides a more detailed, and perhaps more elegant, hypothesis for the tectono-magmatic evolution of the southwestern YZSZ "ophiolitic" peridotites after their accretion beneath a Neo-Tethyan marginal basin