Shows the receiver operating curve analysis of the LightCycler SeptiFast molecular diagnostic method for the detection of bacterial and fungal infection (Figure 1.1), bacterial infection alone (Figure 1.2), and fungal infection alone (Figure 1.3).

<p>Solid line, solid square, inner dashed line and outer dotted line represents hierarchical summary receiver operating characteristic (HSROC) curve, bivariate summary estimate, 95% confidence ellipse, and 95% prediction ellipse. Symbol area is proportional to study size.</p

Summary of the subgroup analysis of the 34 included studies.

<p>AUROC = area under receiver operating characteristic curve. OR = odds ratio. CDI = clinically documented infection. ICU = intensive care unit.</p

Shows forest plot of the diagnostic odds ratios of studies using the LightCycler SeptiFast diagnostic method to detect bacterial and fungal infection (Figure 2.1), bacterial infection alone (Figure 2.2), and fungal infection alone (Figure 2.3).

<p>Shows forest plot of the diagnostic odds ratios of studies using the LightCycler SeptiFast diagnostic method to detect bacterial and fungal infection (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062323#pone-0062323-g002" target="_blank">Figure 2</a>.1), bacterial infection alone (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062323#pone-0062323-g002" target="_blank">Figure 2</a>.2), and fungal infection alone (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062323#pone-0062323-g002" target="_blank">Figure 2</a>.3).</p

Characteristics of the 34 included studies.

<p>NA =  non-available. ED = Emergency Department. ICU = Intensive Care Unit. CDI = clinically documented infection. LDI = laboratory-documented infection. BC = blood culture. Sen. = sensitivity. Spe. = specificity.</p

Exploration of heterogeneity in assessment of accuracy of LightCycler SeptiFast test for diagnosis of bacteremia or fungemia.

<p>Exploration of heterogeneity in assessment of accuracy of LightCycler SeptiFast test for diagnosis of bacteremia or fungemia.</p