Application of Zebrafish Models in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, recurrent, and remitting inflammatory disease with unclear etiology. As a clinically frequent disease, it can affect individuals throughout their lives, with multiple complications. Unfortunately, traditional murine models are not efficient for the further study of IBD. Thus, effective and convenient animal models are needed. Zebrafish have been used as model organisms to investigate IBD because of their suggested highly genetic similarity to humans and their superiority as laboratory models. The zebrafish model has been used to study the composition of intestinal microbiota, novel genes, and therapeutic approaches. The pathogenesis of IBD is still unclear and many risk factors remain unidentified. In this review, we compare traditional murine models and zebrafish models in terms of advantages, pathogenesis, and drug discovery screening for IBD. We also review the progress and deficiencies of the zebrafish model for scientific applications

The prevalence and factors for cancer screening behavior among people with severe mental illness in Hong Kong

Objectives: Screening is useful in reducing cancer incidence and mortality. People with severe mental illness (PSMI) are vulnerable to cancer as they are exposed to higher levels of cancer risks. Little is known about PSMI's cancer screening behavior and associated factors. The present study examined the utilization of breast, cervical, prostate, and colorectal cancer screening among PSMI in Hong Kong and to identify factors associated with their screening behaviors. Method: 591 PSMI from community mental health services completed a cross-sectional survey. Results: The percentage of cancer screening behavior among those who met the criteria for particular screening recommendation was as follows: 20.8% for mammography; 36.5% for clinical breast examination (CBE); 40.5% for pap-smear test; 12.8% for prostate examination; and 21.6% for colorectal cancer screening. Results from logistic regression analyses showed that marital status was a significant factor for mammography, CBE, and pap-smear test; belief that cancer can be healed if found early was a significant factor for pap-smear test and colorectal screening; belief that one can have cancer without having symptoms was a significant factor for CBE and pap-smear test; belief that one will have a higher risk if a family member has had cancer was a significant factor for CBE; and self-efficacy was a significant factor for CBE and papsmear test behavior. Conclusions: Cancer screening utilization among PSMI in Hong Kong is low. Beliefs about cancer and self-efficacy are associated with cancer screening behavior. Health care professionals should improve the knowledge and remove the misconceptions about cancer among PSMI; self-efficacy should also be promoted

Augmenting Buried In Treasures With In-Home Uncluttering Practice: Pilot Study In Hoarding Disorder

Hoarding disorder is characterized by difficulty parting with possessions and by clutter that impairs the functionality of living spaces. Cognitive behavioral therapy conducted by a therapist (individual or in a group) for hoarding symptoms has shown promise. For those who cannot afford or access the services of a therapist, one alternative is an evidence-based, highly structured, short-term, skills-based group using CBT principles but led by non-professional facilitators (the Buried in Treasures [BIT] Workshop). BIT has achieved improvement rates similar to those of psychologist-led CBT. Regardless of modality, however, clinically relevant symptoms remain after treatment, and new approaches to augment existing treatments are needed. Based on two recent studies - one reporting that personalized care and accountability made treatments more acceptable to individuals with hoarding disorder and another reporting that greater number of home sessions were associated with better clinical outcomes, we tested the feasibility and effectiveness of adding personalized, in-home uncluttering sessions to the final weeks of BIT. Participants (n = 5) had 15 sessions of BIT and up to 20 hours of in-home uncluttering. Reductions in hoarding symptoms, clutter, and impairment of daily activities were observed. Treatment response rate was comparable to rates in other BIT studies, with continued improvement in clutter level after in-home uncluttering sessions. This small study suggests that adding in-home uncluttering sessions to BIT is feasible and effective

Temporal Shift Module with Pretrained Representations for Speech Emotion Recognition

Recent advances in self-supervised models have led to effective pretrained speech representations in downstream speech emotion recognition tasks. However, previous research has primarily focused on exploiting pretrained representations by simply adding a linear head on top of the pretrained model, while overlooking the design of the downstream network. In this paper, we propose a temporal shift module with pretrained representations to integrate channel-wise information without introducing additional parameters or floating-point operations per second. By incorporating the temporal shift module, we developed corresponding shift variants for 3 baseline building blocks: ShiftCNN, ShiftLSTM, and Shiftformer. Furthermore, we propose 2 technical strategies, placement and proportion of shift, to balance the trade-off between mingling and misalignment. Our family of temporal shift models outperforms state-of-the-art methods on the benchmark Interactive Emotional Dyadic Motion Capture dataset in fine-tuning and feature-extraction scenarios. In addition, through comprehensive experiments using wav2vec 2.0 and Hidden-Unit Bidirectional Encoder Representations from Transformers representations, we identified the behavior of the temporal shift module in downstream models, which may serve as an empirical guideline for future exploration of channel-wise shift and downstream network design

Compulsively seeking certainty: Clarifying the association between intolerance of uncertainty and compulsion severity in OCD

Intolerance of uncertainty (IU), the dispositional tendency to fear the unknown, has clinical implications across a variety of disorders. While research has linked IU and OCD, relatively little is known about this association. Previous studies have focused on IU’s association with overall OCD severity and specific symptom dimensions, but we do not yet understand to what degree this cognitive vulnerability is associated with each of the two cardinal symptoms: obsessions and compulsions. Additionally, few studies have examined the established IU subtypes—prospective and inhibitory IU—as unique contributors to OCD severity. Given the ubiquity of uncertainty in daily life and the potential for IU to influence obsessive-compulsive processes, further investigation of this cognitive vulnerability in OCD is warranted. In a sample of patients diagnosed with OCD, partial correlations were conducted to determine the association between OCD severity (separately examining obsessions and compulsions) and IU (separately examining prospective and inhibitory IU). These analyses revealed positive correlations between IU and compulsion severity, specifically. And of the IU subtypes, this link was specifically associated with prospective IU. The results of this correlational study contribute to the literature on IU in OCD, suggesting prospective IU as a cognitive mechanism that may be involved in the maintenance of compulsions

High-arousal positive emotion evoking is more effective in VR than on a 2D monitor based on computational affection

Virtual Reality (VR) technology has been widely used in researching situations that require high ecological validity but are difficult to copy. In this paper, we compare the effect of 360-degree videos in VR head-mounted display and 2D computer screen on evoking four types of emotional states, and innovatively assess the effect of emotion evoking using the Go/No-go attention paradigm. Based on the eye movement data collected from a considerable number of participants (N=48), the result reaches marginally significance in the effect of immersion level of evoking (p=0.075), emotion’s level of arousal (p=0.019), and the interaction between them (p=0.037) under the condition of positive evoking. We find that immersive device can better evoke positive emotions with high arousal, while non-immersive device cannot manipulate the intensity of evoked emotions. Our study empirically demonstrate that high-arousal positive emotion evoking is more effective in VR than on a 2D monitor based on computational affection