15 research outputs found
Precise automated determination of the total and segmented right ventricular volumes for functional studies of the right ventricle using CMR
Interventional creation of an atrial septal defect and its impact on right ventricular function: An animal study with the pressure-volume conductance system
Background: The aim of our study was to assess the suitability of different interventional
techniques to create an atrial septal defect (ASD) and to evaluate the short-term effects of right
ventricular (RV) volume overload on RV contractility in the growing swine.
Methods: Thirteen ASD and six control animals were studied. An ASD was created by
balloon dilatation (BD) of the fossa ovalis (n = 4) or by implantation of a multi-perforated
Amplatzer Septal Occluder (n = 4) or a patch-less nitinol device (n = 5). After 4.8 (3.9–6.0)
weeks, the amounts of left-to-right shunting (Qp/Qs) and RV contractility (end systolic elastance
— Ees) were assessed.
Results: In the ASD group, a significant left-to-right shunt could be documented (Qp/Qs 1.5 ±
± 0.4). However, a shunt was absent in the BD subgroup (Qp/Qs 1.1 ± 0.1). In animals with
devices implanted, a significant relationship between the post-mortem ASD area and Qp/Qs
was found (r = 0.68, p < 0.05). Compared to controls, RV contractility was not significantly
impaired at rest and during dobutamine in ASD animals (Ees: 0.40 ± 0.20 vs 0.54 ± 0.12
and 0.75 ± 0.29 vs 1.04 ± 0.24 mm Hg/mL, p = NS for both).
Conclusions: Device implantation is necessary to create a patent ASD resulting in significant
left-to-right shunting. In an experimental ASD model, a five week period of chronic RV
volume overload does not alter RV contractility significantly. (Cardiol J 2011; 18, 3: 289–296
Assessment of intraatrial lateral tunnel anatomy and venous blood flow in children with hypoplastic left heart syndrome in Fontan circulation
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Method for a detailed evaluation of respiratory cardiac contributions to blood flow in Fontan circulation
Congenital heart defect specific volumetric data in children with Hypoplastic Left Heart Syndrome measured by CMR
Impairment of aortic elastic properties in patients with transposition of the great arteries post arterial switch operation
Impairment of aortic elastic properties in patients with transposition of the great arteries post arterial switch operation
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