Rækkedyrkning fortjener at blive videreudviklet

Korndyrkning på rækker med efterafgrøder i rækkemellemrummene, der efter høst radrenses, så der kan etableres korn igen uden pløjning, kan blive et decideret paradigmeskifte inden for økologisk dyrkning. Det er det ikke endnu, men metoden fortjener at blive videreudviklet. På Barritskov er rækkedyrkning nu en fast del af markplanen, om end vi ikke rækkedyrker i alle afgrøder

Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study

Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP, were obtained from 5,765 individuals attending a population-based cohort study. We followed up participants from inclusion in the fourth survey of the Tromsø Study (1994/1995) until December 31, 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI: 1.14–1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI: 1.20–2.24) compared with subjects in the lowest quintile. RDW mediated 7.2% (95% CI: 4.0–30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI: 0.98–1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI: 1.06–1.97) compared with subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD

EFFORT study:Comparing impact of operation and assisted reproductive technologies on fertility for women with deep infiltrating endometriosis - study protocol for a multicentre randomised trial

INTRODUCTION: Deep infiltrating endometriosis (DIE) affecting the rectum or sigmoid colon is associated with infertility, severe pain and decreased quality of life. As most women with DIE are young, many have a pregnancy intention. Treatment possibilities of endometriosis-associated infertility are surgery or assisted reproductive technologies (ART). However, no studies have compared the two interventions directly. Therefore, this study aims to determine the cumulative pregnancy rate (CPR) and the live birth rate (LBR) after first-line surgery compared with first-line ART for women with rectosigmoid DIE and a pregnancy intention. METHODS AND ANALYSIS: Multicentre, parallel-group, randomised trial of women with rectosigmoid DIE and a pregnancy intention for at least 6 months in Aarhus, Denmark and Bordeaux, France. 352 women aged 18–38 years are randomised 1:1 to either surgical management (shaving, disc excision or segmental resection) or ART management (at least two in vitro fertilisation or intracytoplasmic sperm injection procedures if not pregnant after the first cycle). Women in the surgical intervention group will attempt to get pregnant by either spontaneous conception or ART, depending on the endometriosis fertility index score. Primary outcome measures are CPR and LBR at 18 months’ follow-up. Secondary outcomes are: Non-viable pregnancies, time to pregnancy, pain score, quality of life, complication rate, bowel and bladder function, endocrine and inflammatory profile, number of oocytes, blastocysts, frozen embryos and blastocyst morphology score within 18 months after either intervention. ETHICS AND DISSEMINATION: Conduct of this study is approved by the Danish National Committee on Health Research Ethics and Comité de Protection des Personnes Ile de France VIII. Study participants must sign an informed consent form. The results will be presented at national and international conferences and published in international peer-reviewed journals. TRIAL REGISTRATION NUMBER: This trial is registered at ClinicalTrials.gov (no. NCT04610710). PROTOCOL VERSION: The Danish National Committee on Health Research Ethics: Fifth protocol version approved 7 September 2020 (no. 1-10-72-96-20). Comité de Protection des Personnes Ile de France VIII: Version 1.1 22JAN2021 the 9 March 2021

A Phase I/II Clinical Trial of Belinostat (PXD101) in Combination with Doxorubicin in Patients with Soft Tissue Sarcomas

Background. Belinostat is a novel histone deacetylase inhibitor. Primary Objectives. Maximum tolerated dose (MTD) and dose limiting toxicities (DLTs) of belinostat (Bel) in combination with doxorubicin (Dox) in solid tumours (phase I) and response rate (RR) in soft tissue sarcomas (phase II). Methods. Bel was administered as a 30-minute IV infusion on days 1–5 and on day 5 with Dox. The dose escalation schedule was as follows: cohort 1: Bel 600 mg/m2 and 50 mg/m2 Dox, cohort 2: Bel 600 mg/m2 and 75 mg/m2 Dox, cohort 3: Bel 800 mg/m2 and 75 mg/m2 Dox, and cohort 4: Bel 1000 mg/m2 and 75 mg/m2 Dox. Results. 41 patients were included (25 in phase I, 16 in phase II). Adverse events were fatigue (95%), nausea (76%), and alopecia (63%). There was one DLT, grade 3 rash/hand and foot syndrome. MTD was Bel 1000 mg/m2/d and Dox 75 mg/m2. Four responses were seen: 2 PR in phase I, RR of 8%; in phase II, 1 PR/1 CR, RR of 13%, and 9 patients (56%) with SD. Conclusion. The combination was well tolerated. Response rate was moderate but median time to progression was 6.0 months (95% CI, 1.6–9.7 months) which is superior to some reports of single-agent Dox

Želimo li biti uključeni? Promicanje turizma i industrijske baštine Nijemaca u Vojvodini

Local community members are considered as one of key stakeholder groups for sustainable tourism development, not only as service providers, but also as an important part of a decision-making process in tourism development. In respect to that, this study was focused on their perceptions of potential tourism activities based on resources that are still not valued for the purpose of tourism. There is a question whether the local community members want to be involved and whether they perceive the industrial heritage as beneficial for the local development. The research was conducted on the example of the industrial heritage in Vojvodina (Autonomous Province in Serbia, former part of the Austro-Hungarian Empire), characterized by its historical, cultural, technical, architectural, and educational values of the industrial heritage of Germans as a national minority. The survey research based on the 44- item SUS TAS scale was conducted on a sample of 300 respondents, between October 2021 and March 2022. The main findings highlight the positive attitudes of the local community members on sustainable development of the industrial heritage, but also their insufficient knowledge of values in terms of German industrial legacy within their local environment. The research results may contribute to experts in the field of tourism and culture for domestic and international tourism development.Članovi lokalne zajednice smatraju se jednim od ključnih skupina dionika za razvoj održivoga turizma, ne samo kao pružatelji usluga, nego i kao važan segment procesa donošenja odluka u razvoju turizma. U skladu s time ovo se istraživanje usmjerilo na njihove percepcije potencijalnih turističkih aktivnosti temeljem resursa koji se još uvijek ne vrednuju u turističke svrhe. Nameće se pitanje žele li se članovi lokalne zajednice uključiti te percipiraju li industrijsku baštinu kao pogodnu za lokalni razvoj. Istraživanje je provedeno na uzorku industrijske baštine u Vojvodini (autonomna pokrajina u Srbiji, ranije dio Austro-Ugarskog Carstva), obilježene povijesnim, kulturnim, tehničkim, arhitektonskim i obrazovnim vrijednostima industrijske baštine Nijemaca kao nacionalne manjine. Istraživanje temeljeno na skali SUS TAS sastavljenoj od 44 čestice provedeno je na uzorku od 300 ispitanika između listopada 2021. i ožujka 2022. godine. Kao glavni nalazi ističu se pozitivni stavovi članova lokalne zajednice o održivom razvoju industrijske baštine, ali i njihovo nedovoljno znanje o vrijednostima u smislu njemačkog industrijskog nasljeđa unutar lokalne sredine. Rezultati istraživanja mogli bi koristiti stručnjacima u polju turizma i kulture za razvoj domaćeg i međunarodnog turizma

University Campus Living Labs

Universities and their changing role in society is a source of perennial debate. In this article, we examine the emergent phenomenon of University Campus Living Labs (UCLL), the set of practices by which universities use their own buildings, streets or energy infrastructure as experimental settings in order to support applied teaching, research and co-creation with society. While most existing studies of UCLLs focus on them as sustainability instruments, we explore the UCLL phenomenon from an open-ended and fresh angle. Using living labs in five European universities as exemplary cases, we demonstrate the breadth and variability of this emerging phenomenon through five analytical dimensions to unpack the multiple forms and purposes that UCLLs can have. We furthermore consider aspects of inclusiveness and situatedness of living lab co-creation and testing and what the UCLL phenomena may come to mean for the continuously changing university, calling for future studies to substantiate these aspects

Towards representing human behavior and decision making in Earth system models. An overview of techniques and approaches

Today, humans have a critical impact on the Earth system and vice versa, which can generate complex feedback processes between social and ecological dynamics. Integrating human behavior into formal Earth system models (ESMs), however, requires crucial modeling assumptions about actors and their goals, behavioral options, and decision rules, as well as modeling decisions regarding human social interactions and the aggregation of individuals’ behavior. Here, we review existing modeling approaches and techniques from various disciplines and schools of thought dealing with human behavior at different levels of decision making. We demonstrate modelers’ often vast degrees of freedom but also seek to make modelers aware of the often crucial consequences of seemingly innocent modeling assumptions. After discussing which socioeconomic units are potentially important for ESMs, we compare models of individual decision making that correspond to alternative behavioral theories and that make diverse modeling assumptions about individuals’ preferences, beliefs, decision rules, and foresight. We review approaches to model social interaction, covering game theoretic frameworks, models of social influence, and network models. Finally, we discuss approaches to studying how the behavior of individuals, groups, and organizations can aggregate to complex collective phenomena, discussing agent-based, statistical, and representative-agent modeling and economic macro-dynamics. We illustrate the main ingredients of modeling techniques with examples from land-use dynamics as one of the main drivers of environmental change bridging local to global scales