Interactions of ligand with the protein.

<p>Red represents protein as cartoon; grey represents interacting side chain as cylinder; and green represents drug as ball and stick model.</p

Canonical pathways predicted by Ingenuity Pathway Analysis for significant genes differentially expressed in kidney cancer.

<p>Canonical pathways predicted by Ingenuity Pathway Analysis for significant genes differentially expressed in kidney cancer.</p

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Additional file 3: Table S2. Differentially expressed cancer driver genes [66] in individual tumors compared with three normal brain sample data sets, referenced in Gene Expression Omnibus (GEO) submission GSE77259. Values were generated from previously published data sets [64, 65] using Transcriptome Analysis Console v. 4.0

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Additional file 5: Figure S3. A. Representative immunofluorescence images for consecutive sections for the grade I Jed64_MN meningioma. Sections were double stained for Ki67 (red) with Nestin (green), SOX2 (red) with CD133 (green), Vimentin (green) with FZD9 (red), SSEA4 (green) with SOX2 (red), and SSEA4 (green) with Olig2 (red), and each section was stained with DAPI (blue). Single staining of GFAP (red) or BIIITubulin (red) is also shown. All images were taken at 20x. B. A grid used as a repository of information for categorical staining is shown with a color-coded legend and size dimensions for sub-areas

Binding and interaction values for docking of S100A8 dimer and EGFR kinase domain with inhibitors (midostaurin, enzastaurin and gefitinib).

<p>Binding and interaction values for docking of S100A8 dimer and EGFR kinase domain with inhibitors (midostaurin, enzastaurin and gefitinib).</p

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Additional file 1: Table S1. The clinical profiles for the included patients and their tumors’ histopathological features

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Additional file 4: Figure S2. A bar graph showing averages of counts for Ki67 stained sections collected using manual counting or automated counting in Image J software

Leukocyte Extravasation Signaling: Transcriptomic signatures of kidney cancer showed a significant activation in leukocyte extravasation signaling pathway.

<p>Red represents overexpression and green underexpression.</p

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Additional file 6: Figure S4. A. Representative immunofluorescence images for consecutive sections for the grade III Jed29_MN meningioma. Sections were double stained for Ki67 (red) with Nestin (green), SOX2 (red) with CD133 (green), Vimentin (green) with FZD9 (red), SSEA4 (green) with SOX2 (red), and SSEA4 (green) with Olig2 (red), and each section was stained with DAPI (blue). Single staining of GFAP (red) or BIIITubulin (red) is also shown. All images were taken at 20x. B. A grid used as a repository of information for categorical staining is shown with a color-coded legend and size dimensions for sub-areas

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Additional file 2: Figure S1. H&E images for different morphological variants and atypical features for meningiomas used in this study. A. Images showing WHO classified morphological features for different meningioma variants. Meningothelial (Jed39_MN) with neoplastic growth of syncytial epithelial cells with indistinct cell borders arranged in whorls; fibroblastic (Jed40_MN) showing spindle cells with indistinct cell boundaries running in fascicle; transitional (Jed38_MN) with ratios of meningothelial to fibroblastic patterns 40:60; psammomatous (Jed43_MN) composed of whorled clusters of spindle cells with numerous psammoma bodies; chordoid (Jed79_MN), Cords of epithelioid cells with focal clear to foamy cytoplasm on myxoid stroma.; rhabdoid (Jed29_MN) showing hypercellular sheets with rhabdoid morphology. B. Tumors with atypical features. Images show patternless growth (sheeting) in Jed72_MN, necrosis and small cells with high nuclear to cytoplasm ratio in Jed58_MN, and brain invasion in Jed13_MN. Magnifications are indicated above images