Additional file 1 of An exploration of students’ use of digital resources for self-study in anatomy: a survey study

Supplementary Material

Renal function parameters.

<p>Changes in Creatinine clearance (A), Fractional excretion of sodium (FENA) (B) and diuresis (C) in response to lipopolysaccharide infusion and treatment with either the selective ETA antagonist, TBC 3711 (2 mg·kg ⁻¹, n = 8) or control (n = 8) Data are expressed as mean ± SEM. <b>#</b> indicates a significant difference between TBC 3711 and control in response to lipopolysaccharide. (ANOVA repeated measures including 120, 180, 240 and 300). * indicates a significant change in effect over time (120–300).</p

Renal hemodynamics.

<p>Changes in mean arterial blood pressure (MAP) (A), renal blood flow (RBF) (B), Laser Doppler flowmetry renal cortex (LD Cortex) (C) and Laser Doppler flowmetry renal medulla (LD Medulla) (D) in response to lipopolysaccharide infusion and treatment with either the selective ETA antagonist, TBC 3711 (2 mg·kg⁻¹, n = 8) or control (n = 8). Data are expressed as mean ± SEM. # indicates a significant difference between TBC 3711 and control in response to lipopolysaccharide. (ANOVA repeated measures including 120, 180, 240 and 300). * indicates a significant change in effect over time (120–300).</p

Renal oxygen transport and metabolism.

<p>Changes in lactate/pyruvate ratio cortex (L/P cortex) (A), lactate/pyruvate ratio medulla (L/P medulla) (B), Renal oxygen consumption (VO2renal) (C) and Renal oxygen extraction (O2EXrenal) (D) in response to lipopolysaccharide infusion and treatment with either the selective ETA antagonist, TBC 3711 (2 mg·kg −1, n = 8) or control (n = 8) Data are expressed as mean ± SEM. # indicates a significant difference between TBC 3711 and control in response to lipopolysaccharide. (ANOVA repeated measures including 120, 180, 240 and 300).</p

Systemic and renal parameters.

<p>Data are for TBC 3711 (TBC, n = 8) and Control (n = 8) expressed as mean ± SEM. ANOVA repeated measures including 120, 180, 240 and 300 was performed. The p-value refers to the time-treatment interaction using these time-points. Differences were considered significant at <i>p</i>≤0.05. ET-1 = Endothelin-1, RVC = Renal vascular conductance,.</p