Depressive Cognitions In University Students: An Investigation Of Two Theories Of Depression

The purpose of this study was to examine concurrently the Beck and Seligman cognitive theories of depression. The study involved the testing of task perceptions, and self-referent perceptions more germane to the theories. The relevance of Bandura\u27s self-efficacy construct, to the understanding of depression, was also assessed. Further, issues pertaining to the assessment of depression and to the generalizability of experimental tasks were investigated.;The subjects in the study were undergraduate university women, who qualified for one of three subject groups. On the basis of the Beck Depression Inventory (BDI), a nondepressed (Normal) and depressed group (Severity) were formed. An additional depressed group (Clinical) was derived using both a severity criterion (BDI) and the Research Diagnostic Criteria.;The study involved a 3 (subject group) x 2 (task) factorial design. Half of the subjects from each group were assigned the Alloy and Abramson task, involving the problem of determining amount of control over the outcome. The other subjects received the Wener and Rehm task, in which they were to maximize their success. Regardless of the task condition, all subjects received experimenter-controlled feedback to only 20% of their responses.;The Clinically depressed group differed from the other two groups on most of the dependent measures relevant to Beck\u27s theory, but only on the measure of the central tenant of Seligman\u27s theory. Overall, the results of this study generally supported Beck\u27s cognitive theory but not Seligman\u27s learned helplessness theory of depression. Consideration was also given to the relevance of the concept of self-efficacy and of stress to depression, as well as the importance of subject selection criteria in depression research

Vulnerable consumers : marketing research needs to pay more attention to the brain health of consumers

We propose here that marketing research should increase consideration of the brain health of consumers, and argue that it would help both extend our current knowledge of vulnerable and other marginalised groups, as well as extend generalizability and external validity of marketing research in general. We show that such a focus would help enrich methodology, especially around causal inference, as well as impact on our understanding of a number of key emerging themes in marketing research. We particularly focus on the consumer behaviour around digitalisation, as well as compulsive buying behaviour. Further, we show that increasing consideration of consumer brain health will further efforts towards inclusivity of marketing, and help continue progress towards marketing research as a force for good

P4‐617: Working Memory Maintenance Accuracy In Elderly Adults With Extraordinary Episodic Memory

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152719/1/alzjjalz201908165.pd

White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment

In a previous report showing white matter microstructural hemispheric asymmetries medial to the pallidum in focal dystonias, we showed preliminary evidence that this abnormality was reduced 4 weeks after botulinum toxin (BTX) injections. In the current study we report the completed treatment study in a full-size cohort of CD patients (n = 14). In addition to showing a shift toward normalization of the hemispheric asymmetry, we evaluated clinical relevance of these findings by relating white matter changes to degree of symptom improvement. We also evaluated whether the magnitude of the white matter asymmetry before treatment was related to severity, laterality, duration of dystonia, and/or number of previous BTX injections. Our results confirm the findings of our preliminary report: we observed significant fractional anisotropy (FA) changes medial to the pallidum 4 weeks after BTX in CD participants that were not observed in controls scanned at the same interval. There was a significant relationship between magnitude of hemispheric asymmetry and dystonia symptom improvement, as measured by percent reduction in dystonia scale scores. There was also a trend toward a relationship between magnitude of pre-injection white matter asymmetry and symptom severity, but not symptom laterality, disorder duration, or number of previous BTX injections. Post-hoc analyses suggested the FA changes at least partially reflected changes in pathophysiology, but a dissociation between patient perception of benefit from injections and FA changes suggested the changes did not reflect changes to the primary “driver” of the dystonia. In contrast, there were no changes or group differences in DTI diffusivity measures, suggesting the hemispheric asymmetry in CD does not reflect irreversible white matter tissue loss. These findings support the hypothesis that central nervous system white matter changes are involved in the mechanism by which BTX exerts clinical benefit

Evidence for Altered Basal Ganglia-Brainstem Connections in Cervical Dystonia

Background: There has been increasing interest in the interaction of the basal ganglia with the cerebellum and the brainstem in motor control and movement disorders. In addition, it has been suggested that these subcortical connections with the basal ganglia may help to coordinate a network of regions involved in mediating posture and stabilization. While studies in animal models support a role for this circuitry in the pathophysiology of the movement disorder dystonia, thus far, there is only indirect evidence for this in humans with dystonia. Methodology/Principal Findings: In the current study we investigated probabilistic diffusion tractography in DYT1-negative patients with cervical dystonia and matched healthy control subjects, with the goal of showing that patients exhibit altered microstructure in the connectivity between the pallidum and brainstem. The brainstem regions investigated included nuclei that are known to exhibit strong connections with the cerebellum. We observed large clusters of tractography differences in patients relative to healthy controls, between the pallidum and the brainstem. Tractography was decreased in the left hemisphere and increased in the right hemisphere in patients, suggesting a potential basis for the left/right white matter asymmetry we previously observed in focal dystonia patients. Conclusions/Significance: These findings support the hypothesis that connections between the basal ganglia and brainstem play a role in the pathophysiology of dystonia

Brain structure can mediate or moderate the relationship of behavior to brain function and transcriptome. A preliminary study

Abnormalities in motor-control behavior, which have been with concussion and head acceleration events (HAE), can be quantified using virtual reality (VR) technologies. Motor-control behavior has been consistently mapped to the brain's somatomotor network (SM) using both structural (sMRI) and functional MRI (fMRI). However, no studies habe integrated HAE, motor-control behavior, sMRI and fMRI measures. Here, brain networks important for motor-control were hypothesized to show changes in tractography-based diffusion weighted imaging [difference in fractional anisotropy (dFA)] and resting-state fMRI (rs-fMRI) measures in collegiate American football players across the season, and that these measures would relate to VR-based motor-control. We firther tested if nine inflammation-related miRNAs were associated with behavior-structure-function variables. Using permutation-based mediation and moderation methods, we found that across-season dFA from the SM structural connectome (SM-dFA) mediated the relationship between across-season VR-based Sensory-motor Reactivity (dSR) and rs-fMRI SM fingerprint similarity (p = 0.007 and Teff = 47%). The interaction between dSR and SM-dFA also predicted (pF = 0.036, pbeta3 = 0.058) across-season levels of dmiRNA-30d through permutation-based moderation analysis. These results suggest (1) that motor-control is in a feedback relationship with brain structure and function, (2) behavior-structure-function can be connected to HAE, and (3) behavior-structure might predict molecular biology measures.Comment: 62 pages, 4 figures, 2 table

Redefining neuromarketing as an integrated science of influence

Multiple transformative forces target marketing, many of which derive from new technologies that allow us to sample thinking in real time (i.e., brain imaging), or to look at large aggregations of decisions (i.e., big data). There has been an inclination to refer to the intersection of these technologies with the general topic of marketing as “neuromarketing”. There has not been a serious effort to frame neuromarketing, which is the goal of this paper. Neuromarketing can be compared to neuroeconomics, wherein neuroeconomics is generally focused on how individuals make “choices”, and represent distributions of choices. Neuromarketing, in contrast, focuses on how a distribution of choices can be shifted or “influenced”, which can occur at multiple “scales” of behavior (e.g., individual, group, or market/society). Given influence can affect choice through many cognitive modalities, and not just that of valuation of choice options, a science of influence also implies a need to develop a model of cognitive function integrating attention, memory, and reward/aversion function. The paper concludes with a brief description of three domains of neuromarketing application for studying influence, and their caveats