1 research outputs found
BorylationâReductionâBorylation for the Formation of 1,4-Azaborines
This project has received funding from the Leverhulme Trust (grant Number RPG-2022-032) and the European Research Council (ERC) under the European Unionâs Horizon 2020 research and innovation program (Grant Agreement No. 769599). M.J.I. and E.Z.-C. also thank the EPSRC Programme Grant âBoron: Beyond the Reagentâ (EP/W007517/1) for support.Given the current interest in materials containing 1,4-azaborine units, the development of new routes to these structures is important. Carbonyl directed electrophilic borylation using BBr3 is a facile method for the ortho-borylation of N,N-diaryl-amide derivatives. Subsequent addition of Et3SiH results in carbonyl reduction and then formation of 1,4-azaborines that can be protected in situ using a Grignard reagent. Overall, borylationâreductionâborylation is a one-pot methodology to access 1,4-azaborines from simple precursors.Publisher PDFPeer reviewe