Association of 10 SNPs on 9p22 with abnormal TVU screening results.

<p>Per allele odds ratios obtained with an additive model restricted to the Caucasian population for the association of 9p22 SNPs with abnormal screening results are shown. Cases are women with suspicious screening results; controls are women with normal or non-suspicious screening results. Worst TVU results indicate abnormal TVU results at any screen during the 4-year follow-up. First TVU results indicate abnormal TVU results at the first screen a woman participated in. Incident TVU results are abnormal results among women that were normal or non-suspicious at the first screening. An asterisk indicates p-values lower than 0.005, the significance level after conservative Bonferroni correction.</p

LD-plot of 10 SNPs on 9p22 from individuals included in the analysis.

<p>The LD-plot was generated with Haploview based on r² of the 10 SNPs on 9p22 in 992 Caucasian women with genotyping information and transvaginal ultrasound results available.</p

Risk factors and screening results in the subgroup with SNP data.

<p>TVU = transvaginal ultrasound; Family hx = family history; PMH = Post-menopausal hormone; OC = oral contraceptive; GWAS = genome-wide association study.</p

Distribution of risk factors and diagnostic factors by CIN3 size among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).

a<p>High Risk/Oncogenic HPV type defined as positive for any of the following HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68.</p

LEEPs performed among SUCCEED women in a colposcopy clinic, 2003–2010.

<p>LEEPs performed among SUCCEED women in a colposcopy clinic, 2003–2010.</p

Distribution of age, sexual activity span, and number of CINs among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).

<p>Distribution of age, sexual activity span, and number of CINs among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).</p

Sample of individual data for depicting the distribution of CIN LEEP segments among women in SUCCEED diagnosed as with CIN3 by LEEP.

<p>Sample of individual data for depicting the distribution of CIN LEEP segments among women in SUCCEED diagnosed as with CIN3 by LEEP.</p

Distribution of diagnostic factors among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).

a<p>High Risk/Oncogenic HPV type defined as positive for any of the following HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68.</p

Distribution of CIN LEEP segments among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).

<p>Distribution of CIN LEEP segments among women in SUCCEED diagnosed as CIN3 by LEEP (N = 309).</p

Genetic Risk Scores Based on Biologic Single Nucleotide Polymorphism Subsets and Endometrial Cancer Risk Among Women of European Ancestry.

<p>Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio.</p><p>^a Unconditional logistic regression models adjusted for age at diagnosis and study were used to estimate per risk allele odds ratios and 95% confidence intervals</p><p>^b Unconditional logistic regression models were additionally adjusted for BMI</p><p>Genetic Risk Scores Based on Biologic Single Nucleotide Polymorphism Subsets and Endometrial Cancer Risk Among Women of European Ancestry.</p