16 research outputs found

    Parameters characterizing the concentration of free radicals described by equation 4.

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    <p>Parameters characterizing the concentration of free radicals described by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120858#pone.0120858.e004" target="_blank">equation 4</a>.</p

    Estrogenic and cytotoxic activity of tested compounds in HEK293 cells transfected with wild type ERα receptor or plasmids bearing mutated versions of ERα.

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    <p><b>A</b>.- HEK293 were transfected with wild type ERα receptor or Erα W383A and W383S plasmids and an ER dependent luciferase reporter gene. Results are expressed as mean ± SEM (n = 8). * <i>p</i> < 0.05 was considered statistically significant. <b>B</b>.- HEK293 were transfected mock-transfected or transfected with wild type ERα or Erα W383S plasmids. 48 h after transfection, cells were incubated in the presence of increasing concentrations of compounds 18 for 72 h and cell viability was measured by MTT assay. Results are reported as % viability based on the untreated control cells normalized to 100% viable. Results represent means ± SEM (n = 8). * <i>p</i> <0.05 versus mock-transfected untransfected cells. # p<0.05 versus ERα W383S transfected cells.</p
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