Glutamine Supplementation in Sick Children: Is It Beneficial?

The purpose of this review is to provide a critical appraisal of the literature on Glutamine (Gln) supplementation in various conditions or illnesses that affect children, from neonates to adolescents. First, a general overview of the proposed mechanisms for the beneficial effects of Gln is provided, and subsequently clinical studies are discussed. Despite safety, studies are conflicting, partly due to different effects of enteral and parenteral Gln supplementation. Further insufficient evidence is available on the benefits of Gln supplementation in pediatric patients. This includes premature infants, infants with gastrointestinal disease, children with Crohn's disease, short bowel syndrome, malnutrition/diarrhea, cancer, severe burns/trauma, Duchenne muscular dystrophy, sickle cell anemia, cystic fibrosis, and type 1 diabetes. Moreover, methodological issues have been noted in some studies. Further mechanistic data is needed along with large randomized controlled trials in select populations of sick children, who may eventually benefit from supplemental Gln

Duchenne muscular dystrophy: a model for studying the contribution of muscle to energy and protein metabolism

International audienc

Natural isotopic abundances as markers of compliance in clinical trials

International audienc

Dépistage systématique de l'obésité en remplacement de médecine générale

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Suivi cardio-vasculaire des patients traités dès l'enfance par LDL aphérèses pour une hypercholestérolémie familiale homozygote

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Effets de la corpulence sur la composition en macronutriments du lait maternel

Background: Weight gain from 0 to 1 month old is lower in breast-fed infants of obese mothers compared to lean mothers. Obese women breast milk composition has not been studied yet and may explain the difference in weight gain. The aim of this study was to compare the flow and the macronutrient composition of 1 month breast milk of obese and lean mother's. Subjects and methods: This is a prospective, case control study, supported by a PHRC. Patients were recruited in Poitiers and Châtellerault maternity wards. Fifty obese mothers (BMI >= 30 kg/m2) exclusively breastfeeding ere matched ith fifty lean mothers (18.5 <= BMI < 25 kg/m2) according to their age, parity, geographical origin and educational level. A breast-milk sample was collected at 1 month postnatal for analysis by mid-red spectroscopy to determine macronutrient concentration. Results: Milk flow during suckling was lower in obese women (6.7 +- 3.7 vs 5.1 +- 3.5 ml.min-1, p<0,05). No difference was found in the carbohydrates, proteins, lipids and energy composition. Only the total solids were higher in breast milk of obese women (12.4 +- 1.6 vs 11.7 +- 1.3 g%, p<0,05). Conclusion: The lower milk flow in obese mothers might explain the lower weight gain in breast-fed infants of obese women. We could not confirm a greater energy and lipid content in obese omen's breast milk, due to a lack of statistical power. Qualitative analysis of milk lipids is in progress.POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Les effets de la corpulence maternelle sur la concentration du lait en leptine et sur le gain pondéral des nourissons à 1 mois

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Flore fécale de la mère allaitante et de son nouveau-né à un mois de vie

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF