1 research outputs found
Umpolung Strategy for Synthesis of β‑Ketonitriles through Hypervalent Iodine-Promoted Cyanation of Silyl Enol Ethers
An
efficient method to synthesize β-ketonitriles from silyl
enol ethers by an umploung hypervalent iodineÂ(III)–CN species
generated <i>in situ</i> from PhIO/BF<sub>3</sub>·Et<sub>2</sub>O/TMSCN has been developed for the first time. This method
can be applied to structurally diverse aromatic and aliphatic substrates
and further extended to preparation of bioactive compounds like 5-aminopyrazole
and 5-aminoisoxazole