3,027 research outputs found
The Influence of in-medium NN cross-sections, symmetry potential and impact parameter on the isospin observables
We explore the influence of in-medium nucleon-nucleon cross section, symmetry
potential and impact parameter on isospin sensitive observables in
intermediate-energy heavy-ion collisions with the ImQMD05 code, a modified
version of Quantum Molecular Dynamics model. At incident velocities above the
Fermi velocity, we find that the density dependence of symmetry potential plays
a more important role on the double neutron to proton ratio and the
isospin transport ratio than the in-medium nucleon-nucleon cross
sections, provided that the latter are constrained to a fixed total NN
collision rate. We also explore both and as a function of the
impact parameter. Since the copious production of intermediate mass fragments
is a distinguishing feature of intermediate-energy heavy-ion collisions, we
examine the isospin transport ratios constructed from different groups of
fragments. We find that the values of the isospin transport ratios for
projectile rapidity fragments with are greater than those constructed
from the entire projectile rapidity source. We believe experimental
investigations of this phenomenon can be performed. These may provide
significant tests of fragmentation time scales predicted by ImQMD calculations.Comment: 24 pages, 9 figures, to be published in Phys. Rev.
Diffeomorphic approximation of Sobolev homeomorphisms
Every homeomorphism h : X -> Y between planar open sets that belongs to the
Sobolev class W^{1,p}(X,Y), 1<p<\infty, can be approximated in the Sobolev norm
by diffeomorphisms.Comment: 21 pages, 5 figure
LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment options. In particular, molecularly targeted therapies for hepatocellular carcinoma targeting cellular receptors and kinases have yielded disappointing clinical results, providing an urgency for targeting distinct mechanisms. LSF small molecule inhibitors, Factor Quinolinone Inhibitors (FQIs), have exhibited robust anti-tumor activity in multiple pre-clinical models of hepatocellular carcinoma, with no observable toxicity. To understand how the inhibitors impact cancer cell proliferation, we characterized the cellular phenotypes that result from loss of LSF activity. Phenotypically, inhibition of LSF activity induced a mitotic delay with condensed, but unaligned, chromosomes. This mitotic disruption resulted in improper cellular division leading to multiple outcomes: multi-nucleation, apoptosis, and cellular senescence. The cellular phenotypes observed upon FQI1 treatment were due specifically to the loss of LSF activity, as siRNA specifically targeting LSF produced nearly identical phenotypes. Taken together, these findings confirm that LSF is a promising therapeutic target for cancer treatment.First author draf
Cholecystokinin B-type Receptors Mediate a G-Protein-Dependent Depolarizing Action of Sulphated Cholecystokinin Ocatapeptide (CCK-8s) on Rodent Neonatal Spinal Ventral Horn Neurons
Reports of cholecystokinin (CCK) binding and expression of CCK receptors in neonatal rodent spinal cord suggest that CCK may influence neuronal excitability. In patch-clamp recordings from 19/21 ventral horn motoneurons in neonatal (PN 5–12 days) rat spinal cord slices, we noted a slowly rising and prolonged membrane depolarization induced by bath-applied sulfated CCK octapeptide (CCK-8s; 1 μM), blockable by the CCKB receptor antagonist L-365,260 (1 μM). Responses to nonsulfated CCK-8 or CCK-4 were significantly weaker. Under voltage clamp (VH −65 mV), 22/24 motoneurons displayed a CCK-8s-induced tetrodotoxin-resistant inward current [peak: −136 ± 28 pA] with a similar time course, mediated via reduction in a potassium conductance. In 29/31 unidentified neurons, CCK-8s induced a significantly smaller inward current (peak: −42.8 ± 5.6 pA), and I-V plots revealed either membrane conductance decrease with net inward current reversal at 101.3 ± 4.4 mV (n = 16), membrane conductance increase with net current reversing at 36.1 ± 3.8 mV (n = 4), or parallel shift (n = 9). Intracellular GTP-γ-S significantly prolonged the effect of CCK-8s (n = 6), whereas GDP-β-S significantly reduced the CCK-8s response (n = 6). Peak inward currents were significantly reduced after 5-min perfusion with N-ethylmaleimide. In isolated neonatal mouse spinal cord preparations, CCK-8s (30–300 nM) increased the amplitude and discharge of spontaneous depolarizations recorded from lumbosacral ventral roots. These observations imply functional postsynaptic G-protein-coupled CCKB receptors are prevalent in neonatal rodent spinal cord
Deformations of the hemisphere that increase scalar curvature
Consider a compact Riemannian manifold M of dimension n whose boundary
\partial M is totally geodesic and is isometric to the standard sphere S^{n-1}.
A natural conjecture of Min-Oo asserts that if the scalar curvature of M is at
least n(n-1), then M is isometric to the hemisphere S_+^n equipped with its
standard metric. This conjecture is inspired by the positive mass theorem in
general relativity, and has been verified in many special cases. In this paper,
we construct counterexamples to Min-Oo's conjecture in dimension n \geq 3.Comment: Revised version, to appear in Invent. Mat
Four-Dimensional Effective Supergravity and Soft Terms in M-Theory
We provide a simple macroscopic analysis of the four-dimensional effective
supergravity of the Ho\v{r}ava-Witten M-theory which is expanded in powers of
and where ,
and denote the eleven-dimensional gravitational coupling, the
Calabi-Yau volume and the eleventh length respectively. Possible higher order
terms in the K\"ahler potential are identified and matched with the heterotic
string corrections. In the context of this M-theory expansion, we analyze the
soft supersymmetry-breaking terms under the assumption that supersymmetry is
spontaneously broken by the auxiliary components of the bulk moduli
superfields. It is examined how the pattern of soft terms changes when one
moves from the weakly coupled heterotic string limit to the M-theory limit.Comment: Latex, 23 pages, 3 figures. References are added and the discussion
of the M-theory expansion parameters is enlarge
Dynamic nuclear polarization at the edge of a two-dimensional electron gas
We have used gated GaAs/AlGaAs heterostructures to explore nonlinear
transport between spin-resolved Landau level (LL) edge states over a submicron
region of two-dimensional electron gas (2DEG). The current I flowing from one
edge state to the other as a function of the voltage V between them shows
diode-like behavior---a rapid increase in I above a well-defined threshold V_t
under forward bias, and a slower increase in I under reverse bias. In these
measurements, a pronounced influence of a current-induced nuclear spin
polarization on the spin splitting is observed, and supported by a series of
NMR experiments. We conclude that the hyperfine interaction plays an important
role in determining the electronic properties at the edge of a 2DEG.Comment: 8 pages RevTeX, 7 figures (GIF); submitted to Phys. Rev.
Satin associated lower cancer risk and related mortaity in patients with heart failure
Aims Patients with heart failure (HF) have an increased risk of incident cancer. Data relating to the association of statin use with cancer risk and cancer-related mortality among patients with HF are sparse. Methods and results Using a previously validated territory-wide clinical information registry, statin use was ascertained among all eligible patients with HF (n = 87 102) from 2003 to 2015. Inverse probability of treatment weighting was used to balance baseline covariates between statin nonusers (n = 50 926) with statin users (n = 36 176). Competing risk regression with Cox proportional-hazard models was performed to estimate the risk of cancer and cancer-related mortality associated with statin use. Of all eligible subjects, the mean age was 76.5 +/- 12.8 years, and 47.8% was male. Over a median follow-up of 4.1 years (interquartile range: 1.6-6.8), 11 052 (12.7%) were diagnosed with cancer. Statin use (vs. none) was associated with a 16% lower risk of cancer incidence [multivariable adjusted subdistribution hazard ratio (SHR) = 0.84; 95% confidence interval (CI), 0.80-0.89]. This inverse association with risk of cancer was duration dependent; as compared with short-term statin use (3 months to = 6 years of use. Ten-year cancer-related mortality was 3.8% among statin users and 5.2% among nonusers (absolute risk difference, -1.4 percentage points [95% CI, -1.6% to -1.2%]; adjusted SHR= 0.74; 95% CI, 0.67-0.81). Conclusion Our study suggests that statin use is associated with a significantly lower risk of incident cancer and cancer-related mortality in HF, an association that appears to be duration dependent. [GRAPHICS]
Dynamical Properties and Plasmon Dispersion of a Weakly Degenerate Correlated One-Component Plasma
Classical Molecular Dynamics (MD) simulations for a one-component plasma
(OCP) are presented. Quantum effects are included in the form of the Kelbg
potential. Results for the dynamical structure factor are compared with the
Vlasov and RPA (random phase approximation) theories. The influence of the
coupling parameter , degeneracy parameter and the form
of the pair interaction on the optical plasmon dispersion is investigated. An
improved analytical approximation for the dispersion of Langmuir waves is
presented.Comment: 23 pages, includes 7 ps/eps-figures and 2 table
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